Jacobsen Group Paper of the Year Master List - 2018


Nature


1. Synthesis, structure and reaction chemistry of a nucleophilic aluminyl anion

[no graphical abstract]

Jamie Hicks; Petra Vasko; Jose M. Goicoechea; Simon Aldridge. Nature. 2018, 557, 92. DOI: 10.1038/s41586-018-0037-y


2. Enantioselective remote meta -C–H arylation and alkylation via a chiral transient mediator

[no graphical abstract]

Hang Shi; Alastair N. Herron; Ying Shao; Qian Shao; Jin-Quan Yu. Nature. 2018, 558, 581. DOI: 10.1038/s41586-018-0220-1


3. Controlling an organic synthesis robot with machine learning to search for new reactivity

[no graphical abstract]

Jarosław M. Granda; Liva Donina; Vincenza Dragone; De-Liang Long; Leroy Cronin. Nature. 2018, 559, 377. DOI: 10.1038/s41586-018-0307-8


4. Decarboxylative sp 3 C–N coupling via dual copper and photoredox catalysis

[no graphical abstract]

Yufan Liang; Xiaheng Zhang; David W. C. MacMillan. Nature. 2018, 559, 83. DOI: 10.1038/s41586-018-0234-8


5. Building C( sp 3 )-rich complexity by combining cycloaddition and C–C cross-coupling reactions

[no graphical abstract]

Tie–Gen Chen; Lisa M. Barton; Yutong Lin; Jet Tsien; David Kossler; Iñaki Bastida; Shota Asai; Cheng Bi; Jason S. Chen; Mingde Shan; Hui Fang; Francis G. Fang; Hyeong-wook Choi; Lynn Hawkins; Tian Qin; Phil S. Baran. Nature. 2018, 560, 350. DOI: 10.1038/s41586-018-0391-9


6. Cooperative asymmetric reactions combining photocatalysis and enzymatic catalysis

[no graphical abstract]

Zachary C. Litman; Yajie Wang; Huimin Zhao; John F. Hartwig. Nature. 2018, 560, 355. DOI: 10.1038/s41586-018-0413-7


7. Velocity-resolved kinetics of site-specific carbon monoxide oxidation on platinum surfaces

[no graphical abstract]

Jannis Neugebohren; Dmitriy Borodin; Hinrich W. Hahn; Jan Altschäffel; Alexander Kandratsenka; Daniel J. Auerbach; Charles T. Campbell; Dirk Schwarzer; Dan J. Harding; Alec M. Wodtke; Theofanis N. Kitsopoulos. Nature. 2018, 558, 280. DOI: 10.1038/s41586-018-0188-x


8. Palladium-catalysed electrophilic aromatic C–H fluorination

[no graphical abstract]

Kumiko Yamamoto; Jiakun Li; Jeffrey A. O. Garber; Julian D. Rolfes; Gregory B. Boursalian; Jannik C. Borghs; Christophe Genicot; Jérôme Jacq; Maurice van Gastel; Frank Neese; Tobias Ritter. Nature. 2018, 554, 511. DOI: 10.1038/nature25749


9. Generating carbyne equivalents with photoredox catalysis

[no graphical abstract]

Zhaofeng Wang; Ana G. Herraiz; Ana M. del Hoyo; Marcos G. Suero. Nature. 2018, 554, 86. DOI: 10.1038/nature25185


10. Quaternary stereocentres via an enantioconvergent catalytic S N 1 reaction

[no graphical abstract]

Alison E. Wendlandt; Prithvi Vangal; Eric N. Jacobsen. Nature. 2018, 556, 447. DOI: 10.1038/s41586-018-0042-1


11. Planning chemical syntheses with deep neural networks and symbolic AI

[no graphical abstract]

Marwin H. S. Segler; Mike Preuss; Mark P. Waller. Nature. 2018, 555, 604. DOI: 10.1038/nature25978


12. Multicomponent synthesis of tertiary alkylamines by photocatalytic olefin-hydroaminoalkylation

[no graphical abstract]

Aaron Trowbridge; Dominik Reich; Matthew J. Gaunt. Nature. 2018, 561, 522. DOI: 10.1038/s41586-018-0537-9


13. Asymmetric α-arylation of amino acids

[no graphical abstract]

Daniel J. Leonard; John W. Ward; Jonathan Clayden. Nature. 2018, 562, 105. DOI: 10.1038/s41586-018-0553-9


14. A protein functionalization platform based on selective reactions at methionine residues

[no graphical abstract]

Michael T. Taylor; Jennifer E. Nelson; Marcos G. Suero; Matthew J. Gaunt. Nature. 2018, 562, 563. DOI: 10.1038/s41586-018-0608-y


15. Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis

[no graphical abstract]

Matthew K. Bilyard; Henry J. Bailey; Lluís Raich; Maria A. Gafitescu; Takuya Machida; Javier Iglésias-Fernández; Seung Seo Lee; Christopher D. Spicer; Carme Rovira; Wyatt W. Yue; Benjamin G. Davis. Nature. 2018, 563, 235. DOI: 10.1038/s41586-018-0644-7


16. Catalytic enantioconvergent coupling of secondary and tertiary electrophiles with olefins

[no graphical abstract]

Zhaobin Wang; Haolin Yin; Gregory C. Fu. Nature. 2018, 563, 379. DOI: 10.1038/s41586-018-0669-y


17. Deconstructive diversification of cyclic amines

[no graphical abstract]

Jose B. Roque; Yusuke Kuroda; Lucas T. Göttemann; Richmond Sarpong. Nature. 2018, 564, 244. DOI: 10.1038/s41586-018-0700-3


18. Catalytic deracemization of chiral allenes by sensitized excitation with visible light

[no graphical abstract]

Alena Hölzl-Hobmeier; Andreas Bauer; Alexandre Vieira Silva; Stefan M. Huber; Christoph Bannwarth; Thorsten Bach. Nature. 2018, 564, 240. DOI: 10.1038/s41586-018-0755-1


19. Desymmetrization of cyclohexanes by site- and stereoselective C–H functionalization

[no graphical abstract]

Jiantao Fu; Zhi Ren; John Bacsa; Djamaladdin G. Musaev; Huw M. L. Davies. Nature. 2018, 564, 395. DOI: 10.1038/s41586-018-0799-2


Science


20. Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis

[no graphical abstract]

Gabriele Pupo; Francesco Ibba; David M. H. Ascough; Anna Chiara Vicini; Paolo Ricci; Kirsten E. Christensen; Lukas Pfeifer; John Richard Morphy; John M. Brown; Robert S. Paton; Véronique Gouverneur. Science. 2018, 360, 1–2. DOI: 10.1126/science.aar7941


21. CO2 electroreduction to ethylene via hydroxide-mediated copper catalysis at an abrupt interface

[no graphical abstract]

Cao-Thang Dinh; Thomas Burdyny; Md Golam Kibria; Ali Seifitokaldani; Christine M. Gabardo; F. Pelayo García de Arquer; Amirreza Kiani; Jonathan P. Edwards; Phil De Luna; Oleksandr S. Bushuyev; Chengqin Zou; Rafael Quintero-Bermudez; Yuanjie Pang; David Sinton; Edward H. Sargent. Science. 2018, 360, 1–2. DOI: 10.1126/science.aas9100


22. Cobalt-catalyzed asymmetric hydrogenation of enamides enabled by single-electron reduction

[no graphical abstract]

Max R. Friedfeld; Hongyu Zhong; Rebecca T. Ruck; Michael Shevlin; Paul J. Chirik. Science. 2018, 360, 1–2. DOI: 10.1126/science.aar6117


23. A radical approach to the copper oxidative addition problem: Trifluoromethylation of bromoarenes

[no graphical abstract]

Chip Le; Tiffany Q. Chen; Tao Liang; Patricia Zhang; David W. C. MacMillan. Science. 2018, 360, 1–2. DOI: 10.1126/science.aat4133


24. Separation of enantiomers by their enantiospecific interaction with achiral magnetic substrates

[no graphical abstract]

Koyel Banerjee-Ghosh; Oren Ben Dor; Francesco Tassinari; Eyal Capua; Shira Yochelis; Amir Capua; See-Hun Yang; Stuart S. P. Parkin; Soumyajit Sarkar; Leeor Kronik; Lech Tomasz Baczewski; Ron Naaman; Yossi Paltiel. Science. 2018, 360, 1–2. DOI: 10.1126/science.aar4265


25. Carbonyl catalysis enables a biomimetic asymmetric Mannich reaction

[no graphical abstract]

Jianfeng Chen; Xing Gong; Jianyu Li; Yingkun Li; Jiguo Ma; Chengkang Hou; Guoqing Zhao; Weicheng Yuan; Baoguo Zhao. Science. 2018, 360, 1–2. DOI: 10.1126/science.aat4210


26. Tandem catalysis for asymmetric coupling of ethylene and enynes to functionalized cyclobutanes

[no graphical abstract]

Vinayak Vishnu Pagar; T. V. RajanBabu. Science. 2018, 361, 1–2. DOI: 10.1126/science.aat6205


27. Deconstructive fluorination of cyclic amines by carbon-carbon cleavage

[no graphical abstract]

Jose B. Roque; Yusuke Kuroda; Lucas T. Göttemann; Richmond Sarpong. Science. 2018, 361, 1–2. DOI: 10.1126/science.aat6365


28. Teaching an old carbocation new tricks: Intermolecular C–H insertion reactions of vinyl cations

[no graphical abstract]

Stasik Popov; Brian Shao; Alex L. Bagdasarian; Tyler R. Benton; Luyi Zou; Zhongyue Yang; K. N. Houk; Hosea M. Nelson. Science. 2018, 361, 1–2. DOI: 10.1126/science.aat5440


29. Stereodivergent synthesis of 1,4-dicarbonyls by traceless charge–accelerated sulfonium rearrangement

[no graphical abstract]

Dainis Kaldre; Immo Klose; Nuno Maulide. Science. 2018, 361, 1–2. DOI: 10.1126/science.aat5883


30. Selective functionalization of methane, ethane, and higher alkanes by cerium photocatalysis

[no graphical abstract]

Anhua Hu; Jing-Jing Guo; Hui Pan; Zhiwei Zuo. Science. 2018, 361, 1–2. DOI: 10.1126/science.aat9750


31. Observation of alkaline earth complexes M(CO)8 (M = Ca, Sr, or Ba) that mimic transition metals

[no graphical abstract]

Xuan Wu; Lili Zhao; Jiaye Jin; Sudip Pan; Wei Li; Xiaoyang Jin; Guanjun Wang; Mingfei Zhou; Gernot Frenking. Science. 2018, 361, 1–2. DOI: 10.1126/science.aau0839


32. Natural noncanonical protein splicing yields products with diverse β-amino acid residues

[no graphical abstract]

Brandon I. Morinaka; Edgars Lakis; Marjan Verest; Maximilian J. Helf; Thibault Scalvenzi; Anna L. Vagstad; James Sims; Shinichi Sunagawa; Muriel Gugger; Jörn Piel. Science. 2018, 359, 1–2. DOI: 10.1126/science.aao0157


33. Nitrogen fixation and reduction at boron

[no graphical abstract]

Marc-André Légaré; Guillaume Bélanger-Chabot; Rian D. Dewhurst; Eileen Welz; Ivo Krummenacher; Bernd Engels; Holger Braunschweig. Science. 2018, 359, 1–2. DOI: 10.1126/science.aaq1684


34. Activation of olefins via asymmetric Brønsted acid catalysis

[no graphical abstract]

Nobuya Tsuji; Jennifer L. Kennemur; Thomas Buyck; Sunggi Lee; Sébastien Prévost; Philip S. J. Kaib; Dmytro Bykov; Christophe Farès; Benjamin List. Science. 2018, 359, 1–2. DOI: 10.1126/science.aaq0445


35. Selective formation of γ-lactams via C–H amidation enabled by tailored iridium catalysts

[no graphical abstract]

Seung Youn Hong; Yoonsu Park; Yeongyu Hwang; Yeong Bum Kim; Mu-Hyun Baik; Sukbok Chang. Science. 2018, 359, 1–2. DOI: 10.1126/science.aap7503


36. Asymmetric phosphoric acid–catalyzed four-component Ugi reaction

[no graphical abstract]

Jian Zhang; Peiyuan Yu; Shao-Yu Li; He Sun; Shao-Hua Xiang; Jun (Joelle) Wang; Kendall N. Houk; Bin Tan. Science. 2018, 361, 1–2. DOI: 10.1126/science.aas8707


37. Reconfigurable system for automated optimization of diverse chemical reactions

[no graphical abstract]

Anne-Catherine Bédard; Andrea Adamo; Kosi C. Aroh; M. Grace Russell; Aaron A. Bedermann; Jeremy Torosian; Brian Yue; Klavs F. Jensen; Timothy F. Jamison. Science. 2018, 361, 1–2. DOI: 10.1126/science.aat0650


38. Unlocking P(V): Reagents for chiral phosphorothioate synthesis

[no graphical abstract]

Kyle W. Knouse; Justine N. deGruyter; Michael A. Schmidt; Bin Zheng; Julien C. Vantourout; Cian Kingston; Stephen E. Mercer; Ivar M. Mcdonald; Richard E. Olson; Ye Zhu; Chao Hang; Jason Zhu; Changxia Yuan; Qinggang Wang; Peter Park; Martin D. Eastgate; Phil S. Baran. Science. 2018, 361, 1–2. DOI: 10.1126/science.aau3369


39. Interrupted carbonyl-olefin metathesis via oxygen atom transfer

[no graphical abstract]

Jacob R. Ludwig; Rebecca B. Watson; Daniel J. Nasrallah; Joseph B. Gianino; Paul M. Zimmerman; Ren A. Wiscons; Corinna S. Schindler. Science. 2018, 361, 1–2. DOI: 10.1126/science.aar8238


40. Arylsulfonylacetamides as bifunctional reagents for alkene aminoarylation

[no graphical abstract]

Timothy M. Monos; Rory C. McAtee; Corey R. J. Stephenson. Science. 2018, 361, 1–2. DOI: 10.1126/science.aat2117


41. Confined acids catalyze asymmetric single aldolizations of acetaldehyde enolates

[no graphical abstract]

Lucas Schreyer; Philip S. J. Kaib; Vijay N. Wakchaure; Carla Obradors; Roberta Properzi; Sunggi Lee; Benjamin List. Science. 2018, 362, 1–2. DOI: 10.1126/science.aau0817


42. Ketyl radical reactivity via atom transfer catalysis

[no graphical abstract]

Lu Wang; Jeremy M. Lear; Sean M. Rafferty; Stacy C. Fosu; David A. Nagib. Science. 2018, 362, 1–2. DOI: 10.1126/science.aau1777


43. Chiral Lewis acids integrated with single-walled carbon nanotubes for asymmetric catalysis in water

[no graphical abstract]

Taku Kitanosono; Pengyu Xu; Shū Kobayashi. Science. 2018, 362, 1–2. DOI: 10.1126/science.aap7883


44. Efficient access to unprotected primary amines by iron-catalyzed aminochlorination of alkenes

[no graphical abstract]

Luca Legnani; Gabriele Prina-Cerai; Tristan Delcaillau; Suzanne Willems; Bill Morandi. Science. 2018, 362, 1–2. DOI: 10.1126/science.aat3863


45. Catalytic palladium-oxyallyl cycloaddition

[no graphical abstract]

Barry M. Trost; Zhongxing Huang; Ganesh M. Murhade. Science. 2018, 362, 1–2. DOI: 10.1126/science.aau4821


46. Enantiodivergent Pd-catalyzed C–C bond formation enabled through ligand parameterization

[no graphical abstract]

Shibin Zhao; Tobias Gensch; Benjamin Murray; Zachary L. Niemeyer; Matthew S. Sigman; Mark R. Biscoe. Science. 2018, 362, 1–2. DOI: 10.1126/science.aat2299


47. Heterobiaryl synthesis by contractive C–C coupling via P(V) intermediates

[no graphical abstract]

Michael C. Hilton; Xuan Zhang; Benjamin T. Boyle; Juan V. Alegre-Requena; Robert S. Paton; Andrew McNally. Science. 2018, 362, 1–2. DOI: 10.1126/science.aas8961


Nat. Chem.


48. Palladium-catalysed anti-Markovnikov selective oxidative amination

Daniel G. Kohler; Samuel N. Gockel; Jennifer L. Kennemur; Peter J. Waller; Kami L. Hull. Nat. Chem. 2018, 10, 333. DOI: 10.1038/nchem.2904


49. The domino hexadehydro-Diels–Alder reaction transforms polyynes to benzynes to naphthynes to anthracynes to tetracynes (and beyond?)

Xiao Xiao; Thomas R. Hoye. Nat. Chem. 2018, 10, 838. DOI: 10.1038/s41557-018-0075-y


50. Complementary site-selectivity in arene functionalization enabled by overcoming the ortho constraint in palladium/norbornene catalysis

Jianchun Wang; Renhe Li; Zhe Dong; Peng Liu; Guangbin Dong. Nat. Chem. 2018, 10, 866. DOI: 10.1038/s41557-018-0074-z


51. Approaching sub-ppm-level asymmetric organocatalysis of a highly challenging and scalable carbon–carbon bond forming reaction

Han Yong Bae; Denis Höfler; Philip S. J. Kaib; Pinar Kasaplar; Chandra Kanta De; Arno Döhring; Sunggi Lee; Karl Kaupmees; Ivo Leito; Benjamin List. Nat. Chem. 2018, 10, 888. DOI: 10.1038/s41557-018-0065-0


52. Accelerating proton-coupled electron transfer of metal hydrides in catalyst model reactions

Tianfei Liu; Meiyuan Guo; Andreas Orthaber; Reiner Lomoth; Marcus Lundberg; Sascha Ott; Leif Hammarström. Nat. Chem. 2018, 10, 881. DOI: 10.1038/s41557-018-0076-x


53. Catalytic promiscuity enabled by photoredox catalysis in nicotinamide-dependent oxidoreductases

Kyle F. Biegasiewicz; Simon J. Cooper; Megan A. Emmanuel; David C. Miller; Todd K. Hyster. Nat. Chem. 2018, 10, 770. DOI: 10.1038/s41557-018-0059-y


54. Controlling Pd( iv ) reductive elimination pathways enables Pd( ii )-catalysed enantioselective C( sp 3 )−H fluorination

Hojoon Park; Pritha Verma; Kai Hong; Jin-Quan Yu. Nat. Chem. 2018, 10, 755. DOI: 10.1038/s41557-018-0048-1


55. Manganese-catalysed benzylic C( sp 3 )–H amination for late-stage functionalization

Joseph R. Clark; Kaibo Feng; Anasheh Sookezian; M. Christina White. Nat. Chem. 2018, 10, 583. DOI: 10.1038/s41557-018-0020-0


56. Rapid phenolic O -glycosylation of small molecules and complex unprotected peptides in aqueous solvent

Tyler J. Wadzinski; Angela Steinauer; Liana Hie; Guillaume Pelletier; Alanna Schepartz; Scott J. Miller. Nat. Chem. 2018, 10, 644. DOI: 10.1038/s41557-018-0041-8


57. Cyclometallated ruthenium catalyst enables late-stage directed arylation of pharmaceuticals

Marco Simonetti; Diego M. Cannas; Xavier Just-Baringo; Iñigo J. Vitorica-Yrezabal; Igor Larrosa. Nat. Chem. 2018, 10, 724. DOI: 10.1038/s41557-018-0062-3


58. Cyclometallated ruthenium catalyst enables late-stage directed arylation of pharmaceuticals

Marco Simonetti; Diego M. Cannas; Xavier Just-Baringo; Iñigo J. Vitorica-Yrezabal; Igor Larrosa. Nat. Chem. 2018, 10, 724. DOI: 10.1038/s41557-018-0062-3


59. A general strategy for synthesis of cyclophane-braced peptide macrocycles via palladium-catalysed intramolecular sp 3 C−H arylation

Xuekai Zhang; Gang Lu; Meng Sun; Madhu Mahankali; Yanfei Ma; Mingming Zhang; Wangde Hua; Yuting Hu; Qingbing Wang; Jinghuo Chen; Gang He; Xiangbing Qi; Weijun Shen; Peng Liu; Gong Chen. Nat. Chem. 2018, 10, 540. DOI: 10.1038/s41557-018-0006-y


60. Biocatalytic site- and enantioselective oxidative dearomatization of phenols

Summer A. Baker Dockrey; April L. Lukowski; Marc R. Becker; Alison R. H. Narayan. Nat. Chem. 2017, 10, 119. DOI: 10.1038/nchem.2879


61. Acceleration of a ground-state reaction by selective femtosecond-infrared-laser-pulse excitation

Till Stensitzki; Yang Yang; Valeri Kozich; Ashour A. Ahmed; Florian Kössl; Oliver Kühn; Karsten Heyne. Nat. Chem. 2018, 10, 126. DOI: 10.1038/nchem.2909


62. Direct α-C–H bond functionalization of unprotected cyclic amines

Weijie Chen; Longle Ma; Anirudra Paul; Daniel Seidel. Nat. Chem. 2017, 10, 165. DOI: 10.1038/nchem.2871


63. A general approach to intermolecular carbonylation of arene C–H bonds to ketones through catalytic aroyl triflate formation

R. Garrison Kinney; Jevgenijs Tjutrins; Gerardo M. Torres; Nina Jiabao Liu; Omkar Kulkarni; Bruce A. Arndtsen. Nat. Chem. 2017, 10, 193. DOI: 10.1038/nchem.2903


64. Oxidase catalysis via aerobically generated hypervalent iodine intermediates

Asim Maity; Sung-Min Hyun; David C. Powers. Nat. Chem. 2017, 10, 200. DOI: 10.1038/nchem.2873


65. Iridium-catalysed arylation of C–H bonds enabled by oxidatively induced reductive elimination

Kwangmin Shin; Yoonsu Park; Mu-Hyun Baik; Sukbok Chang. Nat. Chem. 2017, 10, 218. DOI: 10.1038/nchem.2900


66. A general strategy for synthesis of cyclophane-braced peptide macrocycles via palladium-catalysed intramolecular sp 3 C−H arylation

Xuekai Zhang; Gang Lu; Meng Sun; Madhu Mahankali; Yanfei Ma; Mingming Zhang; Wangde Hua; Yuting Hu; Qingbing Wang; Jinghuo Chen; Gang He; Xiangbing Qi; Weijun Shen; Peng Liu; Gong Chen. Nat. Chem. 2018, 10, 540. DOI: 10.1038/s41557-018-0006-y


67. Manganese-catalysed benzylic C( sp 3 )–H amination for late-stage functionalization

Joseph R. Clark; Kaibo Feng; Anasheh Sookezian; M. Christina White. Nat. Chem. 2018, 10, 583. DOI: 10.1038/s41557-018-0020-0


68. Ring-through-ring molecular shuttling in a saturated [3]rotaxane

Kelong Zhu; Giorgio Baggi; Stephen J. Loeb. Nat. Chem. 2018, 10, 625. DOI: 10.1038/s41557-018-0040-9


69. Design of catalysts for site-selective and enantioselective functionalization of non-activated primary C–H bonds

Kuangbiao Liao; Yun-Fang Yang; Yingzi Li; Jacob N. Sanders; K. N. Houk; Djamaladdin G. Musaev; Huw M. L. Davies. Nat. Chem. 2018, 10, 1048. DOI: 10.1038/s41557-018-0087-7


70. Direct α-alkylation of primary aliphatic amines enabled by CO 2 and electrostatics

Juntao Ye; Indrek Kalvet; Franziska Schoenebeck; Tomislav Rovis. Nat. Chem. 2018, 10, 1037. DOI: 10.1038/s41557-018-0085-9


71. Diels–Alder cycloadditions of strained azacyclic allenes

Joyann S. Barber; Michael M. Yamano; Melissa Ramirez; Evan R. Darzi; Rachel R. Knapp; Fang Liu; K. N. Houk; Neil K. Garg. Nat. Chem. 2018, 10, 953. DOI: 10.1038/s41557-018-0080-1


72. Amine hemilability enables boron to mechanistically resemble either hydride or proton

C. Frank Lee; Diego B. Diaz; Aleksandra Holownia; Sherif J. Kaldas; Sean K. Liew; Graham E. Garrett; Travis Dudding; Andrei K. Yudin. Nat. Chem. 2018, 10, 1062. DOI: 10.1038/s41557-018-0097-5


73. Hydrogenation catalyst generates cyclic peptide stereocentres in sequence

Diane N. Le; Eric Hansen; Hasan A. Khan; Byoungmoo Kim; Olaf Wiest; Vy M. Dong. Nat. Chem. 2018, 10, 968. DOI: 10.1038/s41557-018-0089-5


74. Light-driven molecular trap enables bidirectional manipulation of dynamic covalent systems

Michael Kathan; Fabian Eisenreich; Christoph Jurissek; Andre Dallmann; Johannes Gurke; Stefan Hecht. Nat. Chem. 2018, 10, 1031. DOI: 10.1038/s41557-018-0106-8


75. Metathesis-active ligands enable a catalytic functional group metathesis between aroyl chlorides and aryl iodides

Yong Ho Lee; Bill Morandi. Nat. Chem. 2018, 10, 1016. DOI: 10.1038/s41557-018-0078-8


76. Isolation, synthesis and bioactivity studies of phomactin terpenoids

Yusuke Kuroda; Karen J. Nicacio; Ildefonso Alves da Silva-Jr; Paul R. Leger; Stanley Chang; Juliana R. Gubiani; Victor M. Deflon; Nozomu Nagashima; Alexander Rode; Katherine Blackford; Antonio G. Ferreira; Lara D. Sette; David E. Williams; Raymond J. Andersen; Sonia Jancar; Roberto G. S. Berlinck; Richmond Sarpong. Nat. Chem. 2018, 10, 938. DOI: 10.1038/s41557-018-0084-x


77. Catalytic dehydrogenative decarboxyolefination of carboxylic acids

Xiang Sun; Junting Chen; Tobias Ritter. Nat. Chem. 2018, 10, 1229. DOI: 10.1038/s41557-018-0142-4


78. Efficient and stereodivergent synthesis of unsaturated acyclic fragments bearing contiguous stereogenic elements

Jeffrey Bruffaerts; David Pierrot; Ilan Marek. Nat. Chem. 2018, 10, 1164. DOI: 10.1038/s41557-018-0123-7


79. Activation of diverse carbon–heteroatom and carbon–carbon bonds via palladium( ii )-catalysed β-X elimination

Van T. Tran; John A. Gurak; Kin S. Yang; Keary M. Engle. Nat. Chem. 2018, 10, 1126. DOI: 10.1038/s41557-018-0110-z


J. Am. Chem. Soc.


80. Competing Hydrogen-Bond Polarities in a Dynamic Oligourea Foldamer: A Molecular Spring Torsion Balance

Romina Wechsel; Matej Žabka; John W. Ward; Jonathan Clayden. J. Am. Chem. Soc. 2018, 140, 3528–3531. DOI: 10.1021/jacs.8b00567


81. Enantioselective, Lewis Base-Catalyzed Sulfenocyclization of Polyenes

Zhonglin Tao; Kevin A. Robb; Kuo Zhao; Scott E. Denmark. J. Am. Chem. Soc. 2018, 140, 3569–3573. DOI: 10.1021/jacs.8b01660


82. Chirality-Amplifying, Dynamic Induction of Single-Handed Helix by Chiral Guests to Macromolecular Chiral Catalysts Bearing Boronyl Pendants as Receptor Sites

Takeshi Yamamoto; Ryo Murakami; Satoko Komatsu; Michinori Suginome. J. Am. Chem. Soc. 2018, 140, 3867–3870. DOI: 10.1021/jacs.8b00529


83. Ion–Hydrocarbon and/or Ion–Ion Interactions: Direct and Reverse Hofmeister Effects in a Synthetic Host

Jacobs H. Jordan; Corinne L. D. Gibb; Anthony Wishard; Thu Pham; Bruce C. Gibb. J. Am. Chem. Soc. 2018, 140, 4092–4099. DOI: 10.1021/jacs.8b00196


84. Thermal, Catalytic Conversion of Alkanes to Linear Aldehydes and Linear Amines

Xinxin Tang; Xiangqing Jia; Zheng Huang. J. Am. Chem. Soc. 2018, 140, 4157–4163. DOI: 10.1021/jacs.8b01526


85. Cobalt(II)-Catalyzed Electrooxidative C–H Amination of Arenes with Alkylamines

Xinlong Gao; Pan Wang; Li Zeng; Shan Tang; Aiwen Lei. J. Am. Chem. Soc. 2018, 140, 4195–4199. DOI: 10.1021/jacs.7b13049


86. A General Strategy for Aliphatic C–H Functionalization Enabled by Organic Photoredox Catalysis

Kaila A. Margrey; William L. Czaplyski; David A. Nicewicz; Erik J. Alexanian. J. Am. Chem. Soc. 2018, 140, 4213–4217. DOI: 10.1021/jacs.8b00592


87. Elucidating the Role of the Boronic Esters in the Suzuki–Miyaura Reaction: Structural, Kinetic, and Computational Investigations

Andy A. Thomas; Andrew F. Zahrt; Connor P. Delaney; Scott E. Denmark. J. Am. Chem. Soc. 2018, 140, 4401–4416. DOI: 10.1021/jacs.8b00400


88. Transfer Hydrogenation of Alkenes Using Ethanol Catalyzed by a NCP Pincer Iridium Complex: Scope and Mechanism

Yulei Wang; Zhidao Huang; Xuebing Leng; Huping Zhu; Guixia Liu; Zheng Huang. J. Am. Chem. Soc. 2018, 140, 4417–4429. DOI: 10.1021/jacs.8b01038


89. Nickel-Catalyzed Dearomative trans-1,2-Carboamination

Lucas W. Hernandez; Ulrich Klöckner; Jola Pospech; Lilian Hauss; David Sarlah. J. Am. Chem. Soc. 2018, 140, 4503–4507. DOI: 10.1021/jacs.8b01726


90. Enantioselective Radical Cyclization for Construction of 5-Membered Ring Structures by Metalloradical C–H Alkylation

Yong Wang; Xin Wen; Xin Cui; X. Peter Zhang. J. Am. Chem. Soc. 2018, 140, 4792–4796. DOI: 10.1021/jacs.8b01662


91. Case for Lithium Tetramethylpiperidide-Mediated Ortholithiations: Reactivity and Mechanisms

Kyle A. Mack; David B. Collum. J. Am. Chem. Soc. 2018, 140, 4877–4883. DOI: 10.1021/jacs.8b00590


92. Synergistic Anion–(π)n–π Catalysis on π-Stacked Foldamers

Anna-Bea Bornhof; Antonio Bauzá; Alexander Aster; Marion Pupier; Antonio Frontera; Eric Vauthey; Naomi Sakai; Stefan Matile. J. Am. Chem. Soc. 2018, 140, 4884–4892. DOI: 10.1021/jacs.8b00809


93. Chiral Selenide-Catalyzed Enantioselective Allylic Reaction and Intermolecular Difunctionalization of Alkenes: Efficient Construction of C-SCF3 Stereogenic Molecules

Xiang Liu; Yaoyu Liang; Jieying Ji; Jie Luo; Xiaodan Zhao. J. Am. Chem. Soc. 2018, 140, 4782–4786. DOI: 10.1021/jacs.8b01513


94. The True Catalyst Revealed: The Intervention of Chiral Ca and Mg Phosphates in Brønsted Acid Promoted Asymmetric Mannich Reactions

Luis Simón; Robert S. Paton. J. Am. Chem. Soc. 2018, 140, 5412–5420. DOI: 10.1021/jacs.7b13678


95. Stereospecific Ring Contraction of Bromocycloheptenes through Dyotropic Rearrangements via Nonclassical Carbocation–Anion Pairs

Shermin S. Goh; Pier Alexandre Champagne; Sureshbabu Guduguntla; Takashi Kikuchi; Makoto Fujita; K. N. Houk; Ben L. Feringa. J. Am. Chem. Soc. 2018, 140, 4986–4990. DOI: 10.1021/jacs.8b00821


96. Deoxyfluorination with Sulfonyl Fluorides: Navigating Reaction Space with Machine Learning

Matthew K. Nielsen; Derek T. Ahneman; Orestes Riera; Abigail G. Doyle. J. Am. Chem. Soc. 2018, 140, 5004–5008. DOI: 10.1021/jacs.8b01523


97. Asymmetric Cu-Catalyzed 1,4-Dearomatization of Pyridines and Pyridazines without Preactivation of the Heterocycle or Nucleophile

Michael W. Gribble; Sheng Guo; Stephen L. Buchwald. J. Am. Chem. Soc. 2018, 140, 5057–5060. DOI: 10.1021/jacs.8b02568


98. Catalyst-Directed Guidance of Sulfur-Substituted Enediolates to Stereoselective Carbon–Carbon Bond Formation with Aldehydes

Daisuke Uraguchi; Kohei Yamada; Makoto Sato; Takashi Ooi. J. Am. Chem. Soc. 2018, 140, 5110–5117. DOI: 10.1021/jacs.7b12949


99. Arylketone π-Conjugation Controls Enantioselectivity in Asymmetric Alkynylations Catalyzed by Centrochiral Ruthenium Complexes

Shuming Chen; Yu Zheng; Tianjiao Cui; Eric Meggers; K. N. Houk. J. Am. Chem. Soc. 2018, 140, 5146–5152. DOI: 10.1021/jacs.8b00485


100. Scope and Mechanism of a True Organocatalytic Beckmann Rearrangement with a Boronic Acid/Perfluoropinacol System under Ambient Conditions

Xiaobin Mo; Timothy D. R. Morgan; Hwee Ting Ang; Dennis G. Hall. J. Am. Chem. Soc. 2018, 140, 5264–5271. DOI: 10.1021/jacs.8b01618


101. Selective Radical Trifluoromethylation of Native Residues in Proteins

Mateusz Imiołek; Gogulan Karunanithy; Wai-Lung Ng; Andrew J. Baldwin; Véronique Gouverneur; Benjamin G. Davis. J. Am. Chem. Soc. 2018, 140, 1568–1571. DOI: 10.1021/jacs.7b10230


102. 18F-Trifluoromethylation of Unmodified Peptides with 5-18F-(Trifluoromethyl)dibenzothiophenium Trifluoromethanesulfonate

Stefan Verhoog; Choon Wee Kee; Yanlan Wang; Tanatorn Khotavivattana; Thomas C. Wilson; Veerle Kersemans; Sean Smart; Matthew Tredwell; Benjamin G. Davis; Véronique Gouverneur. J. Am. Chem. Soc. 2018, 140, 1572–1575. DOI: 10.1021/jacs.7b10227


103. δ-Selective Functionalization of Alkanols Enabled by Visible-Light-Induced Ligand-to-Metal Charge Transfer

Anhua Hu; Jing-Jing Guo; Hui Pan; Haoming Tang; Zhaobo Gao; Zhiwei Zuo. J. Am. Chem. Soc. 2018, 140, 1612–1616. DOI: 10.1021/jacs.7b13131


104. Mechanistic Insight Facilitates Discovery of a Mild and Efficient Copper-Catalyzed Dehydration of Primary Amides to Nitriles Using Hydrosilanes

Richard Y. Liu; Minwoo Bae; Stephen L. Buchwald. J. Am. Chem. Soc. 2018, 140, 1627–1631. DOI: 10.1021/jacs.8b00643


105. Hydrogen Atom Transfer by a High-Valent Nickel-Chloride Complex

Prasenjit Mondal; Paolo Pirovano; Ankita Das; Erik R. Farquhar; Aidan R. McDonald. J. Am. Chem. Soc. 2018, 140, 1834–1841. DOI: 10.1021/jacs.7b11953


106. Chemical Exchange Saturation Transfer in Chemical Reactions: A Mechanistic Tool for NMR Detection and Characterization of Transient Intermediates

N. Lokesh; Andreas Seegerer; Johnny Hioe; Ruth M. Gschwind. J. Am. Chem. Soc. 2018, 140, 1855–1862. DOI: 10.1021/jacs.7b12343


107. Enantioselective Total Syntheses of (+)-Hippolachnin A, (+)-Gracilioether A, (−)-Gracilioether E, and (−)-Gracilioether F

Qingong Li; Kun Zhao; Anssi Peuronen; Kari Rissanen; Dieter Enders; Yefeng Tang. J. Am. Chem. Soc. 2018, 140, 1937–1944. DOI: 10.1021/jacs.7b12903


108. Enantioselective 1,2-Anionotropic Rearrangement of Acylsilane through a Bisguanidinium Silicate Ion Pair

Weidi Cao; Davin Tan; Richmond Lee; Choon-Hong Tan. J. Am. Chem. Soc. 2018, 140, 1952–1955. DOI: 10.1021/jacs.7b13056


109. A Strategy for the Convergent and Stereoselective Assembly of Polycyclic Molecules

Emily E. Robinson; Regan J. Thomson. J. Am. Chem. Soc. 2018, 140, 1956–1965. DOI: 10.1021/jacs.7b13234


110. A General Strategy for Site-Selective Incorporation of Deuterium and Tritium into Pyridines, Diazines, and Pharmaceuticals

J. Luke Koniarczyk; David Hesk; Alix Overgard; Ian W. Davies; Andrew McNally. J. Am. Chem. Soc. 2018, 140, 1990–1993. DOI: 10.1021/jacs.7b11710


111. Biomimetic Desymmetrization of a Carboxylic Acid

Matthew T. Knowe; Michael W. Danneman; Sarah Sun; Maren Pink; Jeffrey N. Johnston. J. Am. Chem. Soc. 2018, 140, 1998–2001. DOI: 10.1021/jacs.7b12185


112. A Regio- and Enantioselective CuH-Catalyzed Ketone Allylation with Terminal Allenes

Erica Y. Tsai; Richard Y. Liu; Yang Yang; Stephen L. Buchwald. J. Am. Chem. Soc. 2018, 140, 2007–2011. DOI: 10.1021/jacs.7b12271


113. Asymmetric Synthesis of Chiral Primary Amines by Ruthenium-Catalyzed Direct Reductive Amination of Alkyl Aryl Ketones with Ammonium Salts and Molecular H2

Xuefeng Tan; Shuang Gao; Weijun Zeng; Shan Xin; Qin Yin; Xumu Zhang. J. Am. Chem. Soc. 2018, 140, 2024–2027. DOI: 10.1021/jacs.7b12898


114. Ni-Catalyzed Site-Selective Dicarboxylation of 1,3-Dienes with CO2

Andreu Tortajada; Ryo Ninokata; Ruben Martin. J. Am. Chem. Soc. 2018, 140, 2050–2053. DOI: 10.1021/jacs.7b13220


115. Total Synthesis of (−)-Xylogranatopyridine B via a Palladium-Catalyzed Oxidative Stannylation of Enones

Alexander W. Schuppe; David Huang; Yifeng Chen; Timothy R. Newhouse. J. Am. Chem. Soc. 2018, 140, 2062–2066. DOI: 10.1021/jacs.7b13189


116. Scalable Access to Arylomycins via C–H Functionalization Logic

David S. Peters; Floyd E. Romesberg; Phil S. Baran. J. Am. Chem. Soc. 2018, 140, 2072–2075. DOI: 10.1021/jacs.8b00087


117. Ir/Cu Dual Catalysis: Enantio- and Diastereodivergent Access to α,α-Disubstituted α-Amino Acids Bearing Vicinal Stereocenters

Xiaohong Huo; Jiacheng Zhang; Jingke Fu; Rui He; Wanbin Zhang. J. Am. Chem. Soc. 2018, 140, 2080–2084. DOI: 10.1021/jacs.8b00187


118. Enantioselective Regiodivergent Synthesis of Chiral Pyrrolidines with Two Quaternary Stereocenters via Ligand-Controlled Copper(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloadditions

Shan Xu; Zhan-Ming Zhang; Bing Xu; Bing Liu; Yuanyuan Liu; Junliang Zhang. J. Am. Chem. Soc. 2018, 140, 2272–2283. DOI: 10.1021/jacs.7b12137


119. Ni-Catalyzed Carbon–Carbon Bond-Forming Reductive Amination

Christoph Heinz; J. Patrick Lutz; Eric M. Simmons; Michael M. Miller; William R. Ewing; Abigail G. Doyle. J. Am. Chem. Soc. 2018, 140, 2292–2300. DOI: 10.1021/jacs.7b12212


120. Anodically Coupled Electrolysis for the Heterodifunctionalization of Alkenes

Ke-Yin Ye; Gisselle Pombar; Niankai Fu; Gregory S. Sauer; Ivan Keresztes; Song Lin. J. Am. Chem. Soc. 2018, 140, 2438–2441. DOI: 10.1021/jacs.7b13387


121. Multimetallic Ni- and Pd-Catalyzed Cross-Electrophile Coupling To Form Highly Substituted 1,3-Dienes

Astrid M. Olivares; Daniel J. Weix. J. Am. Chem. Soc. 2018, 140, 2446–2449. DOI: 10.1021/jacs.7b13601


122. Electrochemical Difluoromethylarylation of Alkynes

Peng Xiong; He-Huan Xu; Jinshuai Song; Hai-Chao Xu. J. Am. Chem. Soc. 2018, 140, 2460–2464. DOI: 10.1021/jacs.8b00391


123. General, Mild, and Selective Method for Desaturation of Aliphatic Amines

Padon Chuentragool; Marvin Parasram; Yi Shi; Vladimir Gevorgyan. J. Am. Chem. Soc. 2018, 140, 2465–2468. DOI: 10.1021/jacs.8b00488


124. Chiral Phosphoric Acid Catalyzed Enantioselective Ring Expansion Reaction of 1,3-Dithiane Derivatives: Case Study of the Nature of Ion-Pairing Interaction

Feng Li; Toshinobu Korenaga; Taishi Nakanishi; Jun Kikuchi; Masahiro Terada. J. Am. Chem. Soc. 2018, 140, 2629–2642. DOI: 10.1021/jacs.7b13274


125. Enantioselective Synthesis of Trisubstituted Allenyl–B(pin) Compounds by Phosphine–Cu-Catalyzed 1,3-Enyne Hydroboration. Insights Regarding Stereochemical Integrity of Cu–Allenyl Intermediates

Youming Huang; Juan del Pozo; Sebastian Torker; Amir H. Hoveyda. J. Am. Chem. Soc. 2018, 140, 2643–2655. DOI: 10.1021/jacs.7b13296


126. Transition-Metal-Free Suzuki-Type Cross-Coupling Reaction of Benzyl Halides and Boronic Acids via 1,2-Metalate Shift

Zhiqi He; Feifei Song; Huan Sun; Yong Huang. J. Am. Chem. Soc. 2018, 140, 2693–2699. DOI: 10.1021/jacs.8b00380


127. Enantioselective 1,2-Difunctionalization of 1,3-Butadiene by Sequential Alkylation and Carbonyl Allylation

Yang Xiong; Guozhu Zhang. J. Am. Chem. Soc. 2018, 140, 2735–2738. DOI: 10.1021/jacs.7b12760


128. Modular Access to Azepines by Directed Carbonylative C–C Bond Activation of Aminocyclopropanes

Gang-Wei Wang; John F. Bower. J. Am. Chem. Soc. 2018, 140, 2743–2747. DOI: 10.1021/jacs.7b13087


129. Selective Synthesis of Divergolide I

Daniel W. Terwilliger; Dirk Trauner. J. Am. Chem. Soc. 2018, 140, 2748–2751. DOI: 10.1021/jacs.7b13092


130. Enantioselective Intermolecular Pd-Catalyzed Hydroalkylation of Acyclic 1,3-Dienes with Activated Pronucleophiles

Nathan J. Adamson; Katherine C. E. Wilbur; Steven J. Malcolmson. J. Am. Chem. Soc. 2018, 140, 2761–2764. DOI: 10.1021/jacs.7b13300


131. Molecular Design, Synthesis, and Asymmetric Catalysis of a Hexacoordinated Chiral Phosphate Ion

Daisuke Uraguchi; Hitoshi Sasaki; Yuto Kimura; Takaki Ito; Takashi Ooi. J. Am. Chem. Soc. 2018, 140, 2765–2768. DOI: 10.1021/jacs.7b13433


132. Dianionic Phase-Transfer Catalyst for Asymmetric Fluoro-cyclization

Hiromichi Egami; Tomoki Niwa; Hitomi Sato; Ryo Hotta; Daiki Rouno; Yuji Kawato; Yoshitaka Hamashima. J. Am. Chem. Soc. 2018, 140, 2785–2788. DOI: 10.1021/jacs.7b13690


133. Pd-Catalyzed, ortho C–H Methylation and Fluorination of Benzaldehydes Using Orthanilic Acids as Transient Directing Groups

Xiao-Yang Chen; Erik J. Sorensen. J. Am. Chem. Soc. 2018, 140, 2789–2792. DOI: 10.1021/jacs.8b00048


134. Lithium Amino Alkoxide–Evans Enolate Mixed Aggregates: Aldol Addition with Matched and Mismatched Stereocontrol

Janis Jermaks; Evan H. Tallmadge; Ivan Keresztes; David B. Collum. J. Am. Chem. Soc. 2018, 140, 3077–3090. DOI: 10.1021/jacs.7b13776


135. Total Synthesis of (−)-Chromodorolide B By a Computationally-Guided Radical Addition/Cyclization/Fragmentation Cascade

Daniel J. Tao; Yuriy Slutskyy; Mikko Muuronen; Alexander Le; Philipp Kohler; Larry E. Overman. J. Am. Chem. Soc. 2018, 140, 3091–3102. DOI: 10.1021/jacs.7b13799


136. Biphilic Organophosphorus-Catalyzed Intramolecular Csp2–H Amination: Evidence for a Nitrenoid in Catalytic Cadogan Cyclizations

Trevor V. Nykaza; Antonio Ramirez; Tyler S. Harrison; Michael R. Luzung; Alexander T. Radosevich. J. Am. Chem. Soc. 2018, 140, 3103–3113. DOI: 10.1021/jacs.7b13803


137. Iridium-Catalyzed Intramolecular Asymmetric Allylic Alkylation of Hydroxyquinolines: Simultaneous Weakening of the Aromaticity of Two Consecutive Aromatic Rings

Ze-Peng Yang; Ru Jiang; Chao Zheng; Shu-Li You. J. Am. Chem. Soc. 2018, 140, 3114–3119. DOI: 10.1021/jacs.8b00136


138. Hydrophosphorylation of Alkynes Catalyzed by Palladium: Generality and Mechanism

Tieqiao Chen; Chang-Qiu Zhao; Li-Biao Han. J. Am. Chem. Soc. 2018, 140, 3139–3155. DOI: 10.1021/jacs.8b00550


139. Chelate-Assisted Ring-Closing Metathesis: A Strategy for Accelerating Macrocyclization at Ambient Temperatures

Carolyn S. Higman; Daniel L. Nascimento; Benjamin J. Ireland; Stephan Audörsch; Gwendolyn A. Bailey; Robert McDonald; Deryn E. Fogg. J. Am. Chem. Soc. 2018, 140, 1604–1607. DOI: 10.1021/jacs.7b13257


140. δ-Selective Functionalization of Alkanols Enabled by Visible-Light-Induced Ligand-to-Metal Charge Transfer

Anhua Hu; Jing-Jing Guo; Hui Pan; Haoming Tang; Zhaobo Gao; Zhiwei Zuo. J. Am. Chem. Soc. 2018, 140, 1612–1616. DOI: 10.1021/jacs.7b13131


141. Chemical Exchange Saturation Transfer in Chemical Reactions: A Mechanistic Tool for NMR Detection and Characterization of Transient Intermediates

N. Lokesh; Andreas Seegerer; Johnny Hioe; Ruth M. Gschwind. J. Am. Chem. Soc. 2018, 140, 1855–1862. DOI: 10.1021/jacs.7b12343


142. Enantioselective Total Syntheses of (+)-Hippolachnin A, (+)-Gracilioether A, (−)-Gracilioether E, and (−)-Gracilioether F

Qingong Li; Kun Zhao; Anssi Peuronen; Kari Rissanen; Dieter Enders; Yefeng Tang. J. Am. Chem. Soc. 2018, 140, 1937–1944. DOI: 10.1021/jacs.7b12903


143. Enantioselective 1,2-Anionotropic Rearrangement of Acylsilane through a Bisguanidinium Silicate Ion Pair

Weidi Cao; Davin Tan; Richmond Lee; Choon-Hong Tan. J. Am. Chem. Soc. 2018, 140, 1952–1955. DOI: 10.1021/jacs.7b13056


144. A General Strategy for Site-Selective Incorporation of Deuterium and Tritium into Pyridines, Diazines, and Pharmaceuticals

J. Luke Koniarczyk; David Hesk; Alix Overgard; Ian W. Davies; Andrew McNally. J. Am. Chem. Soc. 2018, 140, 1990–1993. DOI: 10.1021/jacs.7b11710


145. A Coupling Approach for the Generation of α,α-Bis(enolate) Equivalents: Regioselective Synthesis of gem-Difunctionalized Ketones

Carmelo E. Iacono; Thomas C. Stephens; Teena S. Rajan; Graham Pattison. J. Am. Chem. Soc. 2018, 140, 2036–2040. DOI: 10.1021/jacs.7b12941


146. Ir/Cu Dual Catalysis: Enantio- and Diastereodivergent Access to α,α-Disubstituted α-Amino Acids Bearing Vicinal Stereocenters

Xiaohong Huo; Jiacheng Zhang; Jingke Fu; Rui He; Wanbin Zhang. J. Am. Chem. Soc. 2018, 140, 2080–2084. DOI: 10.1021/jacs.8b00187


147. Enantioselective Regiodivergent Synthesis of Chiral Pyrrolidines with Two Quaternary Stereocenters via Ligand-Controlled Copper(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloadditions

Shan Xu; Zhan-Ming Zhang; Bing Xu; Bing Liu; Yuanyuan Liu; Junliang Zhang. J. Am. Chem. Soc. 2018, 140, 2272–2283. DOI: 10.1021/jacs.7b12137


148. Anodically Coupled Electrolysis for the Heterodifunctionalization of Alkenes

Ke-Yin Ye; Gisselle Pombar; Niankai Fu; Gregory S. Sauer; Ivan Keresztes; Song Lin. J. Am. Chem. Soc. 2018, 140, 2438–2441. DOI: 10.1021/jacs.7b13387


149. Chiral Phosphoric Acid Catalyzed Enantioselective Ring Expansion Reaction of 1,3-Dithiane Derivatives: Case Study of the Nature of Ion-Pairing Interaction

Feng Li; Toshinobu Korenaga; Taishi Nakanishi; Jun Kikuchi; Masahiro Terada. J. Am. Chem. Soc. 2018, 140, 2629–2642. DOI: 10.1021/jacs.7b13274


150. Enantioselective 1,2-Difunctionalization of 1,3-Butadiene by Sequential Alkylation and Carbonyl Allylation

Yang Xiong; Guozhu Zhang. J. Am. Chem. Soc. 2018, 140, 2735–2738. DOI: 10.1021/jacs.7b12760


151. Enantioselective Intermolecular Pd-Catalyzed Hydroalkylation of Acyclic 1,3-Dienes with Activated Pronucleophiles

Nathan J. Adamson; Katherine C. E. Wilbur; Steven J. Malcolmson. J. Am. Chem. Soc. 2018, 140, 2761–2764. DOI: 10.1021/jacs.7b13300


152. Pd-Catalyzed, ortho C–H Methylation and Fluorination of Benzaldehydes Using Orthanilic Acids as Transient Directing Groups

Xiao-Yang Chen; Erik J. Sorensen. J. Am. Chem. Soc. 2018, 140, 2789–2792. DOI: 10.1021/jacs.8b00048


153. (Guanidine)copper Complex-Catalyzed Enantioselective Dynamic Kinetic Allylic Alkynylation under Biphasic Condition

Xi-Yang Cui; Yicen Ge; Siu Min Tan; Huan Jiang; Davin Tan; Yunpeng Lu; Richmond Lee; Choon-Hong Tan. J. Am. Chem. Soc. 2018, 140, 8448–8455. DOI: 10.1021/jacs.7b12806


154. Deconvoluting the Role of Charge in a Supramolecular Catalyst

Cynthia M. Hong; Mariko Morimoto; Eugene A. Kapustin; Nicola Alzakhem; Robert G. Bergman; Kenneth N. Raymond; F. Dean Toste. J. Am. Chem. Soc. 2018, 140, 6591–6595. DOI: 10.1021/jacs.8b01701


155. Cobalt-Catalyzed Regioselective Olefin Isomerization Under Kinetic Control

Xufang Liu; Wei Zhang; Yujie Wang; Ze-Xin Zhang; Lei Jiao; Qiang Liu. J. Am. Chem. Soc. 2018, 140, 6873–6882. DOI: 10.1021/jacs.8b01815


156. Total Synthesis of the Norhasubanan Alkaloid Stephadiamine

Nina Hartrampf; Nils Winter; Gabriele Pupo; Brian M. Stoltz; Dirk Trauner. J. Am. Chem. Soc. 2018, 140, 8675–8680. DOI: 10.1021/jacs.8b01918


157. C(alkenyl)–H Activation via Six-Membered Palladacycles: Catalytic 1,3-Diene Synthesis

Mingyu Liu; Pusu Yang; Malkanthi K. Karunananda; Yanyan Wang; Peng Liu; Keary M. Engle. J. Am. Chem. Soc. 2018, 140, 5805–5813. DOI: 10.1021/jacs.8b02124


158. Electrochemically Switchable Ring-Opening Polymerization of Lactide and Cyclohexene Oxide

Miao Qi; Qi Dong; Dunwei Wang; Jeffery A. Byers. J. Am. Chem. Soc. 2018, 140, 5686–5690. DOI: 10.1021/jacs.8b02171


159. Chiral Brønsted Acid Catalyzed Enantioselective Dehydrative Nazarov-Type Electrocyclization of Aryl and 2-Thienyl Vinyl Alcohols

Jianwen Jin; Yichao Zhao; Ali Gouranourimi; Alireza Ariafard; Philip Wai Hong Chan. J. Am. Chem. Soc. 2018, 140, 5834–5841. DOI: 10.1021/jacs.8b02339


160. Asymmetric Synthesis of Gonytolide A: Strategic Use of an Aryl Halide Blocking Group for Oxidative Coupling

Xiaowei Wu; Takayuki Iwata; Adam Scharf; Tian Qin; Kyle D. Reichl; John A. Porco. J. Am. Chem. Soc. 2018, 140, 5969–5975. DOI: 10.1021/jacs.8b02535


161. Enantioselective Halo-oxy- and Halo-azacyclizations Induced by Chiral Amidophosphate Catalysts and Halo-Lewis Acids

Yanhui Lu; Hidefumi Nakatsuji; Yukimasa Okumura; Lu Yao; Kazuaki Ishihara. J. Am. Chem. Soc. 2018, 140, 6039–6043. DOI: 10.1021/jacs.8b02607


162. Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids

Jacob A. Kautzky; Tao Wang; Ryan W. Evans; David W. C. MacMillan. J. Am. Chem. Soc. 2018, 140, 6522–6526. DOI: 10.1021/jacs.8b02650


163. Formation of Chiral Allylic Ethers via an Enantioselective Palladium-Catalyzed Alkenylation of Acyclic Enol Ethers

Harshkumar H. Patel; Matthew B. Prater; Scott O. Squire; Matthew S. Sigman. J. Am. Chem. Soc. 2018, 140, 5895–5898. DOI: 10.1021/jacs.8b02751


164. Palladium-Catalyzed Enantioselective Relay Heck Arylation of Enelactams: Accessing α,β-Unsaturated δ-Lactams

Qianjia Yuan; Matthew S. Sigman. J. Am. Chem. Soc. 2018, 140, 6527–6530. DOI: 10.1021/jacs.8b02752


165. Chemo- and Enantioselective Pd/B Hybrid Catalysis for the Construction of Acyclic Quaternary Carbons: Migratory Allylation of O-Allyl Esters to α-C-Allyl Carboxylic Acids

Taiki Fujita; Tomohiro Yamamoto; Yuya Morita; Hongyu Chen; Yohei Shimizu; Motomu Kanai. J. Am. Chem. Soc. 2018, 140, 5899–5903. DOI: 10.1021/jacs.8b02783


166. Asymmetric Aza-Wacker-Type Cyclization of N-Ts Hydrazine-Tethered Tetrasubstituted Olefins: Synthesis of Pyrazolines Bearing One Quaternary or Two Vicinal Stereocenters

Xuezhen Kou; Qihang Shao; Chenghao Ye; Guoqiang Yang; Wanbin Zhang. J. Am. Chem. Soc. 2018, 140, 7587–7597. DOI: 10.1021/jacs.8b02865


167. Re(I)-Catalyzed Hydropropargylation of Silyl Enol Ethers Utilizing Dynamic Interconversion of Vinylidene–Alkenylmetal Intermediates via 1,5-Hydride Transfer

Nobuharu Iwasawa; Shoya Watanabe; Akane Ario; Hideyuki Sogo. J. Am. Chem. Soc. 2018, 140, 7769–7772. DOI: 10.1021/jacs.8b02903


168. Desymmetrization of meso-Dibromocycloalkenes through Copper(I)-Catalyzed Asymmetric Allylic Substitution with Organolithium Reagents

Shermin S. Goh; Sureshbabu Guduguntla; Takashi Kikuchi; Martin Lutz; Edwin Otten; Makoto Fujita; Ben L. Feringa. J. Am. Chem. Soc. 2018, 140, 7052–7055. DOI: 10.1021/jacs.8b02992


169. Production of Formamides from CO and Amines Induced by Porphyrin Rhodium(II) Metalloradical

Jiajing Zhang; Wentao Zhang; Minghui Xu; Yang Zhang; Xuefeng Fu; Huayi Fang. J. Am. Chem. Soc. 2018, 140, 6656–6660. DOI: 10.1021/jacs.8b03029


170. An Enantioselective Cross-Dehydrogenative Coupling Catalysis Approach to Substituted Tetrahydropyrans

Ansoo Lee; Rick C. Betori; Erika A. Crane; Karl A. Scheidt. J. Am. Chem. Soc. 2018, 140, 6212–6216. DOI: 10.1021/jacs.8b03063


171. Ni-Catalyzed Regioselective β,δ-Diarylation of Unactivated Olefins in Ketimines via Ligand-Enabled Contraction of Transient Nickellacycles: Rapid Access to Remotely Diarylated Ketones

Prakash Basnet; Roshan K. Dhungana; Surendra Thapa; Bijay Shrestha; Shekhar KC; Jeremiah M. Sears; Ramesh Giri. J. Am. Chem. Soc. 2018, 140, 7782–7786. DOI: 10.1021/jacs.8b03163


172. Synthesis, Reactivity, Functionalization, and ADMET Properties of Silicon-Containing Nitrogen Heterocycles

Scott J. Barraza; Scott E. Denmark. J. Am. Chem. Soc. 2018, 140, 6668–6684. DOI: 10.1021/jacs.8b03187


173. Organocatalytic Enantioselective Construction of Axially Chiral Sulfone-Containing Styrenes

Shiqi Jia; Zhili Chen; Nan Zhang; Yu Tan; Yidong Liu; Jun Deng; Hailong Yan. J. Am. Chem. Soc. 2018, 140, 7056–7060. DOI: 10.1021/jacs.8b03211


174. Dearomative Cascade Photocatalysis: Divergent Synthesis through Catalyst Selective Energy Transfer

Michael J. James; Jonas Luca Schwarz; Felix Strieth-Kalthoff; Birgit Wibbeling; Frank Glorius. J. Am. Chem. Soc. 2018, 140, 8624–8628. DOI: 10.1021/jacs.8b03302


175. Transition Metal-Free 1,2-Carboboration of Unactivated Alkenes

Ying Cheng; Christian Mück-Lichtenfeld; Armido Studer. J. Am. Chem. Soc. 2018, 140, 6221–6225. DOI: 10.1021/jacs.8b03333


176. From Borapyramidane to Borole Dianion

Vladimir Ya. Lee; Haruka Sugasawa; Olga A. Gapurenko; Ruslan M. Minyaev; Vladimir I. Minkin; Heinz Gornitzka; Akira Sekiguchi. J. Am. Chem. Soc. 2018, 140, 6053–6056. DOI: 10.1021/jacs.8b03473


177. Pd(II)-Catalyzed Enantioselective C(sp3)–H Arylation of Free Carboxylic Acids

Peng-Xiang Shen; Liang Hu; Qian Shao; Kai Hong; Jin-Quan Yu. J. Am. Chem. Soc. 2018, 140, 6545–6549. DOI: 10.1021/jacs.8b03509


178. Direct β-Alkylation of Ketones and Aldehydes via Pd-Catalyzed Redox Cascade

Chengpeng Wang; Guangbin Dong. J. Am. Chem. Soc. 2018, 140, 6057–6061. DOI: 10.1021/jacs.8b03530


179. Mechanism of Ti-Catalyzed Oxidative Nitrene Transfer in [2 + 2 + 1] Pyrrole Synthesis from Alkynes and Azobenzene

Zachary W. Davis-Gilbert; Xuelan Wen; Jason D. Goodpaster; Ian A. Tonks. J. Am. Chem. Soc. 2018, 140, 7267–7281. DOI: 10.1021/jacs.8b03546


180. Main-Group-Catalyzed Reductive Alkylation of Multiply Substituted Amines with Aldehydes Using H2

Yoichi Hoshimoto; Takuya Kinoshita; Sunit Hazra; Masato Ohashi; Sensuke Ogoshi. J. Am. Chem. Soc. 2018, 140, 7292–7300. DOI: 10.1021/jacs.8b03626


181. Palladium-Catalyzed Asymmetric Allylic Alkylation of 3-Substituted 1H-Indoles and Tryptophan Derivatives with Vinylcyclopropanes

Barry M. Trost; Wen-Ju Bai; Christoph Hohn; Yu Bai; James J. Cregg. J. Am. Chem. Soc. 2018, 140, 6710–6717. DOI: 10.1021/jacs.8b03656


182. Direct Access to Versatile Electrophiles via Catalytic Oxidative Cyanation of Alkenes

De-Wei Gao; Ekaterina V. Vinogradova; Sri Krishna Nimmagadda; Jose M. Medina; Yiyang Xiao; Radu M. Suciu; Benjamin F. Cravatt; Keary M. Engle. J. Am. Chem. Soc. 2018, 140, 8069–8073. DOI: 10.1021/jacs.8b03704


183. Manganese-Mediated Reductive Transamidation of Tertiary Amides with Nitroarenes

Chi Wai Cheung; Jun-An Ma; Xile Hu. J. Am. Chem. Soc. 2018, 140, 6789–6792. DOI: 10.1021/jacs.8b03739


184. C–N Cross-Coupling via Photoexcitation of Nickel–Amine Complexes

Chern-Hooi Lim; Max Kudisch; Bin Liu; Garret M. Miyake. J. Am. Chem. Soc. 2018, 140, 7667–7673. DOI: 10.1021/jacs.8b03744


185. Elucidation of the Formation Mechanisms of the Octahydrotriborate Anion (B3H8) through the Nucleophilicity of the B–H Bond

Xi-Meng Chen; Nana Ma; Qian-Fan Zhang; Jin Wang; Xiaoge Feng; Changgeng Wei; Lai-Sheng Wang; Jie Zhang; Xuenian Chen. J. Am. Chem. Soc. 2018, 140, 6718–6726. DOI: 10.1021/jacs.8b03785


186. CO Oxidation by N2O Homogeneously Catalyzed by Ruthenium Hydride Pincer Complexes Indicating a New Mechanism

Rong Zeng; Moran Feller; Yael Diskin-Posner; Linda J. W. Shimon; Yehoshoa Ben-David; David Milstein. J. Am. Chem. Soc. 2018, 140, 7061–7064. DOI: 10.1021/jacs.8b03927


187. Mechanistic Studies of Palladium-Catalyzed Aminocarbonylation of Aryl Chlorides with Carbon Monoxide and Ammonia

Justin Y. Wang; Alexandra E. Strom; John F. Hartwig. J. Am. Chem. Soc. 2018, 140, 7979–7993. DOI: 10.1021/jacs.8b04073


188. Modular ipso/ortho Difunctionalization of Aryl Bromides via Palladium/Norbornene Cooperative Catalysis

Zhe Dong; Gang Lu; Jianchun Wang; Peng Liu; Guangbin Dong. J. Am. Chem. Soc. 2018, 140, 8551–8562. DOI: 10.1021/jacs.8b04153


189. Rhodium Complexes Bearing PAlP Pincer Ligands

Naofumi Hara; Teruhiko Saito; Kazuhiko Semba; Nishamol Kuriakose; Hong Zheng; Shigeyoshi Sakaki; Yoshiaki Nakao. J. Am. Chem. Soc. 2018, 140, 7070–7073. DOI: 10.1021/jacs.8b04199


190. Stereodivergent Rhodium(III)-Catalyzed cis-Cyclopropanation Enabled by Multivariate Optimization

Tiffany Piou; Fedor Romanov-Michailidis; Melissa A. Ashley; Maria Romanova-Michaelides; Tomislav Rovis. J. Am. Chem. Soc. 2018, 140, 9587–9593. DOI: 10.1021/jacs.8b04243


191. Intermediacy of Ni–Ni Species in sp2 C–O Bond Cleavage of Aryl Esters: Relevance in Catalytic C–Si Bond Formation

Rosie J. Somerville; Lillian V. A. Hale; Enrique Gómez-Bengoa; Jordi Burés; Ruben Martin. J. Am. Chem. Soc. 2018, 140, 8771–8780. DOI: 10.1021/jacs.8b04479


192. Selective Hydrogenation of Cyclic Imides to Diols and Amines and Its Application in the Development of a Liquid Organic Hydrogen Carrier

Amit Kumar; Trevor Janes; Noel Angel Espinosa-Jalapa; David Milstein. J. Am. Chem. Soc. 2018, 140, 7453–7457. DOI: 10.1021/jacs.8b04581


193. Total Synthesis and Full Structural Assignment of Namenamicin

K. C. Nicolaou; Ruofan Li; Zhaoyong Lu; Emmanuel N. Pitsinos; Lawrence B. Alemany. J. Am. Chem. Soc. 2018, 140, 8091–8095. DOI: 10.1021/jacs.8b04592


194. Branch-Selective and Enantioselective Iridium-Catalyzed Alkene Hydroarylation via Anilide-Directed C–H Oxidative Addition

Simon Grélaud; Phillippa Cooper; Lyman J. Feron; John F. Bower. J. Am. Chem. Soc. 2018, 140, 9351–9356. DOI: 10.1021/jacs.8b04627


195. A Revised Mechanism for the Kinugasa Reaction

Thomas C. Malig; Diana Yu; Jason E. Hein. J. Am. Chem. Soc. 2018, 140, 9167–9173. DOI: 10.1021/jacs.8b04635


196. Synthesis of Tetrasubstituted Alkenes by Tandem Metallacycle Formation/Cross-Electrophile Coupling

Kirk W. Shimkin; John Montgomery. J. Am. Chem. Soc. 2018, 140, 7074–7078. DOI: 10.1021/jacs.8b04637


197. Highly Enantioselective Nickel-Catalyzed Intramolecular Hydroalkenylation of N- and O-Tethered 1,6-Dienes To Form Six-Membered Heterocycles

Ke Li; Mao-Lin Li; Qi Zhang; Shou-Fei Zhu; Qi-Lin Zhou. J. Am. Chem. Soc. 2018, 140, 7458–7461. DOI: 10.1021/jacs.8b04703


198. Enantioselective Synthesis of anti-1,2-Diamines by Cu-Catalyzed Reductive Couplings of Azadienes with Aldimines and Ketimines

Xinxin Shao; Kangnan Li; Steven J. Malcolmson. J. Am. Chem. Soc. 2018, 140, 7083–7087. DOI: 10.1021/jacs.8b04750


199. Integrating Organic Lewis Acid and Redox Catalysis: The Phenalenyl Cation in Dual Role

Jasimuddin Ahmed; Soumi Chakraborty; Anex Jose; Sreejyothi P; Swadhin K. Mandal. J. Am. Chem. Soc. 2018, 140, 8330–8339. DOI: 10.1021/jacs.8b04786


200. Isotope Effects Reveal an Alternative Mechanism for “Iminium-Ion” Catalysis

Joseph A. Izzo; Pernille H. Poulsen; Jeremy A. Intrator; Karl Anker Jørgensen; Mathew J. Vetticatt. J. Am. Chem. Soc. 2018, 140, 8396–8400. DOI: 10.1021/jacs.8b04856


201. Generation and Alkylation of α-Carbamyl Radicals via Organic Photoredox Catalysis

Joshua B. McManus; Nicholas P. R. Onuska; David A. Nicewicz. J. Am. Chem. Soc. 2018, 140, 9056–9060. DOI: 10.1021/jacs.8b04890


202. Divergent Synthesis of Pyrone Diterpenes via Radical Cross Coupling

Rohan R. Merchant; Kevin M. Oberg; Yutong Lin; Alexander J. E. Novak; Jakob Felding; Phil S. Baran. J. Am. Chem. Soc. 2018, 140, 7462–7465. DOI: 10.1021/jacs.8b04891


203. Enantioselective Copper-Catalyzed Defluoroalkylation Using Arylboronate-Activated Alkyl Grignard Reagents

Minyan Wang; Xinghui Pu; Yunfei Zhao; Panpan Wang; Zexian Li; Chendan Zhu; Zhuangzhi Shi. J. Am. Chem. Soc. 2018, 140, 9061–9065. DOI: 10.1021/jacs.8b04902


204. A Room-Temperature-Stable Phosphanorcaradiene

Liu Leo Liu; Jiliang Zhou; Ryan Andrews; Douglas W. Stephan. J. Am. Chem. Soc. 2018, 140, 7466–7470. DOI: 10.1021/jacs.8b04930


205. Enantioselective Synthesis of α-Amidoboronates Catalyzed by Planar-Chiral NHC-Cu(I) Complexes

C. Benjamin Schwamb; Keegan P. Fitzpatrick; Alexander C. Brueckner; H. Camille Richardson; Paul H.-Y. Cheong; Karl A. Scheidt. J. Am. Chem. Soc. 2018, 140, 10644–10648. DOI: 10.1021/jacs.8b05045


206. Carbon Dioxide-Mediated C(sp3)–H Arylation of Amine Substrates

Mohit Kapoor; Daniel Liu; Michael C. Young. J. Am. Chem. Soc. 2018, 140, 6818–6822. DOI: 10.1021/jacs.8b05061


207. Catalysis-Based Total Syntheses of Pateamine A and DMDA-Pat A

Chun-Xiang Zhuo; Alois Fürstner. J. Am. Chem. Soc. 2018, 140, 10514–10523. DOI: 10.1021/jacs.8b05094


208. Diastereodivergent Reductive Cross Coupling of Alkynes through Tandem Catalysis: Z- and E-Selective Hydroarylation of Terminal Alkynes

Megan K. Armstrong; Madison B. Goodstein; Gojko Lalic. J. Am. Chem. Soc. 2018, 140, 10233–10241. DOI: 10.1021/jacs.8b05113


209. Asymmetric Photocatalytic C–H Functionalization of Toluene and Derivatives

Daniele Mazzarella; Giacomo E. M. Crisenza; Paolo Melchiorre. J. Am. Chem. Soc. 2018, 140, 8439–8443. DOI: 10.1021/jacs.8b05240


210. Redox-Neutral Photocatalytic Cyclopropanation via Radical/Polar Crossover

James P. Phelan; Simon B. Lang; Jordan S. Compton; Christopher B. Kelly; Ryan Dykstra; Osvaldo Gutierrez; Gary A. Molander. J. Am. Chem. Soc. 2018, 140, 8037–8047. DOI: 10.1021/jacs.8b05243


211. Cu-Catalyzed Aerobic Oxidative N–N Coupling of Carbazoles and Diarylamines Including Selective Cross-Coupling

Michael C. Ryan; Joseph R. Martinelli; Shannon S. Stahl. J. Am. Chem. Soc. 2018, 140, 9074–9077. DOI: 10.1021/jacs.8b05245


212. Conformational Properties of a Peptidic Catalyst: Insights from NMR Spectroscopic Studies

Carla Rigling; Jessica K. Kisunzu; Jörg Duschmalé; Daniel Häussinger; Markus Wiesner; Marc-Olivier Ebert; Helma Wennemers. J. Am. Chem. Soc. 2018, 140, 10829–10838. DOI: 10.1021/jacs.8b05459


213. Dimethylcethrene: A Chiroptical Diradicaloid Photoswitch

Prince Ravat; Tomáš Šolomek; Daniel Häussinger; Olivier Blacque; Michal Juríček. J. Am. Chem. Soc. 2018, 140, 10839–10847. DOI: 10.1021/jacs.8b05465


214. Catalytic Enantioselective Synthesis of Acyclic Quaternary Centers: Palladium-Catalyzed Decarboxylative Allylic Alkylation of Fully Substituted Acyclic Enol Carbonates

Eric J. Alexy; Haiming Zhang; Brian M. Stoltz. J. Am. Chem. Soc. 2018, 140, 10109–10112. DOI: 10.1021/jacs.8b05560


215. Asymmetric Allylic C–H Alkylation via Palladium(II)/cis-ArSOX Catalysis

Wei Liu; Siraj Z. Ali; Stephen E. Ammann; M. Christina White. J. Am. Chem. Soc. 2018, 140, 10658–10662. DOI: 10.1021/jacs.8b05668


216. Enantioselective Ruthenium-Catalyzed Benzocyclobutenone–Ketol Cycloaddition: Merging C–C Bond Activation and Transfer Hydrogenative Coupling for Type II Polyketide Construction

Brett R. Ambler; Ben W. H. Turnbull; Sankar Rao Suravarapu; Maulen M. Uteuliyev; Nancy O. Huynh; Michael J. Krische. J. Am. Chem. Soc. 2018, 140, 9091–9094. DOI: 10.1021/jacs.8b05724


217. Cu-Catalyzed Enantioselective Ring Opening of Cyclic Diaryliodoniums toward the Synthesis of Chiral Diarylmethanes

Bin Li; Zengyin Chao; Chunyu Li; Zhenhua Gu. J. Am. Chem. Soc. 2018, 140, 9400–9403. DOI: 10.1021/jacs.8b05743


218. Epimerization of Tertiary Carbon Centers via Reversible Radical Cleavage of Unactivated C(sp3)–H Bonds

Yaxin Wang; Xiafei Hu; Cristian A. Morales-Rivera; Guo-Xing Li; Xin Huang; Gang He; Peng Liu; Gong Chen. J. Am. Chem. Soc. 2018, 140, 9678–9684. DOI: 10.1021/jacs.8b05753


219. Rearrangement of Hydroxylated Pinene Derivatives to Fenchone-Type Frameworks: Computational Evidence for Dynamically-Controlled Selectivity

Marcus Blümel; Shota Nagasawa; Katherine Blackford; Stephanie R. Hare; Dean J. Tantillo; Richmond Sarpong. J. Am. Chem. Soc. 2018, 140, 9291–9298. DOI: 10.1021/jacs.8b05804


220. Total Synthesis of (−)-Xishacorene B from (R)-Carvone Using a C–C Activation Strategy

Isabel Kerschgens; Alexander R. Rovira; Richmond Sarpong. J. Am. Chem. Soc. 2018, 140, 9810–9813. DOI: 10.1021/jacs.8b05832


221. Rhodium-Catalyzed B–H Bond Insertion Reactions of Unstabilized Diazo Compounds Generated in Situ from Tosylhydrazones

Yue Pang; Qiao He; Zi-Qi Li; Ji-Min Yang; Jin-Han Yu; Shou-Fei Zhu; Qi-Lin Zhou. J. Am. Chem. Soc. 2018, 140, 10663–10668. DOI: 10.1021/jacs.8b05946


222. Chiral Diaryliodonium Phosphate Enables Light Driven Diastereoselective α-C(sp3)–H Acetalization

Baihua Ye; Jie Zhao; Ke Zhao; Jeffrey M. McKenna; F. Dean Toste. J. Am. Chem. Soc. 2018, 140, 8350–8356. DOI: 10.1021/jacs.8b05962


223. Tandem Catalysis: Transforming Alcohols to Alkenes by Oxidative Dehydroxymethylation

Xuesong Wu; Faben A. Cruz; Alexander Lu; Vy M. Dong. J. Am. Chem. Soc. 2018, 140, 10126–10130. DOI: 10.1021/jacs.8b06069


224. Synthesis of Enantioenriched Bromohydrins via Divergent Reactions of Racemic Intermediates from Anchimeric Oxygen Borrowing

Yi-Ming Cao; Dieter Lentz; Mathias Christmann. J. Am. Chem. Soc. 2018, 140, 10677–10681. DOI: 10.1021/jacs.8b06432


225. Integrating Metal-Catalyzed C–H and C–O Functionalization To Achieve Sterically Controlled Regioselectivity in Arene Acylation

Nicholas A. Serratore; Constance B. Anderson; Grant B. Frost; Truong-Giang Hoang; Steven J. Underwood; Philipp M. Gemmel; Melissa A. Hardy; Christopher J. Douglas. J. Am. Chem. Soc. 2018, 140, 10025–10033. DOI: 10.1021/jacs.8b06476


226. Chiral Aldehyde Catalysis for the Catalytic Asymmetric Activation of Glycine Esters

Wei Wen; Lei Chen; Ming-Jing Luo; Yan Zhang; Ying-Chun Chen; Qin Ouyang; Qi-Xiang Guo. J. Am. Chem. Soc. 2018, 140, 9774–9780. DOI: 10.1021/jacs.8b06676


227. C–H Functionalization of Amines via Alkene-Derived Nucleophiles through Cooperative Action of Chiral and Achiral Lewis Acid Catalysts: Applications in Enantioselective Synthesis

Ming Shang; Jessica Z. Chan; Min Cao; Yejin Chang; Qifan Wang; Brennan Cook; Sebastian Torker; Masayuki Wasa. J. Am. Chem. Soc. 2018, 140, 10593–10601. DOI: 10.1021/jacs.8b06699


228. Completing a Charge Transport Chain for Artificial Photosynthesis

Michael S. Eberhart; Leah M. Rader Bowers; Bing Shan; Ludovic Troian-Gautier; M. Kyle Brennaman; John M. Papanikolas; Thomas J. Meyer. J. Am. Chem. Soc. 2018, 140, 9823–9826. DOI: 10.1021/jacs.8b06740


229. Intermolecular Carboamination of Unactivated Alkenes

Yu Zhang; Haidong Liu; Luning Tang; Hai-Jun Tang; Lu Wang; Chuan Zhu; Chao Feng. J. Am. Chem. Soc. 2018, 140, 10695–10699. DOI: 10.1021/jacs.8b07023


230. Chiral Cyclohexyl-Fused Spirobiindanes: Practical Synthesis, Ligand Development, and Asymmetric Catalysis

Zhiyao Zheng; Yuxi Cao; Qinglei Chong; Zhaobin Han; Jiaming Ding; Chenguang Luo; Zheng Wang; Dongsheng Zhu; Qi-Lin Zhou; Kuiling Ding. J. Am. Chem. Soc. 2018, 140, 10374–10381. DOI: 10.1021/jacs.8b07125


231. Photoinduced Deaminative Borylation of Alkylamines

Jingjing Wu; Lin He; Adam Noble; Varinder K. Aggarwal. J. Am. Chem. Soc. 2018, 140, 10700–10704. DOI: 10.1021/jacs.8b07103


232. Ligand-Controlled Regioselective Hydrocarboxylation of Styrenes with CO2 by Combining Visible Light and Nickel Catalysis

Qing-Yuan Meng; Shun Wang; Gregory S. Huff; Burkhard König. J. Am. Chem. Soc. 2018, 140, 3198–3201. DOI: 10.1021/jacs.7b13448


233. C–H to C–N Cross-Coupling of Sulfonamides with Olefins

Rulin Ma; M. Christina White. J. Am. Chem. Soc. 2018, 140, 3202–3205. DOI: 10.1021/jacs.7b13492


234. Highly Diastereoselective Palladium-Catalyzed Oxidative Carbocyclization of Enallenes Assisted by a Weakly Coordinating Hydroxyl Group

Daniels Posevins; Youai Qiu; Jan-E. Bäckvall. J. Am. Chem. Soc. 2018, 140, 3210–3214. DOI: 10.1021/jacs.7b13563


235. Enantioselective Intermolecular [2+2] Photocycloaddition Reaction of Cyclic Enones and Its Application in a Synthesis of (−)-Grandisol

Saner Poplata; Thorsten Bach. J. Am. Chem. Soc. 2018, 140, 3228–3231. DOI: 10.1021/jacs.8b01011


236. Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols

Eric D. Nacsa; David W. C. MacMillan. J. Am. Chem. Soc. 2018, 140, 3322–3330. DOI: 10.1021/jacs.7b12768


237. Enantioselective Synthesis of Pyrroloindolines via Noncovalent Stabilization of Indole Radical Cations and Applications to the Synthesis of Alkaloid Natural Products

Emily C. Gentry; Lydia J. Rono; Martina E. Hale; Rei Matsuura; Robert R. Knowles. J. Am. Chem. Soc. 2018, 140, 3394–3402. DOI: 10.1021/jacs.7b13616


238. Selective [1,4]-Hydrovinylation of 1,3-Dienes with Unactivated Olefins Enabled by Iron Diimine Catalysts

Valerie A. Schmidt; C. Rose Kennedy; Máté J. Bezdek; Paul J. Chirik. J. Am. Chem. Soc. 2018, 140, 3443–3453. DOI: 10.1021/jacs.8b00245


239. Palladium/PC-Phos-Catalyzed Enantioselective Arylation of General Sulfenate Anions: Scope and Synthetic Applications

Lei Wang; Mingjie Chen; Peichao Zhang; Wenbo Li; Junliang Zhang. J. Am. Chem. Soc. 2018, 140, 3467–3473. DOI: 10.1021/jacs.8b00178


240. Diastereo- and Enantioselective Formal [3 + 2] Cycloaddition of Cyclopropyl Ketones and Alkenes via Ti-Catalyzed Radical Redox Relay

Wei Hao; Johannes H. Harenberg; Xiangyu Wu; Samantha N. MacMillan; Song Lin. J. Am. Chem. Soc. 2018, 140, 3514–3517. DOI: 10.1021/jacs.7b13710


241. Asymmetric Induction via a Helically Chiral Anion: Enantioselective Pentacarboxycyclopentadiene Brønsted Acid-Catalyzed Inverse-Electron-Demand Diels–Alder Cycloaddition of Oxocarbenium Ions

Chirag D. Gheewala; Jennifer S. Hirschi; Wai-Hang Lee; Daniel W. Paley; Mathew J. Vetticatt; Tristan H. Lambert. J. Am. Chem. Soc. 2018, 140, 3523–3527. DOI: 10.1021/jacs.8b00260


242. Synthesis and Applications of Unquaternized C-Bound Boron Enolates

Elvis Wang Hei Ng; Kam-Hung Low; Pauline Chiu. J. Am. Chem. Soc. 2018, 140, 3537–3541. DOI: 10.1021/jacs.8b00614


243. Superbase-Catalyzed anti-Markovnikov Alcohol Addition Reactions to Aryl Alkenes

Chaosheng Luo; Jeffrey S. Bandar. J. Am. Chem. Soc. 2018, 140, 3547–3550. DOI: 10.1021/jacs.8b00766


244. Ligand-Enabled γ-C(sp3)–H Activation of Ketones

Ru-Yi Zhu; Zi-Qi Li; Han Seul Park; Chris H. Senanayake; Jin-Quan Yu. J. Am. Chem. Soc. 2018, 140, 3564–3568. DOI: 10.1021/jacs.8b01359


245. Enantioselective, Lewis Base-Catalyzed Sulfenocyclization of Polyenes

Zhonglin Tao; Kevin A. Robb; Kuo Zhao; Scott E. Denmark. J. Am. Chem. Soc. 2018, 140, 3569–3573. DOI: 10.1021/jacs.8b01660


246. Carbohydrate/DBU Cocatalyzed Alkene Diboration: Mechanistic Insight Provides Enhanced Catalytic Efficiency and Substrate Scope

Lu Yan; Yan Meng; Fredrik Haeffner; Robert M. Leon; Michael P. Crockett; James P. Morken. J. Am. Chem. Soc. 2018, 140, 3663–3673. DOI: 10.1021/jacs.7b12316


247. Catalytic Azoarene Synthesis from Aryl Azides Enabled by a Dinuclear Ni Complex

Ian G. Powers; John M. Andjaba; Xuyi Luo; Jianguo Mei; Christopher Uyeda. J. Am. Chem. Soc. 2018, 140, 4110–4118. DOI: 10.1021/jacs.8b00503


248. Cobalt(II)-Catalyzed Electrooxidative C–H Amination of Arenes with Alkylamines

Xinlong Gao; Pan Wang; Li Zeng; Shan Tang; Aiwen Lei. J. Am. Chem. Soc. 2018, 140, 4195–4199. DOI: 10.1021/jacs.7b13049


249. A General Strategy for Aliphatic C–H Functionalization Enabled by Organic Photoredox Catalysis

Kaila A. Margrey; William L. Czaplyski; David A. Nicewicz; Erik J. Alexanian. J. Am. Chem. Soc. 2018, 140, 4213–4217. DOI: 10.1021/jacs.8b00592


250. Dynamic Kinetic Asymmetric Heck Reaction for the Simultaneous Generation of Central and Axial Chirality

José A. Carmona; Valentín Hornillos; Pedro Ramírez-López; Abel Ros; Javier Iglesias-Sigüenza; Enrique Gómez-Bengoa; Rosario Fernández; José M. Lassaletta. J. Am. Chem. Soc. 2018, 140, 11067–11075. DOI: 10.1021/jacs.8b05819


251. How a Solvent Molecule Affects Competing Elimination and Substitution Dynamics. Insight into Mechanism Evolution with Increased Solvation

Xu Liu; Jiaxu Zhang; Li Yang; William L. Hase. J. Am. Chem. Soc. 2018, 140, 10995–11005. DOI: 10.1021/jacs.8b04529


252. Ring-Closing Synthesis of Dibenzothiophene Sulfonium Salts and Their Use as Leaving Groups for Aromatic 18F-Fluorination

Thibault Gendron; Kerstin Sander; Klaudia Cybulska; Laure Benhamou; Pak Kwan Brian Sin; Aqsa Khan; Michael Wood; Michael J. Porter; Erik Årstad. J. Am. Chem. Soc. 2018, 140, 11125–11132. DOI: 10.1021/jacs.8b06730


253. Enantioselective Trifluoromethylalkynylation of Alkenes via Copper-Catalyzed Radical Relay

Liang Fu; Song Zhou; Xiaolong Wan; Pinhong Chen; Guosheng Liu. J. Am. Chem. Soc. 2018, 140, 10965–10969. DOI: 10.1021/jacs.8b07436


254. Copper-Catalyzed Electrochemical C–H Amination of Arenes with Secondary Amines

Qi-Liang Yang; Xiang-Yang Wang; Jia-Yan Lu; Li-Pu Zhang; Ping Fang; Tian-Sheng Mei. J. Am. Chem. Soc. 2018, 140, 11487–11494. DOI: 10.1021/jacs.8b07380


255. Kinetics of Electrophilic Fluorinations of Enamines and Carbanions: Comparison of the Fluorinating Power of N–F Reagents

Daria S. Timofeeva; Armin R. Ofial; Herbert Mayr. J. Am. Chem. Soc. 2018, 140, 11474–11486. DOI: 10.1021/jacs.8b07147


256. Iron–Nickel Dual-Catalysis: A New Engine for Olefin Functionalization and the Formation of Quaternary Centers

Samantha A. Green; Suhelen Vásquez-Céspedes; Ryan A. Shenvi. J. Am. Chem. Soc. 2018, 140, 11317–11324. DOI: 10.1021/jacs.8b05868


257. Electrochemical Aminoxyl-Mediated α-Cyanation of Secondary Piperidines for Pharmaceutical Building Block Diversification

Alastair J. J. Lennox; Shannon L. Goes; Matthew P. Webster; Hannes F. Koolman; Stevan W. Djuric; Shannon S. Stahl. J. Am. Chem. Soc. 2018, 140, 11227–11231. DOI: 10.1021/jacs.8b08145


258. Catalytic Alkene Difunctionalization via Imidate Radicals

Kohki M. Nakafuku; Stacy C. Fosu; David A. Nagib. J. Am. Chem. Soc. 2018, 140, 11202–11205. DOI: 10.1021/jacs.8b07578


259. Ligand-Induced Reductive Elimination of Ethane from Azopyridine Palladium Dimethyl Complexes

Andrey E. Rudenko; Naomi E. Clayman; Katherine L. Walker; Jana K. Maclaren; Paul M. Zimmerman; Robert M. Waymouth. J. Am. Chem. Soc. 2018, 140, 11408–11415. DOI: 10.1021/jacs.8b06398


260. Asymmetric Synthesis of Cyclobutanone via Lewis Acid Catalyzed Tandem Cyclopropanation/Semipinacol Rearrangement

Su Yong Shim; Yuna Choi; Do Hyun Ryu. J. Am. Chem. Soc. 2018, 140, 11184–11188. DOI: 10.1021/jacs.8b06835


261. Benzoate Cyclometalation Enables Oxidative Addition of Haloarenes at a Ru(II) Center

Marco Simonetti; Rositha Kuniyil; Stuart A. Macgregor; Igor Larrosa. J. Am. Chem. Soc. 2018, 140, 11836–11847. DOI: 10.1021/jacs.8b08150


262. Divergent Entry to Gelsedine-Type Alkaloids: Total Syntheses of (−)-Gelsedilam, (−)-Gelsenicine, (−)-Gelsedine, and (−)-Gelsemoxonine

Pingluan Wang; Yang Gao; Dawei Ma. J. Am. Chem. Soc. 2018, 140, 11608–11612. DOI: 10.1021/jacs.8b08127


263. Iron-Mediated Coupling of Carbon Dioxide and Ethylene: Macrocyclic Metallalactones Enable Access to Various Carboxylates

Stephan M. Rummelt; Hongyu Zhong; Ilia Korobkov; Paul J. Chirik. J. Am. Chem. Soc. 2018, 140, 11589–11593. DOI: 10.1021/jacs.8b07558


264. Catalyst-Controlled Selective Functionalization of Unactivated C–H Bonds in the Presence of Electronically Activated C–H Bonds

Wenbin Liu; Zhi Ren; Aaron T. Bosse; Kuangbiao Liao; Elizabeth L. Goldstein; John Bacsa; Djamaladdin G. Musaev; Brian M. Stoltz; Huw M. L. Davies. J. Am. Chem. Soc. 2018, 140, 12247–12255. DOI: 10.1021/jacs.8b07534


265. Mechanistic Insight into Asymmetric Hetero-Michael Addition of α,β-Unsaturated Carboxylic Acids Catalyzed by Multifunctional Thioureas

Noboru Hayama; Ryuta Kuramoto; Tamás Földes; Kazuya Nishibayashi; Yusuke Kobayashi; Imre Pápai; Yoshiji Takemoto. J. Am. Chem. Soc. 2018, 140, 12216–12225. DOI: 10.1021/jacs.8b07511


266. sp3 C–H Arylation and Alkylation Enabled by the Synergy of Triplet Excited Ketones and Nickel Catalysts

Yangyang Shen; Yiting Gu; Ruben Martin. J. Am. Chem. Soc. 2018, 140, 12200–12209. DOI: 10.1021/jacs.8b07405


267. Mechanistic Interrogation of Co/Ni-Dual Catalyzed Hydroarylation

Sophia L. Shevick; Carla Obradors; Ryan A. Shenvi. J. Am. Chem. Soc. 2018, 140, 12056–12068. DOI: 10.1021/jacs.8b06458


268. Stereoselective Synthesis of Cyclohexanes via an Iridium Catalyzed (5 + 1) Annulation Strategy

Wasim M. Akhtar; Roly J. Armstrong; James R. Frost; Neil G. Stevenson; Timothy J. Donohoe. J. Am. Chem. Soc. 2018, 140, 11916–11920. DOI: 10.1021/jacs.8b07776


269. An Empirical Understanding of the Glycosylation Reaction

Sourav Chatterjee; Sooyeon Moon; Felix Hentschel; Kerry Gilmore; Peter H. Seeberger. J. Am. Chem. Soc. 2018, 140, 11942–11953. DOI: 10.1021/jacs.8b04525


270. Electrochemical Azidooxygenation of Alkenes Mediated by a TEMPO–N3 Charge-Transfer Complex

Juno C. Siu; Gregory S. Sauer; Ambarneil Saha; Reed L. Macey; Niankai Fu; Timothée Chauviré; Kyle M. Lancaster; Song Lin. J. Am. Chem. Soc. 2018, 140, 12511–12520. DOI: 10.1021/jacs.8b06744


271. Cation−π Interactions in the Benzylic Arylation of Toluenes with Bimetallic Catalysts

Sheng-Chun Sha; Sergei Tcyrulnikov; Minyan Li; Bowen Hu; Yue Fu; Marisa C. Kozlowski; Patrick J. Walsh. J. Am. Chem. Soc. 2018, 140, 12415–12423. DOI: 10.1021/jacs.8b05143


272. Intermolecular Radical Mediated Anti-Markovnikov Alkene Hydroamination Using N-Hydroxyphthalimide

Samuel W. Lardy; Valerie A. Schmidt. J. Am. Chem. Soc. 2018, 140, 12318–12322. DOI: 10.1021/jacs.8b06881


273. Ir(III)-Catalyzed Stereoselective Haloamidation of Alkynes Enabled by Ligand Participation

Seung Youn Hong; Junsoo Son; Dongwook Kim; Sukbok Chang. J. Am. Chem. Soc. 2018, 140, 12359–12363. DOI: 10.1021/jacs.8b08134


274. Exploration of Diverse Reactive Diad Geometries for Bifunctional Catalysis via Foldamer Backbone Variation

Zebediah C. Girvin; Samuel H. Gellman. J. Am. Chem. Soc. 2018, 140, 12476–12483. DOI: 10.1021/jacs.8b05869


275. Twelve-Step Asymmetric Synthesis of (−)-Nodulisporic Acid C

Nicole A. Godfrey; Devon J. Schatz; Sergey V. Pronin. J. Am. Chem. Soc. 2018, 140, 12770–12774. DOI: 10.1021/jacs.8b09965


276. Catalytic Cyclooligomerization of Enones with Three Methylene Equivalents

Conner M. Farley; You-Yun Zhou; Nishit Banka; Christopher Uyeda. J. Am. Chem. Soc. 2018, 140, 12710–12714. DOI: 10.1021/jacs.8b08296


277. Diastereoselective Allylation of Aldehydes by Dual Photoredox and Chromium Catalysis

J. Luca Schwarz; Felix Schäfers; Adrian Tlahuext-Aca; Lukas Lückemeier; Frank Glorius. J. Am. Chem. Soc. 2018, 140, 12705–12709. DOI: 10.1021/jacs.8b08052


278. Enantioselective Oxidative Coupling of Carboxylic Acids to α-Branched Aldehydes

Lars A. Leth; Line Næsborg; Gabriel J. Reyes-Rodríguez; Henriette N. Tobiesen; Marc V. Iversen; Karl Anker Jørgensen. J. Am. Chem. Soc. 2018, 140, 12687–12690. DOI: 10.1021/jacs.8b07394


279. Scalable and Highly Diastereo- and Enantioselective Catalytic Diels–Alder Reaction of α,β-Unsaturated Methyl Esters

Tim Gatzenmeier; Mathias Turberg; Diana Yepes; Youwei Xie; Frank Neese; Giovanni Bistoni; Benjamin List. J. Am. Chem. Soc. 2018, 140, 12671–12676. DOI: 10.1021/jacs.8b07092


280. Site-Selective Ni-Catalyzed Reductive Coupling of α-Haloboranes with Unactivated Olefins

Shang-Zheng Sun; Marino Börjesson; Raul Martin-Montero; Ruben Martin. J. Am. Chem. Soc. 2018, 140, 12765–12769. DOI: 10.1021/jacs.8b09425


281. Enhanced Electrophilicity of Heterobimetallic Bi–Rh Paddlewheel Carbene Complexes: A Combined Experimental, Spectroscopic, and Computational Study

Lee R. Collins; Maurice van Gastel; Frank Neese; Alois Fürstner. J. Am. Chem. Soc. 2018, 140, 13042–13055. DOI: 10.1021/jacs.8b08384


282. Mechanistically Guided Design of Ligands That Significantly Improve the Efficiency of CuH-Catalyzed Hydroamination Reactions

Andy A. Thomas; Klaus Speck; Ilia Kevlishvili; Zhaohong Lu; Peng Liu; Stephen L. Buchwald. J. Am. Chem. Soc. 2018, 140, 13976–13984. DOI: 10.1021/jacs.8b09565


283. Site-Selective Cross-Coupling of Remote Chlorides Enabled by Electrostatically Directed Palladium Catalysis

William A. Golding; Robert Pearce-Higgins; Robert J. Phipps. J. Am. Chem. Soc. 2018, 140, 13570–13574. DOI: 10.1021/jacs.8b08686


284. Origin of and a Solution for Uneven Efficiency by Cinchona Alkaloid-Derived, Pseudoenantiomeric Catalysts for Asymmetric Reactions

Bin Hu; Mark W. Bezpalko; Chao Fei; Diane A. Dickie; Bruce M. Foxman; Li Deng. J. Am. Chem. Soc. 2018, 140, 13913–13920. DOI: 10.1021/jacs.8b09010


285. New Hindered Amide Base for Aryne Insertion into Si–P, Si–S, Si–N, and C–C Bonds

Milad Mesgar; Justin Nguyen-Le; Olafs Daugulis. J. Am. Chem. Soc. 2018, 140, 13703–13710. DOI: 10.1021/jacs.8b07064


286. Discovery of a Photoinduced Dark Catalytic Cycle Using in Situ LED-NMR Spectroscopy

Dan Lehnherr; Yining Ji; Andrew J. Neel; Ryan D. Cohen; Andrew P. J. Brunskill; Junyu Yang; Mikhail Reibarkh. J. Am. Chem. Soc. 2018, 140, 13843–13853. DOI: 10.1021/jacs.8b08596


287. Direct C–C Bond Formation from Alkanes Using Ni-Photoredox Catalysis

Laura K. G. Ackerman; Jesus I. Martinez Alvarado; Abigail G. Doyle. J. Am. Chem. Soc. 2018, 140, 14059–14063. DOI: 10.1021/jacs.8b09191


288. Copper-Mediated Amination of Aryl C–H Bonds with the Direct Use of Aqueous Ammonia via a Disproportionation Pathway

Hyunwoo Kim; Joon Heo; Junho Kim; Mu-Hyun Baik; Sukbok Chang. J. Am. Chem. Soc. 2018, 140, 14350–14356. DOI: 10.1021/jacs.8b08826


289. General Strategy for Improving the Quantum Efficiency of Photoredox Hydroamidation Catalysis

Serge Ruccolo; Yangzhong Qin; Christoph Schnedermann; Daniel G. Nocera. J. Am. Chem. Soc. 2018, 140, 14926–14937. DOI: 10.1021/jacs.8b09109


290. Ti-Catalyzed Radical Alkylation of Secondary and Tertiary Alkyl Chlorides Using Michael Acceptors

Xiangyu Wu; Wei Hao; Ke-Yin Ye; Binyang Jiang; Gisselle Pombar; Zhidong Song; Song Lin. J. Am. Chem. Soc. 2018, 140, 14836–14843. DOI: 10.1021/jacs.8b08605


291. Rhodium-Catalyzed Enantioconvergent Isomerization of Homoallylic and Bishomoallylic Secondary Alcohols

Rui-Zhi Huang; Kai Kiat Lau; Zhaofeng Li; Tang-Lin Liu; Yu Zhao. J. Am. Chem. Soc. 2018, 140, 14647–14654. DOI: 10.1021/jacs.8b07007


292. A Redox-Switchable, Allosteric Coordination Complex

Ho Fung Cheng; Andrea I. d’Aquino; Joaquín Barroso-Flores; Chad A. Mirkin. J. Am. Chem. Soc. 2018, 140, 14590–14594. DOI: 10.1021/jacs.8b09321


293. Use of Cyclopropane as C1 Synthetic Unit by Directed Retro-Cyclopropanation with Ethylene Release

Sobi Asako; Takaaki Kobashi; Kazuhiko Takai. J. Am. Chem. Soc. 2018, 140, 15425–15429. DOI: 10.1021/jacs.8b09297


294. Evidence for a Single Electron Shift in a Lewis Acid–Base Reaction

Zhaowen Dong; Hanna H. Cramer; Marc Schmidtmann; Lucas A. Paul; Inke Siewert; Thomas Müller. J. Am. Chem. Soc. 2018, 140, 15419–15424. DOI: 10.1021/jacs.8b09214


295. Intermolecular Reductive C–N Cross Coupling of Nitroarenes and Boronic Acids by PIII/PV═O Catalysis

Trevor V. Nykaza; Julian C. Cooper; Gen Li; Nolwenn Mahieu; Antonio Ramirez; Michael R. Luzung; Alexander T. Radosevich. J. Am. Chem. Soc. 2018, 140, 15200–15205. DOI: 10.1021/jacs.8b10769


296. Diastereoselective and Enantioselective Conjunctive Cross-Coupling Enabled by Boron Ligand Design

Jesse A. Myhill; Christopher A. Wilhelmsen; Liang Zhang; James P. Morken. J. Am. Chem. Soc. 2018, 140, 15181–15185. DOI: 10.1021/jacs.8b09909


297. A Practical Electrophilic Nitrogen Source for the Synthesis of Chiral Primary Amines by Copper-Catalyzed Hydroamination

Sheng Guo; Jeffrey C. Yang; Stephen L. Buchwald. J. Am. Chem. Soc. 2018, 140, 15976–15984. DOI: 10.1021/jacs.8b10564


298. Allenoates in Enantioselective [2+2] Cycloadditions: From a Mechanistic Curiosity to a Stereospecific Transformation

Johannes. M. Wiest; Michael L. Conner; M. Kevin Brown. J. Am. Chem. Soc. 2018, 140, 15943–15949. DOI: 10.1021/jacs.8b10008


299. Catalytic Regio- and Enantioselective Haloazidation of Allylic Alcohols

Frederick J. Seidl; Chang Min; Jovan A. Lopez; Noah Z. Burns. J. Am. Chem. Soc. 2018, 140, 15646–15650. DOI: 10.1021/jacs.8b10799


300. Enantioselective, Lewis Base-Catalyzed Carbosulfenylation of Alkenylboronates by 1,2-Boronate Migration

Zhonglin Tao; Kevin A. Robb; Jesse L. Panger; Scott E. Denmark. J. Am. Chem. Soc. 2018, 140, 15621–15625. DOI: 10.1021/jacs.8b10288


301. BF3-Promoted, Carbene-like, C–H Insertion Reactions of Benzynes

Hang Shen; Xiao Xiao; Moriana K. Haj; Patrick H. Willoughby; Thomas R. Hoye. J. Am. Chem. Soc. 2018, 140, 15616–15620. DOI: 10.1021/jacs.8b10206


302. Synthesis of Myrocin G, the Putative Active Form of the Myrocin Antitumor Antibiotics

Christos Economou; Martin Tomanik; Seth B. Herzon. J. Am. Chem. Soc. 2018, 140, 16058–16061. DOI: 10.1021/jacs.8b10891


303. Late-Stage Aromatic C–H Oxygenation

Jonas Börgel; Lalita Tanwar; Florian Berger; Tobias Ritter. J. Am. Chem. Soc. 2018, 140, 16026–16031. DOI: 10.1021/jacs.8b09208


304. SN2″-Selective and Enantioselective Substitution with Unsaturated Organoboron Compounds and Catalyzed by a Sulfonate-Containing NHC-Cu Complex

Yuebiao Zhou; Ying Shi; Sebastian Torker; Amir H. Hoveyda. J. Am. Chem. Soc. 2018, 140, 16842–16854. DOI: 10.1021/jacs.8b10885


305. Enantioselective Coupling of Dienes and Phosphine Oxides

Shao-Zhen Nie; Ryan T. Davison; Vy M. Dong. J. Am. Chem. Soc. 2018, 140, 16450–16454. DOI: 10.1021/jacs.8b11150


306. Total Synthesis of (−)-Mitrephorone A

Matthieu J. R. Richter; Michael Schneider; Marco Brandstätter; Simon Krautwald; Erick M. Carreira. J. Am. Chem. Soc. 2018, 140, 16704–16710. DOI: 10.1021/jacs.8b09685


307. Catalytic Radical–Polar Crossover Reactions of Allylic Alcohols

Eric E. Touney; Nicholas J. Foy; Sergey V. Pronin. J. Am. Chem. Soc. 2018, 140, 16982–16987. DOI: 10.1021/jacs.8b12075


308. Branch-Selective Addition of Unactivated Olefins into Imines and Aldehydes

Jeishla L. M. Matos; Suhelen Vásquez-Céspedes; Jieyu Gu; Takuya Oguma; Ryan A. Shenvi. J. Am. Chem. Soc. 2018, 140, 16976–16981. DOI: 10.1021/jacs.8b11699


309. Enantioselective Conversion of Oligoprenol Derivatives to Macrocycles in the Germacrene, Cembrene, and 18-Membered Cyclic Sesterterpene Series

D. Srinivas Reddy; E. J. Corey. J. Am. Chem. Soc. 2018, 140, 16909–16913. DOI: 10.1021/jacs.8b10522


310. Enantioselective Construction of Vicinal Diaxial Styrenes and Multiaxis System via Organocatalysis

Yu Tan; Shiqi Jia; Fangli Hu; Yidong Liu; Lei Peng; Dongmei Li; Hailong Yan. J. Am. Chem. Soc. 2018, 140, 16893–16898. DOI: 10.1021/jacs.8b09893


311. Enantioselective Allylic Alkylation with 4-Alkyl-1,4-dihydro-pyridines Enabled by Photoredox/Palladium Cocatalysis

Hong-Hao Zhang; Jia-Jia Zhao; Shouyun Yu. J. Am. Chem. Soc. 2018, 140, 16914–16919. DOI: 10.1021/jacs.8b10766


312. Central-to-Helical-to-Axial-to-Central Transfer of Chirality with a Photoresponsive Catalyst

Stefano F. Pizzolato; Peter Štacko; Jos C. M. Kistemaker; Thomas van Leeuwen; Edwin Otten; Ben L. Feringa. J. Am. Chem. Soc. 2018, 140, 17278–17289. DOI: 10.1021/jacs.8b10816


313. Metallaphotoredox-Catalyzed Cross-Electrophile Csp3–Csp3 Coupling of Aliphatic Bromides

Russell T. Smith; Xiaheng Zhang; Juan A. Rincón; Javier Agejas; Carlos Mateos; Mario Barberis; Susana García-Cerrada; Oscar de Frutos; David W. C. MacMillan. J. Am. Chem. Soc. 2018, 140, 17433–17438. DOI: 10.1021/jacs.8b12025


314. Direct Catalytic Enantioselective Benzylation from Aryl Acetic Acids

Patrick J. Moon; Zhongyu Wei; Rylan J. Lundgren. J. Am. Chem. Soc. 2018, 140, 17418–17422. DOI: 10.1021/jacs.8b11390


315. Visible-Light-Driven External-Reductant-Free Cross-Electrophile Couplings of Tetraalkyl Ammonium Salts

Li-Li Liao; Guang-Mei Cao; Jian-Heng Ye; Guo-Quan Sun; Wen-Jun Zhou; Yong-Yuan Gui; Si-Shun Yan; Guo Shen; Da-Gang Yu. J. Am. Chem. Soc. 2018, 140, 17338–17342. DOI: 10.1021/jacs.8b08792


316. Iridium-Catalyzed, β-Selective C(sp3)–H Silylation of Aliphatic Amines To Form Silapyrrolidines and 1,2-Amino Alcohols

Bo Su; Taegyo Lee; John F. Hartwig. J. Am. Chem. Soc. 2018, 140, 18032–18038. DOI: 10.1021/jacs.8b10428


317. Primary Anion−π Catalysis and Autocatalysis

Xiang Zhang; Xiaoyu Hao; Le Liu; Anh-Tuan Pham; Javier López-Andarias; Antonio Frontera; Naomi Sakai; Stefan Matile. J. Am. Chem. Soc. 2018, 140, 17867–17871. DOI: 10.1021/jacs.8b11788


318. Total Enzyme Syntheses of Napyradiomycins A1 and B1

Shaun M. K. McKinnie; Zachary D. Miles; Peter A. Jordan; Takayoshi Awakawa; Henry P. Pepper; Lauren A. M. Murray; Jonathan H. George; Bradley S. Moore. J. Am. Chem. Soc. 2018, 140, 17840–17845. DOI: 10.1021/jacs.8b10134


319. Nickel-Catalyzed 1,2-Diarylation of Simple Alkenyl Amides

Joseph Derosa; Roman Kleinmans; Van T. Tran; Malkanthi K. Karunananda; Steven R. Wisniewski; Martin D. Eastgate; Keary M. Engle. J. Am. Chem. Soc. 2018, 140, 17878–17883. DOI: 10.1021/jacs.8b11942


320. Chemoenzymatic Synthesis of Substituted Azepanes by Sequential Biocatalytic Reduction and Organolithium-Mediated Rearrangement

Wojciech Zawodny; Sarah L. Montgomery; James R. Marshall; James D. Finnigan; Nicholas J. Turner; Jonathan Clayden. J. Am. Chem. Soc. 2018, 140, 17872–17877. DOI: 10.1021/jacs.8b11891


321. Ambimodal Dipolar/Diels–Alder Cycloaddition Transition States Involving Proton Transfers

Shuming Chen; Peiyuan Yu; K. N. Houk. J. Am. Chem. Soc. 2018, 140, 18124–18131. DOI: 10.1021/jacs.8b11080


Angew. Chem. Int. Ed.


322. Inducing Axial Chirality in a Supramolecular Catalyst

Katharina Marie Wenz; Günter Leonhardt‐Lutterbeck; Bernhard Breit. Angew. Chem. Int. Ed. 2018, 57, 5100–5104. DOI: 10.1002/anie.201801048


323. Entropy‐Driven Diastereoselectivity Improvement in the Paternò–Büchi Reaction of 1‐Naphthyl Aryl Ethenes with a Chiral Cyanobenzoate through Remote Alkylation

Keisuke Nagasaki; Yoshihisa Inoue; Tadashi Mori. Angew. Chem. Int. Ed. 2018, 57, 4880–4885. DOI: 10.1002/anie.201801330


324. Intermolecular C(sp3)−H Amination of Complex Molecules

Nicholas D. Chiappini; James B. C. Mack; J. Du Bois. Angew. Chem. Int. Ed. 2018, 57, 4956–4959. DOI: 10.1002/anie.201713225


325. Electrochemical C−H Amination by Cobalt Catalysis in a Renewable Solvent

Nicolas Sauermann; Ruhuai Mei; Lutz Ackermann. Angew. Chem. Int. Ed. 2018, 57, 5090–5094. DOI: 10.1002/anie.201802206


326. Selective Hydrogen Atom Abstraction through Induced Bond Polarization: Direct α‐Arylation of Alcohols through Photoredox, HAT, and Nickel Catalysis

Jack Twilton; Melodie Christensen; Daniel A. DiRocco; Rebecca T. Ruck; Ian W. Davies; David W. C. MacMillan. Angew. Chem. Int. Ed. 2018, 57, 5369–5373. DOI: 10.1002/anie.201800749


327. Catalysis with Pnictogen, Chalcogen, and Halogen Bonds

Sebastian Benz; Amalia I. Poblador‐Bahamonde; Nicolas Low‐Ders; Stefan Matile. Angew. Chem. Int. Ed. 2018, 57, 5408–5412. DOI: 10.1002/anie.201801452


328. Mild Friedel–Crafts Reactions inside a Hexameric Resorcinarene Capsule: C−Cl Bond Activation through Hydrogen Bonding to Bridging Water Molecules

Pellegrino La Manna; Carmen Talotta; Giuseppe Floresta; Margherita De Rosa; Annunziata Soriente; Antonio Rescifina; Carmine Gaeta; Placido Neri. Angew. Chem. Int. Ed. 2018, 57, 5423–5428. DOI: 10.1002/anie.201801642


329. Asymmetric [3+2] Photocycloadditions of Cyclopropanes with Alkenes or Alkynes through Visible‐Light Excitation of Catalyst‐Bound Substrates

Xiaoqiang Huang; Jiahui Lin; Tianqi Shen; Klaus Harms; Marianna Marchini; Paola Ceroni; Eric Meggers. Angew. Chem. Int. Ed. 2018, 57, 5454–5458. DOI: 10.1002/anie.201802316


330. Site‐ and Enantioselective C−H Oxygenation Catalyzed by a Chiral Manganese Porphyrin Complex with a Remote Binding Site

Finn Burg; Maxime Gicquel; Stefan Breitenlechner; Alexander Pöthig; Thorsten Bach. Angew. Chem. Int. Ed. 2018, 57, 2953–2957. DOI: 10.1002/anie.201712340


331. Contra‐Thermodynamic, Photocatalytic E→Z Isomerization of Styrenyl Boron Species: Vectors to Facilitate Exploration of Two‐Dimensional Chemical Space

John J. Molloy; Jan B. Metternich; Constantin G. Daniliuc; Allan J. B. Watson; Ryan Gilmour. Angew. Chem. Int. Ed. 2018, 57, 3168–3172. DOI: 10.1002/anie.201800286


332. A C=O⋅⋅⋅Isothiouronium Interaction Dictates Enantiodiscrimination in Acylative Kinetic Resolutions of Tertiary Heterocyclic Alcohols

Mark D. Greenhalgh; Samuel M. Smith; Daniel M. Walden; James E. Taylor; Zamira Brice; Emily R. T. Robinson; Charlene Fallan; David B. Cordes; Alexandra M. Z. Slawin; H. Camille Richardson; Markas A. Grove; Paul Ha‐Yeon Cheong; Andrew D. Smith. Angew. Chem. Int. Ed. 2018, 57, 3200–3206. DOI: 10.1002/anie.201712456


333. Halogen Bond Catalyzed Bromocarbocyclization

Yuk‐Cheung Chan; Ying‐Yeung Yeung. Angew. Chem. Int. Ed. 2018, 57, 3483–3487. DOI: 10.1002/anie.201800261


334. Direct N‐Glycofunctionalization of Amides with Glycosyl Trichloroacetimidate by Thiourea/Halogen Bond Donor Co‐Catalysis

Yusuke Kobayashi; Yuya Nakatsuji; Shanji Li; Seiji Tsuzuki; Yoshiji Takemoto. Angew. Chem. Int. Ed. 2018, 57, 3646–3650. DOI: 10.1002/anie.201712726


335. Counterion‐Induced Asymmetric Control in Ring‐Opening of Azetidiniums: Facile Access to Chiral Amines

Deyun Qian; Min Chen; Alex C. Bissember; Jianwei Sun. Angew. Chem. Int. Ed. 2018, 57, 3763–3766. DOI: 10.1002/anie.201712395


336. Iodine(III) Derivatives as Halogen Bonding Organocatalysts

Flemming Heinen; Elric Engelage; Alexander Dreger; Robert Weiss; Stefan M. Huber. Angew. Chem. Int. Ed. 2018, 57, 3830–3833. DOI: 10.1002/anie.201713012


337. Direct Palladium‐Catalyzed β‐Arylation of Lactams

Ming Chen; Feipeng Liu; Guangbin Dong. Angew. Chem. Int. Ed. 2018, 57, 3815–3819. DOI: 10.1002/anie.201800958


338. Nickel(0)‐Catalyzed Hydroalkenylation of Imines with Styrene and Its Derivatives

Li‐Jun Xiao; Chao‐Yue Zhao; Lei Cheng; Bo‐Ya Feng; Wei‐Min Feng; Jian‐Hua Xie; Xiu‐Fang Xu; Qi‐Lin Zhou. Angew. Chem. Int. Ed. 2018, 57, 3396–3400. DOI: 10.1002/anie.201713333


339. Catalytic and Atom‐Economic C −C Bond Formation: Alkyl Tantalum Ureates for Hydroaminoalkylation

Rebecca C. DiPucchio; Sorin‐Claudiu Roşca; Laurel L. Schafer. Angew. Chem. Int. Ed. 2018, 57, 3469–3472. DOI: 10.1002/anie.201712668


340. Regioselective Cyclotrimerization of Terminal Alkynes Using a Digermyne

Tomohiro Sugahara; Jing‐Dong Guo; Takahiro Sasamori; Shigeru Nagase; Norihiro Tokitoh. Angew. Chem. Int. Ed. 2018, 57, 3499–3503. DOI: 10.1002/anie.201801222


341. Selective Reductive Elimination at Alkyl Palladium(IV) by Dissociative Ligand Ionization: Catalytic C(sp3)−H Amination to Azetidines

Manuel Nappi; Chuan He; William G. Whitehurst; Ben G. N. Chappell; Matthew J. Gaunt. Angew. Chem. Int. Ed. 2018, 57, 3178–3182. DOI: 10.1002/anie.201800519


342. Rhodium(I)‐Catalyzed Carboacylation/Aromatization Cascade Initiated by Regioselective C−C Activation of Benzocyclobutenones

Tianwen Sun; Yuna Zhang; Bo Qiu; Yafei Wang; Yuting Qin; Guangbin Dong; Tao Xu. Angew. Chem. Int. Ed. 2018, 57, 2859–2863. DOI: 10.1002/anie.201713179


343. (NHC)NiH‐Catalyzed Regiodivergent Cross‐Hydroalkenylation of Vinyl Ethers with α‐Olefins: Syntheses of 1,2‐ and 1,3‐Disubstituted Allyl Ethers

Weihao Chen; Yang Li; Yang Chen; Chun‐Yu Ho. Angew. Chem. Int. Ed. 2018, 57, 2677–2681. DOI: 10.1002/anie.201712693


344. Reductive Carbocyclization of Homoallylic Alcohols to syn‐Cyclobutanes by a Boron‐Catalyzed Dual Ring‐Closing Pathway

Chinmoy Kumar Hazra; Jinhoon Jeong; Hyunjoong Kim; Mu‐Hyun Baik; Sehoon Park; Sukbok Chang. Angew. Chem. Int. Ed. 2018, 57, 2692–2696. DOI: 10.1002/anie.201713285


345. Palladium‐Catalyzed Atom‐Transfer Radical Cyclization at Remote Unactivated C(sp3)−H Sites: Hydrogen‐Atom Transfer of Hybrid Vinyl Palladium Radical Intermediates

Maxim Ratushnyy; Marvin Parasram; Yang Wang; Vladimir Gevorgyan. Angew. Chem. Int. Ed. 2018, 57, 2712–2715. DOI: 10.1002/anie.201712775


346. Design, Synthesis, and Application of Chiral C2‐Symmetric Spiroketal‐Containing Ligands in Transition‐Metal Catalysis

Alonso J. Argüelles; Siyuan Sun; Brenna G. Budaitis; Pavel Nagorny. Angew. Chem. Int. Ed. 2018, 57, 5325–5329. DOI: 10.1002/anie.201713304


347. 2‐Hydroxybenzophenone as a Chemical Auxiliary for the Activation of Ketiminoesters for Highly Enantioselective Addition to Nitroalkenes under Bifunctional Catalysis

Andrea Guerrero‐Corella; Francisco Esteban; Manuel Iniesta; Ana Martín‐Somer; Mario Parra; Sergio Díaz‐Tendero; Alberto Fraile; Jose Alemán. Angew. Chem. Int. Ed. 2018, 57, 5350–5354. DOI: 10.1002/anie.201800435


348. Selective Hydrogen Atom Abstraction through Induced Bond Polarization: Direct α‐Arylation of Alcohols through Photoredox, HAT, and Nickel Catalysis

Jack Twilton; Melodie Christensen; Daniel A. DiRocco; Rebecca T. Ruck; Ian W. Davies; David W. C. MacMillan. Angew. Chem. Int. Ed. 2018, 57, 5369–5373. DOI: 10.1002/anie.201800749


349. Electrochemical Hydroxylation of Arenes Catalyzed by a Keggin Polyoxometalate with a Cobalt(IV) Heteroatom

Alexander M. Khenkin; Miriam Somekh; Raanan Carmieli; Ronny Neumann. Angew. Chem. Int. Ed. 2018, 57, 5403–5407. DOI: 10.1002/anie.201801372


350. Catalysis with Pnictogen, Chalcogen, and Halogen Bonds

Sebastian Benz; Amalia I. Poblador‐Bahamonde; Nicolas Low‐Ders; Stefan Matile. Angew. Chem. Int. Ed. 2018, 57, 5408–5412. DOI: 10.1002/anie.201801452


351. Asymmetric [3+2] Photocycloadditions of Cyclopropanes with Alkenes or Alkynes through Visible‐Light Excitation of Catalyst‐Bound Substrates

Xiaoqiang Huang; Jiahui Lin; Tianqi Shen; Klaus Harms; Marianna Marchini; Paola Ceroni; Eric Meggers. Angew. Chem. Int. Ed. 2018, 57, 5454–5458. DOI: 10.1002/anie.201802316


352. Photoinduced Copper‐Catalyzed Coupling of Terminal Alkynes and Alkyl Iodides

Avijit Hazra; Mitchell T. Lee; Justin F. Chiu; Gojko Lalic. Angew. Chem. Int. Ed. 2018, 57, 5492–5496. DOI: 10.1002/anie.201801085


353. Electrochemical Aziridination by Alkene Activation Using a Sulfamate as the Nitrogen Source

Jin Li; Wenhao Huang; Jingzhi Chen; Lingfeng He; Xu Cheng; Guigen Li. Angew. Chem. Int. Ed. 2018, 57, 5695–5698. DOI: 10.1002/anie.201801106


354. Transition‐Metal‐Free Decarboxylative Propargylic Substitution/Cyclization with either Azolium Enolates or Acyl Anions

Shenci Lu; Jun‐Yang Ong; Si Bei Poh; Terence Tsang; Yu Zhao. Angew. Chem. Int. Ed. 2018, 57, 5714–5719. DOI: 10.1002/anie.201801340


355. Bimetallic Chromium Catalysts with Chain Transfer Agents: A Route to Isotactic Poly(propylene oxide)s with Narrow Dispersities

Lilliana S. Morris; M. Ian Childers; Geoffrey W. Coates. Angew. Chem. Int. Ed. 2018, 57, 5731–5734. DOI: 10.1002/anie.201801380


356. Nickel Fluorocarbene Metathesis with Fluoroalkenes

Daniel J. Harrison; Alex L. Daniels; Jia Guan; Bulat M. Gabidullin; Michael B. Hall; R. Tom Baker. Angew. Chem. Int. Ed. 2018, 57, 5772–5776. DOI: 10.1002/anie.201802090


357. Electrooxidative Ruthenium‐Catalyzed C−H/O−H Annulation by Weak O‐Coordination

Youai Qiu; Cong Tian; Leonardo Massignan; Torben Rogge; Lutz Ackermann. Angew. Chem. Int. Ed. 2018, 57, 5818–5822. DOI: 10.1002/anie.201802748


358. Electrooxidative Rhodium‐Catalyzed C−H/C−H Activation: Electricity as Oxidant for Cross‐Dehydrogenative Alkenylation

Youai Qiu; Wei‐Jun Kong; Julia Struwe; Nicolas Sauermann; Torben Rogge; Alexej Scheremetjew; Lutz Ackermann. Angew. Chem. Int. Ed. 2018, 57, 5828–5832. DOI: 10.1002/anie.201803342


359. Site‐Selective δ‐C(sp3)−H Alkylation of Amino Acids and Peptides with Maleimides via a Six‐Membered Palladacycle

Bei‐Bei Zhan; Ya Li; Jing‐Wen Xu; Xing‐Liang Nie; Jun Fan; Liang Jin; Bing‐Feng Shi. Angew. Chem. Int. Ed. 2018, 57, 5858–5862. DOI: 10.1002/anie.201801445


360. Sulfoximidations of Benzylic C−H bonds by Photocatalysis

Han Wang; Duo Zhang; Carsten Bolm. Angew. Chem. Int. Ed. 2018, 57, 5863–5866. DOI: 10.1002/anie.201801660


361. Accessing Frustrated Lewis Pair Chemistry from a Spectroscopically Stable and Classical Lewis Acid‐Base Adduct

Timothy C. Johnstone; Gabriel N. J. H. Wee; Douglas W. Stephan. Angew. Chem. Int. Ed. 2018, 57, 5881–5884. DOI: 10.1002/anie.201802385


362. Stereoselective Synthesis of 2‐Deoxyglycosides from Glycals by Visible‐Light‐Induced Photoacid Catalysis

Gaoyuan Zhao; Ting Wang. Angew. Chem. Int. Ed. 2018, 57, 6120–6124. DOI: 10.1002/anie.201800909


363. Selective Monomethylation of Amines with Methanol as the C1 Source

Geunho Choi; Soon Hyeok Hong. Angew. Chem. Int. Ed. 2018, 57, 6166–6170. DOI: 10.1002/anie.201801524


364. Alkyl Ethers as Traceless Hydride Donors in Brønsted Acid Catalyzed Intramolecular Hydrogen Atom Transfer

Dhika Aditya Gandamana; Bin Wang; Ciputra Tejo; Benoit Bolte; Fabien Gagosz; Shunsuke Chiba. Angew. Chem. Int. Ed. 2018, 57, 6181–6185. DOI: 10.1002/anie.201801953


365. Catalytic Asymmetric Dearomatization by Visible‐Light‐Activated [2+2] Photocycloaddition

Naifu Hu; Hoimin Jung; Yu Zheng; Juhyeong Lee; Lilu Zhang; Zakir Ullah; Xiulan Xie; Klaus Harms; Mu‐Hyun Baik; Eric Meggers. Angew. Chem. Int. Ed. 2018, 57, 6242–6246. DOI: 10.1002/anie.201802891


366. Divergent Control of Point and Axial Stereogenicity: Catalytic Enantioselective C−N Bond‐Forming Cross‐Coupling and Catalyst‐Controlled Atroposelective Cyclodehydration

Yongseok Kwon; Alex J. Chinn; Byoungmoo Kim; Scott J. Miller. Angew. Chem. Int. Ed. 2018, 57, 6251–6255. DOI: 10.1002/anie.201802963


367. Palladium‐Catalyzed para‐Selective Alkylation of Electron‐Deficient Arenes

Zhiwei Jiao; Li Hui Lim; Hajime Hirao; Jianrong Steve Zhou. Angew. Chem. Int. Ed. 2018, 57, 6294–6298. DOI: 10.1002/anie.201801967


368. Catalytic Dinitrogen Reduction to Ammonia at a Triamidoamine–Titanium Complex

Laurence R. Doyle; Ashley J. Wooles; Lucy C. Jenkins; Floriana Tuna; Eric J. L. McInnes; Stephen T. Liddle. Angew. Chem. Int. Ed. 2018, 57, 6314–6318. DOI: 10.1002/anie.201802576


369. Organocatalytic Atroposelective Intramolecular [4+2] Cycloaddition: Synthesis of Axially Chiral Heterobiaryls

Yidong Liu; Xiaoyan Wu; Shan Li; Lu Xue; Chunhui Shan; Zhengxing Zhao; Hailong Yan. Angew. Chem. Int. Ed. 2018, 57, 6491–6495. DOI: 10.1002/anie.201801824


370. The N‐Methylpyrrolidone (NMP) Effect in Iron‐Catalyzed Cross‐Coupling with Simple Ferric Salts and MeMgBr

Salvador B. Muñoz; Stephanie L. Daifuku; Jeffrey D. Sears; Tessa M. Baker; Stephanie H. Carpenter; William W. Brennessel; Michael L. Neidig. Angew. Chem. Int. Ed. 2018, 57, 6496–6500. DOI: 10.1002/anie.201802087


371. Enantioselective Synthesis of Medium‐Sized Lactams via Chiral α,β‐Unsaturated Acylammonium Salts

Guowei Kang; Masaki Yamagami; Sreekumar Vellalath; Daniel Romo. Angew. Chem. Int. Ed. 2018, 57, 6527–6531. DOI: 10.1002/anie.201802483


372. Synthesis of Reversed C‐Acyl Glycosides through Ni/Photoredox Dual Catalysis

Shorouk O. Badir; Audrey Dumoulin; Jennifer K. Matsui; Gary A. Molander. Angew. Chem. Int. Ed. 2018, 57, 6610–6613. DOI: 10.1002/anie.201800701


373. Synthesis of Non‐Classical Arylated C‐Saccharides through Nickel/Photoredox Dual Catalysis

Audrey Dumoulin; Jennifer K. Matsui; Álvaro Gutiérrez‐Bonet; Gary A. Molander. Angew. Chem. Int. Ed. 2018, 57, 6614–6618. DOI: 10.1002/anie.201802282


374. Reactions of Fluoroalkenes with an Aluminium(I) Complex

Clare Bakewell; Andrew J. P. White; Mark R. Crimmin. Angew. Chem. Int. Ed. 2018, 57, 6638–6642. DOI: 10.1002/anie.201802321


375. Design of Trifluoroalkenyl Iodonium Salts for a Hypervalency‐Aided Alkenylation–Cyclization Strategy: Metal‐Free Construction of Aziridine Rings

Ádám Mészáros; Anna Székely; András Stirling; Zoltán Novák. Angew. Chem. Int. Ed. 2018, 57, 6643–6647. DOI: 10.1002/anie.201802347


376. A Desulfurative Strategy for the Generation of Alkyl Radicals Enabled by Visible‐Light Photoredox Catalysis

Fei Xue; Falu Wang; Jiazhen Liu; Jiamei Di; Qi Liao; Huifang Lu; Min Zhu; Liping He; Huan He; Dan Zhang; Hao Song; Xiao‐Yu Liu; Yong Qin. Angew. Chem. Int. Ed. 2018, 57, 6667–6671. DOI: 10.1002/anie.201802710


377. CuH‐Catalyzed Asymmetric Hydroamidation of Vinylarenes

Yujing Zhou; Oliver D. Engl; Jeffrey S. Bandar; Emma D. Chant; Stephen L. Buchwald. Angew. Chem. Int. Ed. 2018, 57, 6672–6675. DOI: 10.1002/anie.201802797


378. Electrochemical Functional‐Group‐Tolerant Shono‐type Oxidation of Cyclic Carbamates Enabled by Aminoxyl Mediators

Fei Wang; Mohammad Rafiee; Shannon S. Stahl. Angew. Chem. Int. Ed. 2018, 57, 6686–6690. DOI: 10.1002/anie.201803539


379. A General, Activator‐Free Palladium‐Catalyzed Synthesis of Arylacetic and Benzoic Acids from Formic Acid

Lin Wang; Helfried Neumann; Matthias Beller. Angew. Chem. Int. Ed. 2018, 57, 6910–6914. DOI: 10.1002/anie.201802384


380. Bulky Diamine Ligand Promotes Cross‐Coupling of Difluoroalkyl Bromides by Iron Catalysis

Lun An; Yu‐Lan Xiao; Shu Zhang; Xingang Zhang. Angew. Chem. Int. Ed. 2018, 57, 6921–6925. DOI: 10.1002/anie.201802713


381. Trifluoromethanesulfonic Anhydride as a Low‐Cost and Versatile Trifluoromethylation Reagent

Yao Ouyang; Xiu‐Hua Xu; Feng‐Ling Qing. Angew. Chem. Int. Ed. 2018, 57, 6926–6929. DOI: 10.1002/anie.201803566


382. Iron‐Catalyzed Ring‐Closing C−O/C−O Metathesis of Aliphatic Ethers

Tobias Biberger; Szabolcs Makai; Zhong Lian; Bill Morandi. Angew. Chem. Int. Ed. 2018, 57, 6940–6944. DOI: 10.1002/anie.201802563


383. Stereoretentive Reactions at the Anomeric Position: Synthesis of Selenoglycosides

Feng Zhu; Sloane O'Neill; Jacob Rodriguez; Maciej A. Walczak. Angew. Chem. Int. Ed. 2018, 57, 7091–7095. DOI: 10.1002/anie.201802847


384. Divergent Synthesis of CF3‐Substituted Allenyl Nitriles by Ligand‐Controlled Radical 1,2‐ and 1,4‐Addition to 1,3‐Enynes

Fei Wang; Dinghai Wang; Yu Zhou; Ling Liang; Ronghua Lu; Pinhong Chen; Zhenyang Lin; Guosheng Liu. Angew. Chem. Int. Ed. 2018, 57, 7140–7145. DOI: 10.1002/anie.201803668


385. The Discovery of a Palladium(II)‐Initiated Borono‐Catellani Reaction

Shuqing Chen; Ze‐Shui Liu; Tao Yang; Yu Hua; Zhiyu Zhou; Hong‐Gang Cheng; Qianghui Zhou. Angew. Chem. Int. Ed. 2018, 57, 7161–7165. DOI: 10.1002/anie.201803865


386. Electron‐Catalyzed Cross‐Coupling of Arylboron Compounds with Aryl Iodides

Keisho Okura; Tsuyoshi Teranishi; Yuto Yoshida; Eiji Shirakawa. Angew. Chem. Int. Ed. 2018, 57, 7186–7190. DOI: 10.1002/anie.201802813


387. Indanol‐Based Chiral Organoiodine Catalysts for Enantioselective Hydrative Dearomatization

Takuya Hashimoto; Yuto Shimazaki; Yamato Omatsu; Keiji Maruoka. Angew. Chem. Int. Ed. 2018, 57, 7200–7204. DOI: 10.1002/anie.201803889


388. Oxidation Catalysis by an Aerobically Generated Dess–Martin Periodinane Analogue

Asim Maity; Sung‐Min Hyun; Alan K. Wortman; David C. Powers. Angew. Chem. Int. Ed. 2018, 57, 7205–7209. DOI: 10.1002/anie.201804159


389. Trimethyl Orthoacetate and Ethylene Glycol Mono‐Vinyl Ether as Enolate Surrogates in Enantioselective Iridium‐Catalyzed Allylation

Yeshua Sempere; Erick M. Carreira. Angew. Chem. Int. Ed. 2018, 57, 7654–7658. DOI: 10.1002/anie.201803558


390. Diverse meta‐C−H Functionalization of Arenes across Different Linker Lengths

Ramasamy Jayarajan; Jayabrata Das; Sukdev Bag; Rajdip Chowdhury; Debabrata Maiti. Angew. Chem. Int. Ed. 2018, 57, 7659–7663. DOI: 10.1002/anie.201804043


391. A Planar‐Chiral Rhodium(III) Catalyst with a Sterically Demanding Cyclopentadienyl Ligand and Its Application in the Enantioselective Synthesis of Dihydroisoquinolones

Evgeniya A. Trifonova; Nikita M. Ankudinov; Andrey A. Mikhaylov; Denis A. Chusov; Yulia V. Nelyubina; Dmitry S. Perekalin. Angew. Chem. Int. Ed. 2018, 57, 7714–7718. DOI: 10.1002/anie.201801703


392. 1,4‐Iron Migration for Expedient Allene Annulations through Iron‐Catalyzed C−H/N−H/C−O/C−H Functionalizations

Jiayu Mo; Thomas Müller; João C. A. Oliveira; Lutz Ackermann. Angew. Chem. Int. Ed. 2018, 57, 7719–7723. DOI: 10.1002/anie.201801324


393. Traversing Steric Limitations by Cooperative Lewis Base/Palladium Catalysis: An Enantioselective Synthesis of α‐Branched Esters Using 2‐Substituted Allyl Electrophiles

Kevin J. Schwarz; Colin M. Pearson; Gabriel A. Cintron‐Rosado; Peng Liu; Thomas N. Snaddon. Angew. Chem. Int. Ed. 2018, 57, 7800–7803. DOI: 10.1002/anie.201803277


394. Metal‐Catalyzed Remote Functionalization of ω‐Ene Unsaturated Ethers: Towards Functionalized Vinyl Species

Guo‐Ming Ho; Lina Judkele; Jeffrey Bruffaerts; Ilan Marek. Angew. Chem. Int. Ed. 2018, 57, 8012–8016. DOI: 10.1002/anie.201802434


395. Enantiodivergent Synthesis of Allenes by Point‐to‐Axial Chirality Transfer

Roly J. Armstrong; Meganathan Nandakumar; Rafael M. P. Dias; Adam Noble; Eddie L. Myers; Varinder K. Aggarwal. Angew. Chem. Int. Ed. 2018, 57, 8203–8208. DOI: 10.1002/anie.201804446


396. Catalytic Enantioselective Cloke–Wilson Rearrangement

Alesandere Ortega; Rubén Manzano; Uxue Uria; Luisa Carrillo; Efraim Reyes; Tomas Tejero; Pedro Merino; Jose L. Vicario. Angew. Chem. Int. Ed. 2018, 57, 8225–8229. DOI: 10.1002/anie.201804614


397. Mapping the Relationship between Glycosyl Acceptor Reactivity and Glycosylation Stereoselectivity

Stefan van der Vorm; Jacob M. A. van Hengst; Marloes Bakker; Herman S. Overkleeft; Gijsbert A. van der Marel; Jeroen D. C. Codée. Angew. Chem. Int. Ed. 2018, 57, 8240–8244. DOI: 10.1002/anie.201802899


398. Copper(I)‐Catalyzed Enantio‐ and Diastereodivergent Borylative Coupling of Styrenes and Imines

Taisuke Itoh; Yamato Kanzaki; Yohei Shimizu; Motomu Kanai. Angew. Chem. Int. Ed. 2018, 57, 8265–8269. DOI: 10.1002/anie.201804117


399. Visible‐Light‐Accelerated Copper(II)‐Catalyzed Regio‐ and Chemoselective Oxo‐Azidation of Vinyl Arenes

Asik Hossain; Adiyala Vidyasagar; Christian Eichinger; Christian Lankes; Jenny Phan; Julia Rehbein; Oliver Reiser. Angew. Chem. Int. Ed. 2018, 57, 8288–8292. DOI: 10.1002/anie.201801678


400. Eosin Y as a Direct Hydrogen‐Atom Transfer Photocatalyst for the Functionalization of C−H Bonds

Xuan‐Zi Fan; Jia‐Wei Rong; Hao‐Lin Wu; Quan Zhou; Hong‐Ping Deng; Jin Da Tan; Cheng‐Wen Xue; Li‐Zhu Wu; Hai‐Rong Tao; Jie Wu. Angew. Chem. Int. Ed. 2018, 57, 8514–8518. DOI: 10.1002/anie.201803220


401. Enantioselective Synthesis of Vicinal All‐Carbon Quaternary Centers via Iridium‐Catalyzed Allylic Alkylation

J. Caleb Hethcox; Samantha E. Shockley; Brian M. Stoltz. Angew. Chem. Int. Ed. 2018, 57, 8664–8667. DOI: 10.1002/anie.201804820


402. A Modified System for the Synthesis of Enantioenriched N‐Arylamines through Copper‐Catalyzed Hydroamination

Saki Ichikawa; Shaolin Zhu; Stephen L. Buchwald. Angew. Chem. Int. Ed. 2018, 57, 8714–8718. DOI: 10.1002/anie.201803026


403. The Important Role of the Byproduct Triphenylphosphine Oxide in the Magnesium(II)‐Catalyzed Enantioselective Reaction of Hemiacetals and Phosphorus Ylides

Linqing Wang; Dongxu Yang; Dan Li; Xihong Liu; Pengxin Wang; Kezhou Wang; Haiyong Zhu; Lutao Bai; Rui Wang. Angew. Chem. Int. Ed. 2018, 57, 9088–9092. DOI: 10.1002/anie.201804177


404. Palladium(II)‐Catalyzed Enantioselective Arylation of Unbiased Methylene C(sp3)−H Bonds Enabled by a 2‐Pyridinylisopropyl Auxiliary and Chiral Phosphoric Acids

Sheng‐Yi Yan; Ye‐Qiang Han; Qi‐Jun Yao; Xing‐Liang Nie; Lei Liu; Bing‐Feng Shi. Angew. Chem. Int. Ed. 2018, 57, 9093–9097. DOI: 10.1002/anie.201804197


405. Enantioselective Synthesis of Chiral Cyclopent‐2‐enones by Nickel‐Catalyzed Desymmetrization of Malonate Esters

Somnath Narayan Karad; Heena Panchal; Christopher Clarke; William Lewis; Hon Wai Lam. Angew. Chem. Int. Ed. 2018, 57, 9122–9125. DOI: 10.1002/anie.201805578


406. Manganese‐Catalyzed Direct Olefination of Methyl‐Substituted Heteroarenes with Primary Alcohols

Milan K. Barman; Satyadeep Waiba; Biplab Maji. Angew. Chem. Int. Ed. 2018, 57, 9126–9130. DOI: 10.1002/anie.201804729


407. Manganese‐Catalyzed Dehydrogenative Alkylation or α‐Olefination of Alkyl‐Substituted N‐Heteroarenes with Alcohols

Guoying Zhang; Torsten Irrgang; Thomas Dietel; Fabian Kallmeier; Rhett Kempe. Angew. Chem. Int. Ed. 2018, 57, 9131–9135. DOI: 10.1002/anie.201801573


408. Designed To React: Terminal Copper Nitrenes and Their Application in Catalytic C−H Aminations

Julian Moegling; Alexander Hoffmann; Fabian Thomas; Nicole Orth; Patricia Liebhäuser; Ulrich Herber; Robert Rampmaier; Julia Stanek; Gerhard Fink; Ivana Ivanović‐Burmazović; Sonja Herres‐Pawlis. Angew. Chem. Int. Ed. 2018, 57, 9154–9159. DOI: 10.1002/anie.201713171


409. Crystallographic Evidence for a Sterically Induced Ferryl Tilt in a Non‐Heme Oxoiron(IV) Complex that Makes it a Better Oxidant

Waqas Rasheed; Apparao Draksharapu; Saikat Banerjee; Victor G. Young; Ruixi Fan; Yisong Guo; M. Ozerov; Joscha Nehrkorn; J. Krzystek; Joshua Telser; Lawrence Que. Angew. Chem. Int. Ed. 2018, 57, 9387–9391. DOI: 10.1002/anie.201804836


410. Cinchonamine Squaramide Catalyzed Asymmetric aza‐Michael Reaction: Dihydroisoquinolines and Tetrahydropyridines

Tarun Kumar Roy; Biswajit Parhi; Prasanta Ghorai. Angew. Chem. Int. Ed. 2018, 57, 9397–9401. DOI: 10.1002/anie.201805020


411. Palladium‐Catalyzed Asymmetric C(sp3)−H Allylation of 2‐Alkylpyridines

Ryo Murakami; Kentaro Sano; Tomohiro Iwai; Tohru Taniguchi; Kenji Monde; Masaya Sawamura. Angew. Chem. Int. Ed. 2018, 57, 9465–9469. DOI: 10.1002/anie.201802821


412. Cross‐Coupling of Alkyl Redox‐Active Esters with Benzophenone Imines: Tandem Photoredox and Copper Catalysis

Runze Mao; Jonathan Balon; Xile Hu. Angew. Chem. Int. Ed. 2018, 57, 9501–9504. DOI: 10.1002/anie.201804873


413. Catalytic C−H Trifluoromethoxylation of Arenes and Heteroarenes

Weijia Zheng; Cristian A. Morales‐Rivera; Johnny W. Lee; Peng Liu; Ming‐Yu Ngai. Angew. Chem. Int. Ed. 2018, 57, 9645–9649. DOI: 10.1002/anie.201800598


414. Hypervalent Iodine(III)‐Catalyzed Balz–Schiemann Fluorination under Mild Conditions

Bo Xing; Chuanfa Ni; Jinbo Hu. Angew. Chem. Int. Ed. 2018, 57, 9896–9900. DOI: 10.1002/anie.201802466


415. Ligand‐Enabled Enantioselective C –H Activation of Tetrahydroquinolines and Saturated Aza‐Heterocycles by RhI

Steffen Greßies; Felix J. R. Klauck; Ju Hyun Kim; Constantin G. Daniliuc; Frank Glorius. Angew. Chem. Int. Ed. 2018, 57, 9950–9954. DOI: 10.1002/anie.201805680


416. Iridium‐Catalyzed, Silyl‐Directed, peri‐Borylation of C−H Bonds in Fused Polycyclic Arenes and Heteroarenes

Bo Su; John F. Hartwig. Angew. Chem. Int. Ed. 2018, 57, 10163–10167. DOI: 10.1002/anie.201805086


417. A Simple, Broad‐Scope Nickel(0) Precatalyst System for the Direct Amination of Allyl Alcohols

Joseph B. Sweeney; Anthony K. Ball; Philippa A. Lawrence; Mackenzie C. Sinclair; Luke J. Smith. Angew. Chem. Int. Ed. 2018, 57, 10202–10206. DOI: 10.1002/anie.201805611


418. Ultrafast Iron‐Catalyzed Reduction of Functionalized Ketones: Highly Enantioselective Synthesis of Halohydrines, Oxaheterocycles, and Aminoalcohols

Clemens K. Blasius; Vladislav Vasilenko; Lutz H. Gade. Angew. Chem. Int. Ed. 2018, 57, 10231–10235. DOI: 10.1002/anie.201806196


419. Steric Effect of Carboxylate Ligands on Pd‐Catalyzed Intramolecular C(sp2)–H and C(sp3)–H Arylation Reactions

Yutaka Tanji; Naoya Mitsutake; Tetsuaki Fujihara; Yasushi Tsuji. Angew. Chem. Int. Ed. 2018, 57, 10314–10317. DOI: 10.1002/anie.201804566


420. Direct Cross‐Coupling of Allylic C(sp3)−H Bonds with Aryl‐ and Vinylbromides by Combined Nickel and Visible‐Light Catalysis

Long Huang; Magnus Rueping. Angew. Chem. Int. Ed. 2018, 57, 10333–10337. DOI: 10.1002/anie.201805118


421. Palladium‐Catalyzed Enantioselective Reductive Heck Reactions: Convenient Access to 3,3‐Disubstituted 2,3‐Dihydrobenzofuran

Zhan‐Ming Zhang; Bing Xu; Yanyan Qian; Lizuo Wu; Yuanqi Wu; Lujia Zhou; Yu Liu; Junliang Zhang. Angew. Chem. Int. Ed. 2018, 57, 10373–10377. DOI: 10.1002/anie.201806372


422. Manganese‐Catalyzed Hydrofunctionalization of Alkenes

Jonathan R. Carney; Barry R. Dillon; Leonie Campbell; Stephen P. Thomas. Angew. Chem. Int. Ed. 2018, 57, 10620–10624. DOI: 10.1002/anie.201805483


423. Exploiting Synergistic Effects in Organozinc Chemistry for Direct Stereoselective C‐Glycosylation Reactions at Room Temperature

Alberto Hernán‐Gómez; Samantha A. Orr; Marina Uzelac; Alan R. Kennedy; Santiago Barroso; Xavier Jusseau; Sébastien Lemaire; Vittorio Farina; Eva Hevia. Angew. Chem. Int. Ed. 2018, 57, 10630–10634. DOI: 10.1002/anie.201805758


424. Organocatalytic Formation of Chiral Trisubstituted Allenes and Chiral Furan Derivatives

Pernille H. Poulsen; Yang Li; Vibeke H. Lauridsen; Danny K. B. Jørgensen; Teresa A. Palazzo; Marta Meazza; Karl Anker Jørgensen. Angew. Chem. Int. Ed. 2018, 57, 10661–10665. DOI: 10.1002/anie.201806238


425. Amidyl Radicals by Oxidation of α‐Amido‐oxy Acids: Transition‐Metal‐Free Amidofluorination of Unactivated Alkenes

Heng Jiang; Armido Studer. Angew. Chem. Int. Ed. 2018, 57, 10707–10711. DOI: 10.1002/anie.201804966


426. An Unexpected α‐Oxidation of Cyclic Ketones with 1,4‐Benzoquinone by Enol Catalysis

Grigory A. Shevchenko; Barry Oppelaar; Benjamin List. Angew. Chem. Int. Ed. 2018, 57, 10756–10759. DOI: 10.1002/anie.201804445


427. Modular One‐Step Three‐Component Synthesis of Tetrahydroisoquinolines Using a Catellani Strategy

Guangyin Qian; Miao Bai; Shijun Gao; Han Chen; Siwei Zhou; Hong‐Gang Cheng; Wei Yan; Qianghui Zhou. Angew. Chem. Int. Ed. 2018, 57, 10980–10984. DOI: 10.1002/anie.201806780


428. Asymmetric Synthesis of Spirocyclic β‐Lactams through Copper‐Catalyzed Kinugasa/Michael Domino Reactions

Tao Shu; Long Zhao; Sun Li; Xiang‐Yu Chen; Carolina von Essen; Kari Rissanen; Dieter Enders. Angew. Chem. Int. Ed. 2018, 57, 10985–10988. DOI: 10.1002/anie.201806931


429. Chiral Phosphoric Acid Catalyzed Asymmetric Synthesis of Hetero‐triarylmethanes from Racemic Indolyl Alcohols

Caizhen Yue; Fei Na; Xiantao Fang; Yang Cao; Jon C. Antilla. Angew. Chem. Int. Ed. 2018, 57, 11004–11008. DOI: 10.1002/anie.201804330


430. A Deprotonation Approach to the Unprecedented Amino‐Trimethylenemethane Chemistry: Regio‐, Diastereo‐, and Enantioselective Synthesis of Complex Amino Cycles

Barry M. Trost; Youliang Wang. Angew. Chem. Int. Ed. 2018, 57, 11025–11029. DOI: 10.1002/anie.201805876


431. Nickel‐Catalyzed Amination of Silyloxyarenes through C–O Bond Activation

Eric M. Wiensch; John Montgomery. Angew. Chem. Int. Ed. 2018, 57, 11045–11049. DOI: 10.1002/anie.201806790


432. A Regio‐ and Diastereoselective Anodic Aryl–Aryl Coupling in the Biomimetic Total Synthesis of (−)‐Thebaine

Alexander Lipp; Dorota Ferenc; Christoph Gütz; Mario Geffe; Nina Vierengel; Dieter Schollmeyer; Hans J. Schäfer; Siegfried R. Waldvogel; Till Opatz. Angew. Chem. Int. Ed. 2018, 57, 11055–11059. DOI: 10.1002/anie.201803887


433. Synthesis of β‐Substituted γ‐Aminobutyric Acid Derivatives through Enantioselective Photoredox Catalysis

Jiajia Ma; Jiahui Lin; Lifang Zhao; Klaus Harms; Michael Marsch; Xiulan Xie; Eric Meggers. Angew. Chem. Int. Ed. 2018, 57, 11193–11197. DOI: 10.1002/anie.201804040


434. HFIP‐Assisted C−H Functionalization by Cp*CoIII: Access to Key Reactive Cobaltacycles and Implication in Catalysis

Jesús Sanjosé‐Orduna; Juan Manuel Sarria Toro; Mónica H. Pérez‐Temprano. Angew. Chem. Int. Ed. 2018, 57, 11369–11373. DOI: 10.1002/anie.201806847


435. Catalytic Enantioselective Synthesis of α‐Chiral Azaheteroaryl Ethylamines by Asymmetric Protonation

Chao Xu; Calum W. Muir; Andrew G. Leach; Alan R. Kennedy; Allan J. B. Watson. Angew. Chem. Int. Ed. 2018, 57, 11374–11377. DOI: 10.1002/anie.201806956


436. Iron(II)‐Catalyzed Site‐Selective Functionalization of Unactivated C(sp3)−H Bonds Guided by Alkoxyl Radicals

Honghao Guan; Shutao Sun; Ying Mao; Lei Chen; Ran Lu; Jiancheng Huang; Lei Liu. Angew. Chem. Int. Ed. 2018, 57, 11413–11417. DOI: 10.1002/anie.201806434


437. Regiospecific N‐Arylation of Aliphatic Amines under Mild and Metal‐Free Reaction Conditions

Nibadita Purkait; Gabriella Kervefors; Erika Linde; Berit Olofsson. Angew. Chem. Int. Ed. 2018, 57, 11427–11431. DOI: 10.1002/anie.201807001


438. Enantioselective Nazarov Cyclizations Catalyzed by an Axial Chiral C6F5‐Substituted Boron Lewis Acid

Lars Süsse; Maria Vogler; Marius Mewald; Benedict Kemper; Elisabeth Irran; Martin Oestreich. Angew. Chem. Int. Ed. 2018, 57, 11441–11444. DOI: 10.1002/anie.201806011


439. Asymmetric Catalytic Preparation of Polysubstituted Cyclopropanol and Cyclopropylamine Derivatives

Marwan Simaan; Ilan Marek. Angew. Chem. Int. Ed. 2018, 57, 1543–1546. DOI: 10.1002/anie.201710707


440. Pd‐Catalyzed Enantioselective [6+4] Cycloaddition of Vinyl Oxetanes with Azadienes to Access Ten‐Membered Heterocycles

Ya‐Nong Wang; Li‐Cheng Yang; Zi‐Qiang Rong; Tang‐Lin Liu; Ruoyang Liu; Yu Zhao. Angew. Chem. Int. Ed. 2018, 57, 1596–1600. DOI: 10.1002/anie.201711648


441. Catalytic Asymmetric Oxidative γ‐Coupling of α,β‐Unsaturated Aldehydes with Air as the Terminal Oxidant

Line Næsborg; Vasco Corti; Lars Astrup Leth; Pernille H. Poulsen; Karl Anker Jørgensen. Angew. Chem. Int. Ed. 2018, 57, 1606–1610. DOI: 10.1002/anie.201711944


442. Electrochemical Synthesis of Imidazo‐Fused N‐Heteroaromatic Compounds through a C−N Bond‐Forming Radical Cascade

Zhong‐Wei Hou; Zhong‐Yi Mao; Yared Yohannes Melcamu; Xin Lu; Hai‐Chao Xu. Angew. Chem. Int. Ed. 2018, 57, 1636–1639. DOI: 10.1002/anie.201711876


443. Tertiary‐Alcohol‐Directed Functionalization of Remote C(sp3)−H Bonds by Sequential Hydrogen Atom and Heteroaryl Migrations

Xinxin Wu; Mingyang Wang; Leitao Huan; Dongping Wang; Jinwei Wang; Chen Zhu. Angew. Chem. Int. Ed. 2018, 57, 1640–1644. DOI: 10.1002/anie.201709025


444. Highly Regio‐ and Stereodivergent Access to 1,2‐Amino Alcohols or 1,4‐Fluoro Alcohols by NHC‐Catalyzed Ring Opening of Epoxy enals

Si Bei Poh; Jun‐Yang Ong; Shenci Lu; Yu Zhao. Angew. Chem. Int. Ed. 2018, 57, 1645–1649. DOI: 10.1002/anie.201709823


445. Potassium Amide‐Catalyzed Benzylic C−H Bond Addition of Alkylpyridines to Styrenes

Dan‐Dan Zhai; Xiang‐Yu Zhang; Yu‐Feng Liu; Lei Zheng; Bing‐Tao Guan. Angew. Chem. Int. Ed. 2018, 57, 1650–1653. DOI: 10.1002/anie.201710128


446. Cobalt‐Catalyzed Diborylation of 1,1‐disubstituted Vinylarenes: A Practical Route to Branched gem‐Bis(boryl)alkanes

Wei Jie Teo; Shaozhong Ge. Angew. Chem. Int. Ed. 2018, 57, 1654–1658. DOI: 10.1002/anie.201710389


447. α‐Aminoxy‐Acid‐Auxiliary‐Enabled Intermolecular Radical γ‐C(sp3)−H Functionalization of Ketones

Heng Jiang; Armido Studer. Angew. Chem. Int. Ed. 2018, 57, 1692–1696. DOI: 10.1002/anie.201712066


448. Direct Annulation between Aryl Iodides and Epoxides through Palladium/Norbornene Cooperative Catalysis

Renhe Li; Guangbin Dong. Angew. Chem. Int. Ed. 2018, 57, 1697–1701. DOI: 10.1002/anie.201712393


449. Rhodium‐Catalyzed Enantioposition‐Selective Hydroarylation of Divinylphosphine Oxides with Aryl Boroxines

Zhe Wang; Tamio Hayashi. Angew. Chem. Int. Ed. 2018, 57, 1702–1706. DOI: 10.1002/anie.201712572


450. Efficient Synthesis of Arylated Furans by a Sequential Rh‐Catalyzed Arylation and Cycloisomerization of Cyclopropenes

Xiaoming Wang; Andreas Lerchen; Constantin G. Daniliuc; Frank Glorius. Angew. Chem. Int. Ed. 2018, 57, 1712–1716. DOI: 10.1002/anie.201712019


451. Palladium(II)‐Mediated C−H Tritiation of Complex Pharmaceuticals

Haifeng Yang; Peter G. Dormer; Nelo R. Rivera; Andrew J. Hoover. Angew. Chem. Int. Ed. 2018, 57, 1883–1887. DOI: 10.1002/anie.201711364


452. Stereoselective Construction of Halogenated Quaternary Carbon Centers by Brønsted Base Catalyzed [4+2] Cycloaddition of α‐Haloaldehydes

Qiang Li; Liang Zhou; Xu‐Dong Shen; Kai‐Chuan Yang; Xiang Zhang; Qing‐Song Dai; Hai‐Jun Leng; Qing‐Zhu Li; Jun‐Long Li. Angew. Chem. Int. Ed. 2018, 57, 1913–1917. DOI: 10.1002/anie.201711813


453. Direct Asymmetric Michael Reaction of α,β‐Unsaturated Aldehydes and Ketones Catalyzed by Two Secondary Amine Catalysts

Yujiro Hayashi; Nariyoshi Umekubo. Angew. Chem. Int. Ed. 2018, 57, 1958–1962. DOI: 10.1002/anie.201710085


454. Synthesis of Phenols: Organophotoredox/Nickel Dual Catalytic Hydroxylation of Aryl Halides with Water

Liu Yang; Zhiyan Huang; Gang Li; Wei Zhang; Rui Cao; Chao Wang; Jianliang Xiao; Dong Xue. Angew. Chem. Int. Ed. 2018, 57, 1968–1972. DOI: 10.1002/anie.201710698


455. Barbier–Negishi Coupling of Secondary Alkyl Bromides with Aryl and Alkenyl Triflates and Nonaflates

Ke‐Feng Zhang; Fadri Christoffel; Olivier Baudoin. Angew. Chem. Int. Ed. 2018, 57, 1982–1986. DOI: 10.1002/anie.201711990


456. Palladium‐Catalyzed Enantioselective Desymmetrizing Aza‐Wacker Reaction: Development and Application to the Total Synthesis of (−)‐Mesembrane and (+)‐Crinane

Xu Bao; Qian Wang; Jieping Zhu. Angew. Chem. Int. Ed. 2018, 57, 1995–1999. DOI: 10.1002/anie.201712521


457. Enantioselective Polyene Cyclization Catalyzed by a Chiral Brønsted Acid

Liwen Fan; Chunyu Han; Xuerong Li; Jiasheng Yao; Zhengning Wang; Chaochao Yao; Weihao Chen; Tao Wang; Junfeng Zhao. Angew. Chem. Int. Ed. 2018, 57, 2115–2119. DOI: 10.1002/anie.201711603


458. Stereodivergent Synthesis of Tetrahydrofuroindoles through Pd‐Catalyzed Asymmetric Dearomative Formal [3+2] Cycloaddition

Qiang Cheng; Fang Zhang; Yue Cai; Yin‐Long Guo; Shu‐Li You. Angew. Chem. Int. Ed. 2018, 57, 2134–2138. DOI: 10.1002/anie.201711873


459. Visible‐Light‐Mediated Decarboxylative Radical Additions to Vinyl Boronic Esters: Rapid Access to γ‐Amino Boronic Esters

Adam Noble; Riccardo S. Mega; Daniel Pflästerer; Eddie L. Myers; Varinder K. Aggarwal. Angew. Chem. Int. Ed. 2018, 57, 2155–2159. DOI: 10.1002/anie.201712186


460. Direct Synthesis of Polysubstituted Aldehydes via Visible‐Light Catalysis

Fengjin Wu; Leifeng Wang; Jiean Chen; David A. Nicewicz; Yong Huang. Angew. Chem. Int. Ed. 2018, 57, 2174–2178. DOI: 10.1002/anie.201712384


461. Total Synthesis of (+)‐Gracilamine Based on an Oxidative Phenolic Coupling Reaction and Determination of Its Absolute Configuration

Minami Odagi; Yoshiharu Yamamoto; Kazuo Nagasawa. Angew. Chem. Int. Ed. 2018, 57, 2229–2232. DOI: 10.1002/anie.201708575


462. Catalytic Asymmetric Synthesis of Trifluoromethylated γ‐Amino Acids through the Umpolung Addition of Trifluoromethyl Imines to Carboxylic Acid Derivatives

Bin Hu; Li Deng. Angew. Chem. Int. Ed. 2018, 57, 2233–2237. DOI: 10.1002/anie.201710915


463. Cobalt(II)‐based Metalloradical Activation of 2‐(Diazomethyl)pyridines for Radical Transannulation and Cyclopropanation

Satyajit Roy; Sandip Kumar Das; Buddhadeb Chattopadhyay. Angew. Chem. Int. Ed. 2018, 57, 2238–2243. DOI: 10.1002/anie.201711209


464. Catalytic Desymmetrizing Dehydrogenation of 4‐Substituted Cyclohexanones through Enamine Oxidation

Lihui Zhu; Long Zhang; Sanzhong Luo. Angew. Chem. Int. Ed. 2018, 57, 2253–2258. DOI: 10.1002/anie.201713327


465. Enantio‐ and Diastereoselective Cyclopropanation of 1‐Alkenylboronates: Synthesis of 1‐Boryl‐2,3‐Disubstituted Cyclopropanes

Javier Carreras; Ana Caballero; Pedro J. Pérez. Angew. Chem. Int. Ed. 2018, 57, 2334–2338. DOI: 10.1002/anie.201710415


466. Palladium‐Catalyzed Asymmetric Aminohydroxylation of 1,3‐Dienes

Hong‐Cheng Shen; Yu‐Feng Wu; Ying Zhang; Lian‐Feng Fan; Zhi‐Yong Han; Liu‐Zhu Gong. Angew. Chem. Int. Ed. 2018, 57, 2372–2376. DOI: 10.1002/anie.201712350


467. Electrochemical C−H/N−H Activation by Water‐Tolerant Cobalt Catalysis at Room Temperature

Cong Tian; Leonardo Massignan; Tjark H. Meyer; Lutz Ackermann. Angew. Chem. Int. Ed. 2018, 57, 2383–2387. DOI: 10.1002/anie.201712647


468. Synthesis and Structure Revision of Dichrocephones A and B

Volker M. Schmiedel; Young J. Hong; Dieter Lentz; Dean J. Tantillo; Mathias Christmann. Angew. Chem. Int. Ed. 2018, 57, 2419–2422. DOI: 10.1002/anie.201711766


469. The Enantioselective Total Synthesis of Bisquinolizidine Alkaloids: A Modular “Inside‐Out” Approach

Dagmar Scharnagel; Jessica Goller; Nicklas Deibl; Wolfgang Milius; Matthias Breuning. Angew. Chem. Int. Ed. 2018, 57, 2432–2435. DOI: 10.1002/anie.201712852


470. Synthesis of α‐Chiral Ketones and Chiral Alkanes Using Radical Polar Crossover Reactions of Vinyl Boron Ate Complexes

Carolin Gerleve; Marvin Kischkewitz; Armido Studer. Angew. Chem. Int. Ed. 2018, 57, 2441–2444. DOI: 10.1002/anie.201711390


471. The Catalytic Asymmetric Mukaiyama–Michael Reaction of Silyl Ketene Acetals with α,β‐Unsaturated Methyl Esters

Tim Gatzenmeier; Philip S. J. Kaib; Julia B. Lingnau; Richard Goddard; Benjamin List. Angew. Chem. Int. Ed. 2018, 57, 2464–2468. DOI: 10.1002/anie.201712088


472. Reductive Amination by Photoredox Catalysis and Polarity‐Matched Hydrogen Atom Transfer

Xingwei Guo; Oliver S. Wenger. Angew. Chem. Int. Ed. 2018, 57, 2469–2473. DOI: 10.1002/anie.201711467


473. Dual Ligand‐Enabled Nondirected C−H Olefination of Arenes

Hao Chen; Philipp Wedi; Tim Meyer; Ghazal Tavakoli; Manuel van Gemmeren. Angew. Chem. Int. Ed. 2018, 57, 2497–2501. DOI: 10.1002/anie.201712235


474. Synthesis of Difluoromethylthioesters from Aldehydes

Shi‐Huan Guo; Xing‐Long Zhang; Gao‐Fei Pan; Xue‐Qing Zhu; Ya‐Ru Gao; Yong‐Qiang Wang. Angew. Chem. Int. Ed. 2018, 57, 1663–1667. DOI: 10.1002/anie.201710731


475. Photocatalytic Aerobic Phosphatation of Alkenes

Christian Depken; Felix Krätzschmar; Rene Rieger; Katharina Rode; Alexander Breder. Angew. Chem. Int. Ed. 2018, 57, 2459–2463. DOI: 10.1002/anie.201711599


476. Mechanism‐Based Condition Screening for Sustainable Catalysis in Single‐Electron Steps by Cyclic Voltammetry

Theresa Liedtke; Peter Spannring; Ludovico Riccardi; Andreas Gansäuer. Angew. Chem. Int. Ed. 2018, 57, 5006–5010. DOI: 10.1002/anie.201800731


477. Inversion of Configuration at the Phosphorus Nucleophile in the Diastereoselective and Enantioselective Synthesis of P‐Stereogenic syn‐Phosphiranes from Chiral Epoxides

Jake A. Muldoon; Balázs R. Varga; Meaghan M. Deegan; Timothy W. Chapp; Ádám M. Eördögh; Russell P. Hughes; David S. Glueck; Curtis E. Moore; Arnold L. Rheingold. Angew. Chem. Int. Ed. 2018, 57, 5047–5051. DOI: 10.1002/anie.201801427


478. Photocatalyzed ortho‐Alkylation of Pyridine N‐Oxides through Alkene Cleavage

Wang Zhou; Tomoya Miura; Masahiro Murakami. Angew. Chem. Int. Ed. 2018, 57, 5139–5142. DOI: 10.1002/anie.201801305


479. Designing Homogeneous Bromine Redox Catalysis for Selective Aliphatic C−H Bond Functionalization

Peter Becker; Thomas Duhamel; Claudio Martínez; Kilian Muñiz. Angew. Chem. Int. Ed. 2018, 57, 5166–5170. DOI: 10.1002/anie.201800375


480. One‐Pot Tandem Photoredox and Cross‐Coupling Catalysis with a Single Palladium Carbodicarbene Complex

Yu‐Cheng Hsu; Vincent C.‐C. Wang; Ka‐Chun Au‐Yeung; Chung‐Yu Tsai; Chun‐Chi Chang; Bo‐Chao Lin; Yi010;Tsu Chan; Chao‐Ping Hsu; Glenn P. A. Yap; Titel Jurca; Tiow‐Gan Ong. Angew. Chem. Int. Ed. 2018, 57, 4622–4626. DOI: 10.1002/anie.201800951


481. Synergistic Photoredox Catalysis and Organocatalysis for Inverse Hydroboration of Imines

Nengneng Zhou; Xiang‐Ai Yuan; Yue Zhao; Jin Xie; Chengjian Zhu. Angew. Chem. Int. Ed. 2018, 57, 3990–3994. DOI: 10.1002/anie.201800421


482. NiH‐Catalyzed Reductive Relay Hydroalkylation: A Strategy for the Remote C(sp3)−H Alkylation of Alkenes

Fang Zhou; Jin Zhu; Yao Zhang; Shaolin Zhu. Angew. Chem. Int. Ed. 2018, 57, 4058–4062. DOI: 10.1002/anie.201712731


483. Palladium‐Catalyzed Decarbonylative Trifluoromethylation of Acid Fluorides

Sinead T. Keaveney; Franziska Schoenebeck. Angew. Chem. Int. Ed. 2018, 57, 4073–4077. DOI: 10.1002/anie.201800644


484. γ‐, Diastereo‐, and Enantioselective Addition of MEMO‐Substituted Allylboron Compounds to Aldimines Catalyzed by Organoboron–Ammonium Complexes

Ryan J. Morrison; Amir H. Hoveyda. Angew. Chem. Int. Ed. 2018, 57, 11654–11661. DOI: 10.1002/anie.201805811


485. Mechanistic Studies on the Organocatalytic α‐Chlorination of Aldehydes: The Role and Nature of Off‐Cycle Intermediates

Sebastian Ponath; Martina Menger; Lydia Grothues; Manuela Weber; Dieter Lentz; Carsten Strohmann; Mathias Christmann. Angew. Chem. Int. Ed. 2018, 57, 11683–11687. DOI: 10.1002/anie.201806261


486. (P,C) Cyclometalated Gold(III) Complexes: Highly Active Catalysts for the Hydroarylation of Alkynes

Charlie Blons; Sonia Mallet‐Ladeira; Abderrahmane Amgoune; Didier Bourissou. Angew. Chem. Int. Ed. 2018, 57, 11732–11736. DOI: 10.1002/anie.201807106


487. Visible‐Light‐Mediated Metal‐Free Synthesis of Trifluoromethylselenolated Arenes

Clément Ghiazza; Vincent Debrauwer; Cyrille Monnereau; Lhoussain Khrouz; Maurice Médebielle; Thierry Billard; Anis Tlili. Angew. Chem. Int. Ed. 2018, 57, 11781–11785. DOI: 10.1002/anie.201806165


488. Metal‐Free Direct C−H Cyanation of Alkenes

Xi Wang; Armido Studer. Angew. Chem. Int. Ed. 2018, 57, 11792–11796. DOI: 10.1002/anie.201807303


489. Nickel‐Catalyzed Stereospecific C−H Coupling of Benzamides with Epoxides

Shibo Xu; Kazutaka Takamatsu; Koji Hirano; Masahiro Miura. Angew. Chem. Int. Ed. 2018, 57, 11797–11801. DOI: 10.1002/anie.201807664


490. Cu‐Catalyzed Cross‐Dehydrogenative ortho‐Aminomethylation of Phenols

Congjun Yu; Frederic W. Patureau. Angew. Chem. Int. Ed. 2018, 57, 11807–11811. DOI: 10.1002/anie.201804829


491. N‐Heterocyclic Carbene Iron(III) Porphyrin‐Catalyzed Intramolecular C(sp3)–H Amination of Alkyl Azides

Ka‐Pan Shing; Yungen Liu; Bei Cao; Xiao‐Yong Chang; Tingjie You; Chi‐Ming Che. Angew. Chem. Int. Ed. 2018, 57, 11947–11951. DOI: 10.1002/anie.201806059


492. Terminal Alkyne Coupling Reactions through a Ring: Mechanistic Insights and Regiochemical Switching

Caroline M. Storey; Matthew R. Gyton; Rhiann E. Andrew; Adrian B. Chaplin. Angew. Chem. Int. Ed. 2018, 57, 12003–12006. DOI: 10.1002/anie.201807028


493. Chiral Carboxylic Acid Enabled Achiral Rhodium(III)‐Catalyzed Enantioselective C−H Functionalization

Luqing Lin; Seiya Fukagawa; Daichi Sekine; Eiki Tomita; Tatsuhiko Yoshino; Shigeki Matsunaga. Angew. Chem. Int. Ed. 2018, 57, 12048–12052. DOI: 10.1002/anie.201807610


494. NHC‐Catalyzed Electrophilic Trifluoromethylation: Efficient Synthesis of γ‐Trifluoromethyl α,β‐Unsaturated Esters

Wen Yang; Dengke Ma; Yu Zhou; Xiuqin Dong; Zhenyang Lin; Jianwei Sun. Angew. Chem. Int. Ed. 2018, 57, 12097–12101. DOI: 10.1002/anie.201806674


495. A Continuously Regenerable Chiral Ammonia Borane for Asymmetric Transfer Hydrogenations

Qiwen Zhou; Wei Meng; Jing Yang; Haifeng Du. Angew. Chem. Int. Ed. 2018, 57, 12111–12115. DOI: 10.1002/anie.201806877


496. Copper‐Catalyzed Tandem Hydrocupration and Diastereo‐ and Enantioselective Borylalkyl Addition to Aldehydes

Won Jun Jang; Jaesook Yun. Angew. Chem. Int. Ed. 2018, 57, 12116–12120. DOI: 10.1002/anie.201806937


497. Metal‐ and Reagent‐Free Dehydrogenative Formal Benzyl–Aryl Cross‐Coupling by Anodic Activation in 1,1,1,3,3,3‐Hexafluoropropan‐2‐ol

Yasushi Imada; Johannes L. Röckl; Anton Wiebe; Tile Gieshoff; Dieter Schollmeyer; Kazuhiro Chiba; Robert Franke; Siegfried R. Waldvogel. Angew. Chem. Int. Ed. 2018, 57, 12136–12140. DOI: 10.1002/anie.201804997


498. Enantioconvergent Biocatalytic Redox Isomerization

Yu‐Chang Liu; Christian Merten; Jan Deska. Angew. Chem. Int. Ed. 2018, 57, 12151–12156. DOI: 10.1002/anie.201804911


499. Can a Ketone Be More Reactive than an Aldehyde? Catalytic Asymmetric Synthesis of Substituted Tetrahydrofurans

Sunggi Lee; Han Yong Bae; Benjamin List. Angew. Chem. Int. Ed. 2018, 57, 12162–12166. DOI: 10.1002/anie.201806312


500. Visible Light Mediated Aryl Migration by Homolytic C−N Cleavage of Aryl Amines

Dirk Alpers; Kevin P. Cole; Corey R. J. Stephenson. Angew. Chem. Int. Ed. 2018, 57, 12167–12170. DOI: 10.1002/anie.201806659


501. Intramolecular Aryl Migration of Diaryliodonium Salts: Access to ortho‐Iodo Diaryl Ethers

Huangguan Chen; Jianwei Han; Limin Wang. Angew. Chem. Int. Ed. 2018, 57, 12313–12317. DOI: 10.1002/anie.201806405


502. Enantioselective Construction of Silicon‐Stereogenic Silanes by Scandium‐Catalyzed Intermolecular Alkene Hydrosilylation

Gu Zhan; Huai‐Long Teng; Yong Luo; Shao‐Jie Lou; Masayoshi Nishiura; Zhaomin Hou. Angew. Chem. Int. Ed. 2018, 57, 12342–12346. DOI: 10.1002/anie.201807493


503. Palladium‐Catalyzed γ‐C(sp3)−H Arylation of Thiols by a Detachable Protecting/Directing Group

Likun Jin; Jianchun Wang; Guangbin Dong. Angew. Chem. Int. Ed. 2018, 57, 12352–12355. DOI: 10.1002/anie.201807760


504. The Hydrazine–O2 Redox Couple as a Platform for Organocatalytic Oxidation: Benzo[c]cinnoline‐Catalyzed Oxidation of Alkyl Halides to Aldehydes

Ilana B. Stone; Janis Jermaks; Samantha N. MacMillan; Tristan H. Lambert. Angew. Chem. Int. Ed. 2018, 57, 12494–12498. DOI: 10.1002/anie.201807134


505. A Unified Approach to Couple Aromatic Heteronucleophiles to Azines and Pharmaceuticals

Ryan G. Anderson; Brianna M. Jett; Andrew McNally. Angew. Chem. Int. Ed. 2018, 57, 12514–12518. DOI: 10.1002/anie.201807322


506. Metallaphotoredox Difluoromethylation of Aryl Bromides

Vlad Bacauanu; Sébastien Cardinal; Motoshi Yamauchi; Masaru Kondo; David F. Fernández; Richard Remy; David W. C. MacMillan. Angew. Chem. Int. Ed. 2018, 57, 12543–12548. DOI: 10.1002/anie.201807629


507. Modular Functionalization of Arenes in a Triply Selective Sequence: Rapid C(sp2) and C(sp3) Coupling of C−Br, C−OTf, and C−Cl Bonds Enabled by a Single Palladium(I) Dimer

Sinead T. Keaveney; Gourab Kundu; Franziska Schoenebeck. Angew. Chem. Int. Ed. 2018, 57, 12573–12577. DOI: 10.1002/anie.201808386


508. Microtubing‐Reactor‐Assisted Aliphatic C−H Functionalization with HCl as a Hydrogen‐Atom‐Transfer Catalyst Precursor in Conjunction with an Organic Photoredox Catalyst

Hong‐Ping Deng; Quan Zhou; Jie Wu. Angew. Chem. Int. Ed. 2018, 57, 12661–12665. DOI: 10.1002/anie.201804844


509. Exploration of the Synthetic Potential of Electrophilic Trifluoromethylthiolating and Difluoromethylthiolating Reagents

Jingjing Zhang; Jin‐Dong Yang; Hanliang Zheng; Xiao‐Song Xue; Herbert Mayr; Jin‐Pei Cheng. Angew. Chem. Int. Ed. 2018, 57, 12690–12695. DOI: 10.1002/anie.201805859


510. Site‐Selective, Late‐Stage C−H 18F‐Fluorination on Unprotected Peptides for Positron Emission Tomography Imaging

Zheliang Yuan; Matthew B. Nodwell; Hua Yang; Noeen Malik; Helen Merkens; François Bénard; Rainer E. Martin; Paul Schaffer; Robert Britton. Angew. Chem. Int. Ed. 2018, 57, 12733–12736. DOI: 10.1002/anie.201806966


511. Dramatically Enhanced Solubility of Halide‐Containing Organometallic Species in Diiodomethane: The Role of Solvent⋅⋅⋅Complex Halogen Bonding

Mikhail A. Kinzhalov; Mariya V. Kashina; Alexander S. Mikherdov; Ekaterina A. Mozheeva; Alexander S. Novikov; Andrey S. Smirnov; Daniil M. Ivanov; Mariya A. Kryukova; Aleksandr Yu. Ivanov; Sergej N. Smirnov; Vadim Yu. Kukushkin; Konstantin V. Luzyanin. Angew. Chem. Int. Ed. 2018, 57, 12785–12789. DOI: 10.1002/anie.201807642


512. Enantioselective Construction of Tertiary Boronic Esters by Conjunctive Cross‐Coupling

Jesse A. Myhill; Liang Zhang; Gabriel J. Lovinger; James P. Morken. Angew. Chem. Int. Ed. 2018, 57, 12799–12803. DOI: 10.1002/anie.201807775


513. Photoinduced Remote Functionalization of Amides and Amines Using Electrophilic Nitrogen Radicals

Sara P. Morcillo; Elizabeth M. Dauncey; Ji Hye Kim; James J. Douglas; Nadeem S. Sheikh; Daniele Leonori. Angew. Chem. Int. Ed. 2018, 57, 12945–12949. DOI: 10.1002/anie.201807941


514. A General Approach to Site‐Specific, Intramolecular C−H Functionalization Using Dithiocarbamates

Christina G. Na; Erik J. Alexanian. Angew. Chem. Int. Ed. 2018, 57, 13106–13109. DOI: 10.1002/anie.201806963


515. Enantioselective Synthesis of Tertiary Allylic Fluorides by Iridium‐Catalyzed Allylic Fluoroalkylation

Trevor W. Butcher; John F. Hartwig. Angew. Chem. Int. Ed. 2018, 57, 13125–13129. DOI: 10.1002/anie.201807474


516. Catalytic Enantioselective [10+4] Cycloadditions

Bjarke S. Donslund; Nicolaj Inunnguaq Jessen; Giulio Bertuzzi; Maxime Giardinetti; Teresa A. Palazzo; Mette Louise Christensen; Karl Anker Jørgensen. Angew. Chem. Int. Ed. 2018, 57, 13182–13186. DOI: 10.1002/anie.201807830


517. Photoinduced Palladium‐Catalyzed Negishi Cross‐Couplings Enabled by the Visible‐Light Absorption of Palladium–Zinc Complexes

Irini Abdiaj; Lena Huck; José Miguel Mateo; Antonio de la Hoz; M. Victoria Gomez; Angel Díaz‐Ortiz; Jesús Alcázar. Angew. Chem. Int. Ed. 2018, 57, 13231–13236. DOI: 10.1002/anie.201808654


518. Regioselective Metal‐ and Reagent‐Free Arylation of Benzothiophenes by Dehydrogenative Electrosynthesis

Sebastian Lips; Dieter Schollmeyer; Robert Franke; Siegfried R. Waldvogel. Angew. Chem. Int. Ed. 2018, 57, 13325–13329. DOI: 10.1002/anie.201808555


519. Metal‐Free and Redox‐Neutral Conversion of Organotrifluoroborates into Radicals Enabled by Visible Light

Wenbo Liu; Peng Liu; Leiyang Lv; Chao‐Jun Li. Angew. Chem. Int. Ed. 2018, 57, 13499–13503. DOI: 10.1002/anie.201807181


520. Catalytic Regio‐ and Enantioselective Alkylation of Conjugated Dienyl Amides

Yafei Guo; Johanan Kootstra; Syuzanna R. Harutyunyan. Angew. Chem. Int. Ed. 2018, 57, 13547–13550. DOI: 10.1002/anie.201808392


521. Catalytic Alkyne Arylation Using Traceless Directing Groups

Jung‐Woo Park; Bubwoong Kang; Vy M. Dong. Angew. Chem. Int. Ed. 2018, 57, 13598–13602. DOI: 10.1002/anie.201804955


522. Measuring the Relative Reactivity of the Carbon–Hydrogen Bonds of Alkanes as Nucleophiles

Andrea Olmos; Riccardo Gava; Bárbara Noverges; Delia Bellezza; Kane Jacob; Maria Besora; W. M. Chamil Sameera; Michel Etienne; Feliu Maseras; Gregorio Asensio; Ana Caballero; Pedro J. Pérez. Angew. Chem. Int. Ed. 2018, 57, 13848–13852. DOI: 10.1002/anie.201807448


523. trans‐Cyclooctenes as Halolactonization Catalysts

Shunsuke Einaru; Kenta Shitamichi; Tagui Nagano; Akira Matsumoto; Keisuke Asano; Seijiro Matsubara. Angew. Chem. Int. Ed. 2018, 57, 13863–13867. DOI: 10.1002/anie.201808320


524. Cobalt‐Catalyzed Reductive Dimethylcyclopropanation of 1,3‐Dienes

Jacob Werth; Christopher Uyeda. Angew. Chem. Int. Ed. 2018, 57, 13902–13906. DOI: 10.1002/anie.201807542


525. Enantioselective Intramolecular Nicholas Reaction Catalyzed by Chiral Phosphoric Acid: Enantioconvergent Synthesis of Seven‐Membered Cyclic Ethers from Racemic Diols

Yusuke Ota; Azusa Kondoh; Masahiro Terada. Angew. Chem. Int. Ed. 2018, 57, 13917–13921. DOI: 10.1002/anie.201808239


526. Site‐Specific Deoxyfluorination of Small Peptides with [18F]Fluoride

Jens Rickmeier; Tobias Ritter. Angew. Chem. Int. Ed. 2018, 57, 14207–14211. DOI: 10.1002/anie.201807983


527. A Versatile Bis‐Allylboron Reagent for the Stereoselective Synthesis of Chiral Diols

Belinda E. Hetzler; Giulio Volpin; Elisa Vignoni; Ana G. Petrovic; Gloria Proni; Chunhua T. Hu; Dirk Trauner. Angew. Chem. Int. Ed. 2018, 57, 14276–14280. DOI: 10.1002/anie.201808234


528. Nickel‐Catalyzed Enantioconvergent Borylation of Racemic Secondary Benzylic Electrophiles

Zhaobin Wang; Shoshana Bachman; Alexander S. Dudnik; Gregory C. Fu. Angew. Chem. Int. Ed. 2018, 57, 14529–14532. DOI: 10.1002/anie.201806015


529. A General Amino Acid Synthesis Enabled by Innate Radical Cross‐Coupling

Shengyang Ni; Alberto F. Garrido‐Castro; Rohan R. Merchant; Justine N. de Gruyter; Daniel C. Schmitt; James J. Mousseau; Gary M. Gallego; Shouliang Yang; Michael R. Collins; Jennifer X. Qiao; Kap‐Sun Yeung; David R. Langley; Michael A. Poss; Paul M. Scola; Tian Qin; Phil S. Baran. Angew. Chem. Int. Ed. 2018, 57, 14560–14565. DOI: 10.1002/anie.201809310


530. Brønsted Acid‐Catalyzed Carbonyl‐Olefin Metathesis inside a Self‐Assembled Supramolecular Host

Lorenzo Catti; Konrad Tiefenbacher. Angew. Chem. Int. Ed. 2018, 57, 14589–14592. DOI: 10.1002/anie.201712141


531. Enantioselective Lewis Acid Catalyzed ortho Photocycloaddition of Olefins to Phenanthrene‐9‐carboxaldehydes

Simone Stegbauer; Christian Jandl; Thorsten Bach. Angew. Chem. Int. Ed. 2018, 57, 14593–14596. DOI: 10.1002/anie.201808919


532. Palladium‐Catalyzed Enantioselective Addition of Chiral Metal Enolates to In Situ Generated ortho‐Quinone Methides

Fabian Göricke; Christoph Schneider. Angew. Chem. Int. Ed. 2018, 57, 14736–14741. DOI: 10.1002/anie.201809692


533. Intermolecular Allylic C−H Etherification of Internal Olefins

Taylor A. F. Nelson; Simon B. Blakey. Angew. Chem. Int. Ed. 2018, 57, 14911–14915. DOI: 10.1002/anie.201809863


534. Cathode Material Determines Product Selectivity for Electrochemical C−H Functionalization of Biaryl Ketoximes

Huai‐Bo Zhao; Pin Xu; Jinshuai Song; Hai‐Chao Xu. Angew. Chem. Int. Ed. 2018, 57, 15153–15156. DOI: 10.1002/anie.201809679


535. Mannich‐type Reactions of Cyclic Nitrones: Effective Methods for the Enantioselective Synthesis of Piperidine‐containing Alkaloids

Vladislav G. Lisnyak; Tessa Lynch‐Colameta; Scott A. Snyder. Angew. Chem. Int. Ed. 2018, 57, 15162–15166. DOI: 10.1002/anie.201809799


536. Non‐Directed Cross‐Dehydrogenative (Hetero)arylation of Allylic C(sp3)−H bonds enabled by C−H Activation

Andreas Lerchen; Tobias Knecht; Maximilian Koy; Johannes B. Ernst; Klaus Bergander; Constantin G. Daniliuc; Frank Glorius. Angew. Chem. Int. Ed. 2018, 57, 15248–15252. DOI: 10.1002/anie.201807047


537. Synthesis of Functionalized Cyclopropanes from Carboxylic Acids by a Radical Addition–Polar Cyclization Cascade

Chao Shu; Riccardo S. Mega; Björn J. Andreassen; Adam Noble; Varinder K. Aggarwal. Angew. Chem. Int. Ed. 2018, 57, 15430–15434. DOI: 10.1002/anie.201808598


538. Solid‐Phase Conversion of Four Stereoisomers into a Single Enantiomer

Anthonius H. J. Engwerda; Johannes C. J. Mertens; Paul Tinnemans; Hugo Meekes; Floris P. J. T. Rutjes; Elias Vlieg. Angew. Chem. Int. Ed. 2018, 57, 15441–15444. DOI: 10.1002/anie.201808913


539. Synthesis of Elongated Esters from Alkenes

Tomoya Miura; Yuuta Funakoshi; Junki Nakahashi; Daisuke Moriyama; Masahiro Murakami. Angew. Chem. Int. Ed. 2018, 57, 15455–15459. DOI: 10.1002/anie.201809115


540. Hydrogen Atom Transfer Reactions via Photoredox Catalyzed Chlorine Atom Generation

Samantha Rohe; Avery O. Morris; Terry McCallum; Louis Barriault. Angew. Chem. Int. Ed. 2018, 57, 15664–15669. DOI: 10.1002/anie.201810187


541. Amide Effects in C−H Activation: Noncovalent Interactions with L‐Shaped Ligand for meta Borylation of Aromatic Amides

Ranjana Bisht; Md Emdadul Hoque; Buddhadeb Chattopadhyay. Angew. Chem. Int. Ed. 2018, 57, 15762–15766. DOI: 10.1002/anie.201809929


542. Photoredox/Nickel‐Catalyzed Single‐Electron Tsuji–Trost Reaction: Development and Mechanistic Insights

Jennifer K. Matsui; Álvaro Gutiérrez‐Bonet; Madeline Rotella; Rauful Alam; Osvaldo Gutierrez; Gary A. Molander. Angew. Chem. Int. Ed. 2018, 57, 15847–15851. DOI: 10.1002/anie.201809919


543. Palladium‐Catalyzed Intermolecular Arylcarbonylation of Unactivated Alkenes: Incorporation of Bulky Aryl Groups at Room Temperature

Xiang Li; Pinhong Chen; Guosheng Liu. Angew. Chem. Int. Ed. 2018, 57, 15871–15876. DOI: 10.1002/anie.201810405


544. An Electrophilic Bromine Redox Catalysis for the Synthesis of Indole Alkaloid Building Blocks by Selective Aliphatic C−H Amination

Julien Bergès; Belén García; Kilian Muñiz. Angew. Chem. Int. Ed. 2018, 57, 15891–15895. DOI: 10.1002/anie.201808939


545. Platinum‐Catalyzed Desaturation of Lactams, Ketones, and Lactones

Ming Chen; Alexander J. Rago; Guangbin Dong. Angew. Chem. Int. Ed. 2018, 57, 16205–16209. DOI: 10.1002/anie.201811197


546. A Catalytic Cross‐Olefination of Diazo Compounds with Sulfoxonium Ylides

James D. Neuhaus; Adriano Bauer; Alexandre Pinto; Nuno Maulide. Angew. Chem. Int. Ed. 2018, 57, 16215–16218. DOI: 10.1002/anie.201809934


547. Carbonyl–Olefin Cross‐Metathesis Through a Visible‐Light‐Induced 1,3‐Diol Formation and Fragmentation Sequence

Lena Pitzer; Frederik Sandfort; Felix Strieth‐Kalthoff; Frank Glorius. Angew. Chem. Int. Ed. 2018, 57, 16219–16223. DOI: 10.1002/anie.201810221


548. Rapid Structure Determination of Microcrystalline Molecular Compounds Using Electron Diffraction

Tim Gruene; Julian T. C. Wennmacher; Christan Zaubitzer; Julian J. Holstein; Jonas Heidler; Ariane Fecteau‐Lefebvre; Sacha De Carlo; Elisabeth Müller; Kenneth N. Goldie; Irene Regeni; Teng Li; Gustavo Santiso‐Quinones; Gunther Steinfeld; Stephan Handschin; Eric van Genderen; Jeroen A. van Bokhoven; Guido H. Clever; Radosav Pantelic. Angew. Chem. Int. Ed. 2018, 57, 16313–16317. DOI: 10.1002/anie.201811318


549. Enantioselective, Catalytic Vicinal Difluorination of Alkenes

Felix Scheidt; Michael Schäfer; Jérôme C. Sarie; Constantin G. Daniliuc; John J. Molloy; Ryan Gilmour. Angew. Chem. Int. Ed. 2018, 57, 16431–16435. DOI: 10.1002/anie.201810328


550. gem‐Difluorination of Alkenyl N‐methyliminodiacetyl Boronates: Synthesis of α‐ and β‐Difluorinated Alkylborons

Wen‐Xin Lv; Qingjiang Li; Ji‐Lin Li; Zhan Li; E Lin; Dong‐Hang Tan; Yuan‐Hong Cai; Wen‐Xin Fan; Honggen Wang. Angew. Chem. Int. Ed. 2018, 57, 16544–16548. DOI: 10.1002/anie.201810204


551. Bimetallic Rhodium(II)/Indium(III) Relay Catalysis for Tandem Insertion/Asymmetric Claisen Rearrangement

Yushuang Chen; Shunxi Dong; Xi Xu; Xiaohua Liu; Xiaoming Feng. Angew. Chem. Int. Ed. 2018, 57, 16554–16558. DOI: 10.1002/anie.201810410


552. Machine‐Driven Enzymatic Oligosaccharide Synthesis by Using a Peptide Synthesizer

Jiabin Zhang; Congcong Chen; Madhusudhan Reddy Gadi; Christopher Gibbons; Yuxi Guo; Xuefeng Cao; Garrett Edmunds; Shuaishuai Wang; Ding Liu; Jin Yu; Liuqing Wen; Peng G. Wang. Angew. Chem. Int. Ed. 2018, 57, 16638–16642. DOI: 10.1002/anie.201810661


553. Catalytic Radical Process for Enantioselective Amination of C(sp3)−H Bonds

Chaoqun Li; Kai Lang; Hongjian Lu; Yang Hu; Xin Cui; Lukasz Wojtas; X. Peter Zhang. Angew. Chem. Int. Ed. 2018, 57, 16837–16841. DOI: 10.1002/anie.201808923


554. Mild Ring‐Opening 1,3‐Hydroborations of Non‐Activated Cyclopropanes

Di Wang; Xiao‐Song Xue; Kendall N. Houk; Zhuangzhi Shi. Angew. Chem. Int. Ed. 2018, 57, 16861–16865. DOI: 10.1002/anie.201811036


555. Palladium‐Catalyzed Decarbonylative Difluoromethylation of Acid Chlorides at Room Temperature

Fei Pan; Gregory B. Boursalian; Tobias Ritter. Angew. Chem. Int. Ed. 2018, 57, 16871–16876. DOI: 10.1002/anie.201811139


556. Chemoselective Pd‐Catalyzed C‐TeCF3 Coupling of Aryl Iodides

Theresa Sperger; Sinem Guven; Franziska Schoenebeck. Angew. Chem. Int. Ed. 2018, 57, 16903–16906. DOI: 10.1002/anie.201810950


Org. Lett.


558. Iron-Catalyzed C(sp3)–H Acyloxylation of Aryl-2H Azirines with Hypervalent Iodine(III) Reagents

Lulu Wang; Hongji Li; Lei Wang. Org. Lett. 2018, 20, 1663–1666. DOI: 10.1021/acs.orglett.8b00442


559. Radical C–H Arylation of Oxazoles with Aryl Iodides: dppf as an Electron-Transfer Mediator for Cs2CO3

Zhengwei Guo; Man Li; Xue-Qing Mou; Gang He; Xiao-Song Xue; Gong Chen. Org. Lett. 2018, 20, 1684–1687. DOI: 10.1021/acs.orglett.8b00530


560. Development of Planar Chiral Iodoarenes Based on [2.2]Paracyclophane and Their Application in Catalytic Enantioselective Fluorination of β-Ketoesters

Yang Wang; Hang Yuan; Hongfei Lu; Wen-Hua Zheng. Org. Lett. 2018, 20, 2555–2558. DOI: 10.1021/acs.orglett.8b00711


561. Asymmetric Arylation of 2,2,2-Trifluoroacetophenones Catalyzed by Chiral Electrostatically-Enhanced Phosphoric Acids

Jie Ma; Steven R. Kass. Org. Lett. 2018, 20, 2689–2692. DOI: 10.1021/acs.orglett.8b00900


562. Asymmetric Epoxidation of 1,4-Naphthoquinones Catalyzed by Guanidine–Urea Bifunctional Organocatalyst

Masaki Kawaguchi; Katsuhiro Nakano; Keisuke Hosoya; Tatsuya Orihara; Masahiro Yamanaka; Minami Odagi; Kazuo Nagasawa. Org. Lett. 2018, 20, 2811–2815. DOI: 10.1021/acs.orglett.8b00641


563. A Practical and Chemoselective Ammonia-Free Birch Reduction

Peng Lei; Yuxuan Ding; Xiaohe Zhang; Adila Adijiang; Hengzhao Li; Yun Ling; Jie An. Org. Lett. 2018, 20, 3439–3442. DOI: 10.1021/acs.orglett.8b00891


564. Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes

Gregory Beutner; Ronald Carrasquillo; Peng Geng; Yi Hsiao; Eric C. Huang; Jacob Janey; Kishta Katipally; Sergei Kolotuchin; Thomas La Porte; Andrew Lee; Paul Lobben; Federico Lora-Gonzalez; Brendan Mack; Boguslaw Mudryk; Yuping Qiu; Xinhua Qian; Antonio Ramirez; Thomas M. Razler; Thorsten Rosner; Zhongping Shi; Eric Simmons; Jason Stevens; Jianji Wang; Carolyn Wei; Steven R. Wisniewski; Ye Zhu. Org. Lett. 2018, 20, 3736–3740. DOI: 10.1021/acs.orglett.8b01218


565. Enantioselective Cobalt-Catalyzed Sequential Nazarov Cyclization/Electrophilic Fluorination: Access to Chiral α-Fluorocyclopentenones

Heyi Zhang; Biao Cheng; Zhan Lu. Org. Lett. 2018, 20, 4028–4031. DOI: 10.1021/acs.orglett.8b01597


566. Pd-Catalyzed Dearomative Allylation of Benzyl Phosphates

Masaaki Komatsuda; Kei Muto; Junichiro Yamaguchi. Org. Lett. 2018, 20, 4354–4357. DOI: 10.1021/acs.orglett.8b01807


567. Dynamic Kinetic Resolution of Azlactones by a Chiral N,N-Dimethyl-4-aminopyridine Derivative Containing a 1,1′-Binaphthyl Unit: Importance of Amide Groups

Hiroki Mandai; Kohei Hongo; Takuma Fujiwara; Kazuki Fujii; Koichi Mitsudo; Seiji Suga. Org. Lett. 2018, 20, 4811–4814. DOI: 10.1021/acs.orglett.8b01960


568. GaCl3-Catalyzed Ring-Opening Carbonyl–Olefin Metathesis

Haley Albright; Hannah L. Vonesh; Marc R. Becker; Brandon W. Alexander; Jacob R. Ludwig; Ren A. Wiscons; Corinna S. Schindler. Org. Lett. 2018, 20, 4954–4958. DOI: 10.1021/acs.orglett.8b02086


569. A Strategy to Aminate Pyridines, Diazines, and Pharmaceuticals via Heterocyclic Phosphonium Salts

Chirag Patel; Margaret Mohnike; Michael C. Hilton; Andrew McNally. Org. Lett. 2018, 20, 2607–2610. DOI: 10.1021/acs.orglett.8b00813


570. Nucleophilic Reactivities of Bleach Reagents

Robert J. Mayer; Armin R. Ofial. Org. Lett. 2018, 20, 2816–2820. DOI: 10.1021/acs.orglett.8b00645


571. Decarbonylative Methylation of Aromatic Esters by a Nickel Catalyst

Toshimasa Okita; Kei Muto; Junichiro Yamaguchi. Org. Lett. 2018, 20, 3132–3135. DOI: 10.1021/acs.orglett.8b01233


572. Dicyclopentyl Dithiosquarate as an Intermediate for the Synthesis of Thiosquaramides

Michael Rombola; Viresh H. Rawal. Org. Lett. 2018, 20, 514–517. DOI: 10.1021/acs.orglett.7b03549


573. Catalytically Enantioselective Synthesis of Acyclic α-Tertiary Amines through Desymmetrization of 2-Substituted 2-Nitro-1,3-diols

Shan-Shui Meng</a>; , ; ; Wu-Bang Tang; Wen-Hua Zheng. Org. Lett. 2018, 20, 518–521. DOI: 10.1021/acs.orglett.7b03581


574. Chemo-, Regio-, and Enantioselective Rhodium-Catalyzed Allylation of Triazoles with Internal Alkynes and Terminal Allenes

Dino Berthold; Bernhard Breit. Org. Lett. 2018, 20, 598–601. DOI: 10.1021/acs.orglett.7b03708


575. Catalytic Oligopeptide Synthesis

Zijian Liu; Hidetoshi Noda; Masakatsu Shibasaki; Naoya Kumagai. Org. Lett. 2018, 20, 612–615. DOI: 10.1021/acs.orglett.7b03735


576. Enantioselective Trapping of Oxonium Ylides by 3-Hydroxyisoindolinones via a Formal SN1 Pathway for Construction of Contiguous Quaternary Stereocenters

Zhenghui Kang; Dan Zhang; Jiayi Shou; Wenhao Hu. Org. Lett. 2018, 20, 983–986. DOI: 10.1021/acs.orglett.7b03916


577. Asymmetric Construction of Fluoroalkyl Tertiary Alcohols through a Three-Component Reaction of (Bpin)2, 1,3-Enynes, and Fluoroalkyl Ketones Catalyzed by a Copper(I) Complex

Xu-Cheng Gan; Qi Zhang; Xue-Shun Jia; Liang Yin. Org. Lett. 2018, 20, 1070–1073. DOI: 10.1021/acs.orglett.7b04039


578. Synthetic Approach to Benzocyclobutenones Using Visible Light and a Phosphonate Auxiliary

Takaaki Yano; Tairin Kawasaki; Tatsuya Yuhki; Naoki Ishida; Masahiro Murakami. Org. Lett. 2018, 20, 1224–1227. DOI: 10.1021/acs.orglett.8b00160


579. Oxycyanation of Vinyl Ethers with 2,2,6,6-Tetramethyl-N-oxopiperidinium Enabled by Electron Donor–Acceptor Complex

Jia-Li Liu; Ze-Fan Zhu; Feng Liu. Org. Lett. 2018, 20, 720–723. DOI: 10.1021/acs.orglett.7b03858


580. Synthesis of 5-C-Methylated d-Mannose, d-Galactose, l-Gulose, and l-Altrose and Their Structural Elucidation by NMR Spectroscopy

Christoph Köllmann; Peter G. Jones; Daniel B. Werz. Org. Lett. 2018, 20, 1220–1223. DOI: 10.1021/acs.orglett.8b00144


581. Tetramethyl Orthosilicate (TMOS) as a Reagent for Direct Amidation of Carboxylic Acids

D. Christopher Braddock; Paul D. Lickiss; Ben C. Rowley; David Pugh; Teresa Purnomo; Gajan Santhakumar; Steven J. Fussell. Org. Lett. 2018, 20, 950–953. DOI: 10.1021/acs.orglett.7b03841


582. Enamines as Surrogates of Alkene Carbanions for the Reductive Alkenylation of Secondary Amides: An Approach to Allylamines

Ai-E Wang; Cun-Cun Yu; Ting-Ting Chen; Yong-Peng Liu; Pei-Qiang Huang. Org. Lett. 2018, 20, 999–1002. DOI: 10.1021/acs.orglett.7b03943


583. Dicyclopentyl Dithiosquarate as an Intermediate for the Synthesis of Thiosquaramides

Michael Rombola; Viresh H. Rawal. Org. Lett. 2018, 20, 514–517. DOI: 10.1021/acs.orglett.7b03549


584. Catalytically Enantioselective Synthesis of Acyclic α-Tertiary Amines through Desymmetrization of 2-Substituted 2-Nitro-1,3-diols

Shan-Shui Meng</a>; , ; ; Wu-Bang Tang; Wen-Hua Zheng. Org. Lett. 2018, 20, 518–521. DOI: 10.1021/acs.orglett.7b03581


585. Chemo-, Regio-, and Enantioselective Rhodium-Catalyzed Allylation of Triazoles with Internal Alkynes and Terminal Allenes

Dino Berthold; Bernhard Breit. Org. Lett. 2018, 20, 598–601. DOI: 10.1021/acs.orglett.7b03708


586. Catalytic Oligopeptide Synthesis

Zijian Liu; Hidetoshi Noda; Masakatsu Shibasaki; Naoya Kumagai. Org. Lett. 2018, 20, 612–615. DOI: 10.1021/acs.orglett.7b03735


587. Enantioselective Trapping of Oxonium Ylides by 3-Hydroxyisoindolinones via a Formal SN1 Pathway for Construction of Contiguous Quaternary Stereocenters

Zhenghui Kang; Dan Zhang; Jiayi Shou; Wenhao Hu. Org. Lett. 2018, 20, 983–986. DOI: 10.1021/acs.orglett.7b03916


588. Asymmetric Construction of Fluoroalkyl Tertiary Alcohols through a Three-Component Reaction of (Bpin)2, 1,3-Enynes, and Fluoroalkyl Ketones Catalyzed by a Copper(I) Complex

Xu-Cheng Gan; Qi Zhang; Xue-Shun Jia; Liang Yin. Org. Lett. 2018, 20, 1070–1073. DOI: 10.1021/acs.orglett.7b04039


589. Synthetic Approach to Benzocyclobutenones Using Visible Light and a Phosphonate Auxiliary

Takaaki Yano; Tairin Kawasaki; Tatsuya Yuhki; Naoki Ishida; Masahiro Murakami. Org. Lett. 2018, 20, 1224–1227. DOI: 10.1021/acs.orglett.8b00160


590. An Unprecedented (Semi)Favorskii Rearrangement. Evidence for the 2-(Acyloxy)cyclopropanones

Santu Sadhukhan; Beeraiah Baire. Org. Lett. 2018, 20, 1748–1751. DOI: 10.1021/acs.orglett.8b00218


591. Kinetic Resolution of β-Hydroxy Carbonyl Compounds via Enantioselective Dehydration Using a Cation-Binding Catalyst: Facile Access to Enantiopure Chiral Aldols

Sushovan Paladhi; In-Soo Hwang; Eun Jeong Yoo; Do Hyun Ryu; Choong Eui Song. Org. Lett. 2018, 20, 2003–2006. DOI: 10.1021/acs.orglett.8b00547


592. A Synthetic Route to Sodium α-Aminoalkanesulfinates and Their Application in the Generation of α-Aminoalkyl Radicals for Radical Addition Reactions

Ryu Sakamoto; Hiroyuki Takada; Keiji Maruoka. Org. Lett. 2018, 20, 2080–2083. DOI: 10.1021/acs.orglett.8b00621


593. Brønsted-Acid-Promoted Rh-Catalyzed Asymmetric Hydrogenation of N-Unprotected Indoles: A Cocatalysis of Transition Metal and Anion Binding

Jialin Wen; Xiangru Fan; Renchang Tan; Hui-Chun Chien; Qinghai Zhou; Lung Wa Chung; Xumu Zhang. Org. Lett. 2018, 20, 2143–2147. DOI: 10.1021/acs.orglett.8b00312


594. Multicomponent Oxidative Trifluoromethylation of Alkynes with Photoredox Catalysis: Synthesis of α-Trifluoromethyl Ketones

Yashwardhan R. Malpani; Bishyajit Kumar Biswas; Hong Sik Han; Young-Sik Jung; Soo Bong Han. Org. Lett. 2018, 20, 1693–1697. DOI: 10.1021/acs.orglett.8b00410


595. Photoredox-Catalyzed Trifluoromethylative Intramolecular Cyclization: Synthesis of CF3-Containing Heterocyclic Compounds

Hong Sik Han; Eun Hye Oh; Young-Sik Jung; Soo Bong Han. Org. Lett. 2018, 20, 1698–1702. DOI: 10.1021/acs.orglett.8b00648


596. Primary Aminothiourea-Catalyzed Enantioselective Synthesis of Rauhut–Currier Adducts of 3-Arylcyclohexenone with a Tethered Enone on the Aryl Moiety at the Ortho-Position

Sanjay Maity; Suman Sar; Prasanta Ghorai. Org. Lett. 2018, 20, 1707–1711. DOI: 10.1021/acs.orglett.7b03959


597. Stereospecific Decarboxylative Benzylation of Enolates: Development and Mechanistic Insight

Tian-Ren Li; Mary L. Maliszewski; Wen-Jing Xiao; Jon A. Tunge. Org. Lett. 2018, 20, 1730–1734. DOI: 10.1021/acs.orglett.8b00169


598. Catalytic Enantioselective Birch–Heck Sequence for the Synthesis of Tricyclic Structures with All-Carbon Quaternary Stereocenters

Andrew T. Krasley; William P. Malachowski; Hannah M. Terz; Sabrina Tran Tien. Org. Lett. 2018, 20, 1740–1743. DOI: 10.1021/acs.orglett.8b00196


599. Copper-Catalyzed Diastereo- and Enantioselective Borylative Cyclization: Synthesis of Enantioenriched 2,3-Disubstituted Indolines

Ge Zhang; Aijie Cang; Ying Wang; Yanfei Li; Guoxing Xu; Qian Zhang; Tao Xiong; Qian Zhang. Org. Lett. 2018, 20, 1798–1801. DOI: 10.1021/acs.orglett.8b00246


600. Photochemical Nickel-Catalyzed Reductive Migratory Cross-Coupling of Alkyl Bromides with Aryl Bromides

Long Peng; Zheqi Li; Guoyin Yin. Org. Lett. 2018, 20, 1880–1883. DOI: 10.1021/acs.orglett.8b00413


601. Access to Quaternary Stereogenic Centers via Rhodium(III)-Catalyzed Annulations between 2-Phenylindoles and Ketenes

Xifa Yang; Yunyun Li; Lingheng Kong; Xingwei Li. Org. Lett. 2018, 20, 1957–1960. DOI: 10.1021/acs.orglett.8b00497


602. Copper(II)-Catalyzed Tandem Decarboxylative Michael/Aldol Reactions Leading to the Formation of Functionalized Cyclohexenones

Jeonghyo Lee; Sibin Wang; Miranda Callahan; Pavel Nagorny. Org. Lett. 2018, 20, 2067–2070. DOI: 10.1021/acs.orglett.8b00607


603. Harnessing the β-Silicon Effect for Regioselective and Stereoselective Rhodium(II)-Catalyzed C–H Functionalization by Donor/Acceptor Carbenes Derived from 1-Sulfonyl-1,2,3-triazoles

Zachary J. Garlets; Huw M. L. Davies. Org. Lett. 2018, 20, 2168–2171. DOI: 10.1021/acs.orglett.8b00427


604. Asymmetric Construction of Remote Vicinal Quaternary and Tertiary Stereocenters via Direct Doubly Vinylogous Michael Addition

Subhrajit Rout; Harshit Joshi; Vinod K. Singh. Org. Lett. 2018, 20, 2199–2203. DOI: 10.1021/acs.orglett.8b00493


605. Radical Borylative Cyclization of 1,6-Dienes: Synthesis of Boron-Substituted Six-Membered Heterocycles and Carbocycles

Jing Qi; Feng-Lian Zhang; Yun-Shuai Huang; Ai-Qing Xu; Shi-Chao Ren; Zhen-Yu Yi; Yi-Feng Wang. Org. Lett. 2018, 20, 2360–2364. DOI: 10.1021/acs.orglett.8b00694


606. Diastereoselective Copper-Mediated Cross-Couplings between Stereodefined Secondary Alkylcoppers with Bromoalkynes

Juri Skotnitzki; Varvara Morozova; Paul Knochel. Org. Lett. 2018, 20, 2365–2368. DOI: 10.1021/acs.orglett.8b00699


607. Stereoselective Synthesis of Optically Pure 2-Amino-2′-hydroxy-1,1′-binaphthyls

Hagit Forkosh; Vlada Vershinin; Hagai Reiss; Doron Pappo. Org. Lett. 2018, 20, 2459–2463. DOI: 10.1021/acs.orglett.8b00800


608. Enantioselective Synthesis of α-(Hetero)aryl Piperidines through Asymmetric Hydrogenation of Pyridinium Salts and Its Mechanistic Insights

Bo Qu; Hari P. R. Mangunuru; Sergei Tcyrulnikov; Daniel Rivalti; Olga V. Zatolochnaya; Dmitry Kurouski; Suttipol Radomkit; Soumik Biswas; Shuklendu Karyakarte; Keith R. Fandrick; Joshua D. Sieber; Sonia Rodriguez; Jean-Nicolas Desrosiers; Nizar Haddad; Keith McKellop; Scott Pennino; Heewon Lee; Nathan K. Yee; Jinhua J. Song; Marisa C. Kozlowski; Chris H. Senanayake. Org. Lett. 2018, 20, 1333–1337. DOI: 10.1021/acs.orglett.8b00067


609. Disulfide-Bridged Peptides That Mediate Enantioselective Cycloadditions through Thiyl Radical Catalysis

Jonathan M. Ryss; Amanda K. Turek; Scott J. Miller. Org. Lett. 2018, 20, 1621–1625. DOI: 10.1021/acs.orglett.8b00364


610. Visible-Light-Mediated Synthesis of Ketones by the Oxidative Alkylation of Styrenes

Adrian Tlahuext-Aca; R. Aleyda Garza-Sanchez; Michael Schäfer; Frank Glorius. Org. Lett. 2018, 20, 1546–1549. DOI: 10.1021/acs.orglett.8b00272


611. Base-Catalyzed Borylation/B–O Elimination of Propynols and B2pin2 Delivering Tetrasubstituted Alkenylboronates

Zhijie Kuang; Haohua Chen; Jianxiang Yan; Kai Yang; Yu Lan; Qiuling Song. Org. Lett. 2018, 20, 5153–5157. DOI: 10.1021/acs.orglett.8b02077


612. Asymmetric Synthesis of Remote Quaternary Centers by Copper-Catalyzed Desymmetrization: An Enantioselective Total Synthesis of (+)-Mesembrine

Apparao Bokka; James X. Mao; John Hartung; Steven R. Martinez; Justin A. Simanis; Kwangho Nam; Junha Jeon; Xiaoqiang Shen. Org. Lett. 2018, 20, 5158–5162. DOI: 10.1021/acs.orglett.8b02084


613. Acid-Catalyzed O-Glycosylation with Stable Thioglycoside Donors

Kristina D. Lacey; Rashanique D. Quarels; Shaofu Du; Ashley Fulton; Nicholas J. Reid; Austin Firesheets; Justin R. Ragains. Org. Lett. 2018, 20, 5181–5185. DOI: 10.1021/acs.orglett.8b02125


614. Glycosylation of a Ketone with an O-Glycosyl Trichloroacetimidate Provides an Enol Glycoside

Xianglai Liu; Sumei Ren; Qi Gao; Chun Hu; Yingxia Li; Ning Ding. Org. Lett. 2018, 20, 5186–5189. DOI: 10.1021/acs.orglett.8b02126


615. Enantioselective Reaction between 2-(Cyanomethyl)azaarenes and N-Boc-amino Sulfones

Kezhou Wang; Chao Chen; Xihong Liu; Dan Li; Tianyu Peng; Xin Liu; Dongxu Yang; Linqing Wang. Org. Lett. 2018, 20, 5260–5263. DOI: 10.1021/acs.orglett.8b02205


616. Organocatalytic Enantioselective Cycloetherifications Using a Cooperative Cation-Binding Catalyst

Amol P. Jadhav; Jeong-A Oh; In-Soo Hwang; Hailong Yan; Choong Eui Song. Org. Lett. 2018, 20, 5319–5322. DOI: 10.1021/acs.orglett.8b02240


617. Synthesis of 1,2-Oxazinanes via Hydrogen Bond Mediated [3 + 3] Cycloaddition Reactions of Oxyallyl Cations with Nitrones

Lingbowei Hu; Michael Rombola; Viresh H. Rawal. Org. Lett. 2018, 20, 5384–5388. DOI: 10.1021/acs.orglett.8b02301


618. Synthesis of Chiral Six-Membered Carbocyclic Purine Nucleosides via Organocatalytic Enantioselective [3 + 3] Annulation

Ke-Xin Huang; Ming-Sheng Xie; Qi-Ying Zhang; Hong-Ying Niu; Gui-Rong Qu; Hai-Ming Guo. Org. Lett. 2018, 20, 5398–5401. DOI: 10.1021/acs.orglett.8b02309


619. Phosphine-Catalyzed Formal Oxa-[4 + 2] Annulation Employing Nitroethylene and Enones: Enantioselective Synthesis of Dihydropyrans

Zhichao Jin; Huanzhen Ni; Bo Zhou; Wenrui Zheng; Yixin Lu. Org. Lett. 2018, 20, 5515–5518. DOI: 10.1021/acs.orglett.8b02519


620. Cinchona–Diaminomethylenemalononitrile Organocatalyst for the Highly Enantioselective Hydrophosphonylation of Ketones and Enones

Ryoga Arai; Shin-ichi Hirashima; Junko Kondo; Kosuke Nakashima; Yuji Koseki; Tsuyoshi Miura. Org. Lett. 2018, 20, 5569–5572. DOI: 10.1021/acs.orglett.8b02241


621. Rh-Catalyzed Asymmetric Hydrogenation of β-Substituted-β-thio-α,β-unsaturated Esters: Expeditious Access to Chiral Organic Sulfides

Gang Liu; Zhengyu Han; Xiu-Qin Dong; Xumu Zhang. Org. Lett. 2018, 20, 5636–5639. DOI: 10.1021/acs.orglett.8b02339


622. Mild Dirhodium(II)-Catalyzed Chemo- and Regioselective Azidation of Arenes

Yi Wang; Zaixiang Fang; Xiaochuan Chen; Yuanhua Wang. Org. Lett. 2018, 20, 5732–5736. DOI: 10.1021/acs.orglett.8b02446


623. Oxidative Decarboxylation Enables Chemoselective, Racemization-Free Esterification: Coupling of α-Ketoacids and Alcohols Mediated by Hypervalent Iodine(III)

Takeshi Nanjo; Natsuki Kato; Yoshiji Takemoto. Org. Lett. 2018, 20, 5766–5769. DOI: 10.1021/acs.orglett.8b02466


624. A Protocol To Transform Sulfones into Nitrones and Aldehydes

Eduardo Rodrigo; Inés Alonso; M. Belén Cid. Org. Lett. 2018, 20, 5789–5793. DOI: 10.1021/acs.orglett.8b02483


625. Dearomative Dienolate-Mediated Catalysis: A Remote Activation Strategy for Asymmetric Functionalization of Benzylic C–H Bonds of Heteroaryl Aldehydes

Yang Wang; Jun-Bing Lin; Ji-Kang Xie; Hong Lu; Xiu-Qin Hu; Peng-Fei Xu. Org. Lett. 2018, 20, 5835–5839. DOI: 10.1021/acs.orglett.8b02523


626. Combining Organocatalysis and Iodine Catalysis: One-Pot Sequential Catalytic Synthesis of Chiral Spirodihydrobenzofuran Pyrazolones and Spirodihydrobenzofuran Oxindoles

Cheng-Ke Tang; Zhan-Yu Zhou; Ai-Bao Xia; Liang Bai; Jie Liu; Dan-Qian Xu; Zhen-Yuan Xu. Org. Lett. 2018, 20, 5840–5844. DOI: 10.1021/acs.orglett.8b02525


627. Total Synthesis of Trisaccharide Repeating Unit of O-Specific Polysaccharide of Pseudomonas fluorescens BIM B-582

Archanamayee Behera; Diksha Rai; Divya Kushwaha; Suvarn S. Kulkarni. Org. Lett. 2018, 20, 5956–5959. DOI: 10.1021/acs.orglett.8b02669


628. A Ring Contraction of 2,3-Di-O-Silylated Thiopyranosides To Give Thiofuranosides under Mildly Acidic Conditions

Polina I. Abronina; Nelly N. Malysheva; Veronika V. Litvinenko; Alexander I. Zinin; Natalya G. Kolotyrkina; Leonid O. Kononov. Org. Lett. 2018, 20, 6051–6054. DOI: 10.1021/acs.orglett.8b02424


629. Chiral Aniline Synthesis via Stereospecific C(sp3)–C(sp2) Coupling of Boronic Esters with Aryl Hydrazines

Venkataraman Ganesh; Adam Noble; Varinder K. Aggarwal. Org. Lett. 2018, 20, 6144–6147. DOI: 10.1021/acs.orglett.8b02615


630. Design and Synthesis of 2-Acetamido-2,3-dideoxythiodisaccharides via Diastereoselective Conjugate Addition to Sugar Enone O-Acetyl Oximes. Galactosidase Inhibition Studies

Lucas Dada; Verónica E. Manzano; Oscar Varela. Org. Lett. 2018, 20, 6225–6228. DOI: 10.1021/acs.orglett.8b02692


631. Organocatalytic Enantioselective 1,3-Difunctionalizations of Morita–Baylis–Hillman Carbonates

Zhi-Chao Chen; Peng Chen; Zhi Chen; Qin Ouyang; Hua-Ping Liang; Wei Du; Ying-Chun Chen. Org. Lett. 2018, 20, 6279–6283. DOI: 10.1021/acs.orglett.8b02764


632. N-Arylation of DABCO with Diaryliodonium Salts: General Synthesis of N-Aryl-DABCO Salts as Precursors for 1,4-Disubstituted Piperazines

Dmitry I. Bugaenko; Marina A. Yurovskaya; Alexander V. Karchava. Org. Lett. 2018, 20, 6389–6393. DOI: 10.1021/acs.orglett.8b02676


633. Thiourea-Catalyzed Enantioselective Malonate Addition onto 3-Sulfonyl-3′-indolyl-2-oxindoles: Formal Total Syntheses of (−)-Chimonanthine, (−)-Folicanthine, and (+)-Calycanthine

K. Naresh Babu; Avishek Roy; Manvendra Singh; Alakesh Bisai. Org. Lett. 2018, 20, 6327–6331. DOI: 10.1021/acs.orglett.8b02327


634. Stereocontrolled Nucleophilic Fluorination at the Tertiary sp3-Carbon Center for Enantiopure Synthesis of 3-Fluorooxindoles

Saumen Hajra; Atanu Hazra; Paltu Mandal. Org. Lett. 2018, 20, 6471–6475. DOI: 10.1021/acs.orglett.8b02777


635. Highly (Z)-Diastereoselective Synthesis of Trifluoromethylated exo-Glycals via Photoredox and Copper Catalysis

Christophe J.-M. Frédéric; Jérôme Cornil; Mathilde Vandamme; Lidia Dumitrescu; Abdellatif Tikad; Raphaël Robiette; Stéphane P. Vincent. Org. Lett. 2018, 20, 6769–6773. DOI: 10.1021/acs.orglett.8b02891


636. Achieving Enantioselectivity in Difficult Cyclohexa-1,3-diene Diels–Alder Reactions with Sulfur-Stabilized Silicon Cations as Lewis Acid Catalysts

Polina Shaykhutdinova; Martin Oestreich. Org. Lett. 2018, 20, 7029–7033. DOI: 10.1021/acs.orglett.8b02945


637. Access to α,γ-Diamino Diacid Derivatives via Organocatalytic Asymmetric 1,4-Addition of Azlactones and Dehydroalanines

Junxian Yang; Wangsheng Sun; Zeyuan He; Changjun Yu; Guangjun Bao; Yiping Li; Yuyang Liu; Liang Hong; Rui Wang. Org. Lett. 2018, 20, 7080–7084. DOI: 10.1021/acs.orglett.8b03020


638. Synthesis of Quaternary α-Fluorinated α-Amino Acid Derivatives via Coordinating Cu(II) Catalytic α-C(sp3)–H Direct Fluorination

Qiang Wei; Yao Ma; Li Li; Qingfei Liu; Zijie Liu; Gang Liu. Org. Lett. 2018, 20, 7100–7103. DOI: 10.1021/acs.orglett.8b03044


639. Catalytic Asymmetric Hydrophosphination of ortho-Quinone Methides

Xiu Gu; Hao Yuan; Jun Jiang; Yi Wu; Wen-Ju Bai. Org. Lett. 2018, 20, 7229–7233. DOI: 10.1021/acs.orglett.8b03158


640. FeCl3 as an Ion-Pairing Lewis Acid Catalyst. Formation of Highly Lewis Acidic FeCl2+ and Thermodynamically Stable FeCl4 To Catalyze the Aza-Diels–Alder Reaction with High Turnover Frequency

Rei Tomifuji; Kazuki Maeda; Toshifumi Takahashi; Takuya Kurahashi; Seijiro Matsubara. Org. Lett. 2018, 20, 7474–7477. DOI: 10.1021/acs.orglett.8b03249


641. Unraveling and Manipulating the Stereospecific Retro-Aldol Reaction in the Organocatalytic Asymmetric Aldol Reaction of Isatin and Cyclohexanone

Jing Wang; Zhi-Xiong Deng; Chao-Ming Wang; Peng-Ju Xia; Jun-An Xiao; Hao-Yue Xiang; Xiao-Qing Chen; Hua Yang. Org. Lett. 2018, 20, 7535–7538. DOI: 10.1021/acs.orglett.8b03292


642. Organocatalytic Enantioselective Synthesis of α-Fluoro-β-amino Acid Derivatives

Matthew R. Straub; Vladimir B. Birman. Org. Lett. 2018, 20, 7550–7553. DOI: 10.1021/acs.orglett.8b03297


643. Synthesis of the Non-Reducing Hexasaccharide Fragment of Saccharomicin B

Manas Jana; Clay S. Bennett. Org. Lett. 2018, 20, 7598–7602. DOI: 10.1021/acs.orglett.8b03333


644. Visible-Light-Enabled Oxidative Alkylation of Unactivated Alkenes with Dimethyl Sulfoxide through Concomitant 1,2-Aryl Migration

Maojian Lu; Honggui Qin; Zhaowei Lin; Mingqiang Huang; Wen Weng; Shunyou Cai. Org. Lett. 2018, 20, 7611–7615. DOI: 10.1021/acs.orglett.8b03340


645. Organocatalytic Asymmetric Atroposelective Construction of Axially Chiral 1,4-Distyrene 2,3-Naphthalene Diols

Shan Li; Da Xu; Fangli Hu; Dongmei Li; Wenling Qin; Hailong Yan. Org. Lett. 2018, 20, 7665–7669. DOI: 10.1021/acs.orglett.8b03398


646. Metal-Free Direct Construction of 2-(Oxazol-5-yl)phenols from N-Phenoxyamides and Alkynylbenziodoxolones via Sequential [3,3]-Rearrangement/Cyclization

Ming Li; Jia-Hui Wang; Wei Li; Li-Rong Wen. Org. Lett. 2018, 20, 7694–7698. DOI: 10.1021/acs.orglett.8b03427


647. Catalyst- and Substituent-Controlled Switching of Chemoselectivity for the Enantioselective Synthesis of Fully Substituted Cyclobutane Derivatives via 2 + 2 Annulation of Vinylogous Ketone Enolates and Nitroalkene

Pavan Sudheer Akula; Bor-Cherng Hong; Gene-Hsiang Lee. Org. Lett. 2018, 20, 7835–7839. DOI: 10.1021/acs.orglett.8b03335


648. Enantioselective [3 + 2] Cycloaddition Reaction of Ethynylethylene Carbonates with Malononitrile Enabled by Organo/Metal Cooperative Catalysis

Yu-Chen Zhang; Bo-Wen Zhang; Rui-Long Geng; Jin Song. Org. Lett. 2018, 20, 7907–7911. DOI: 10.1021/acs.orglett.8b03454


649. Synthesis of 2-Quinolinones via a Hypervalent Iodine(III)-Mediated Intramolecular Decarboxylative Heck-Type Reaction at Room Temperature

Huaqiang Fan; Peng Pan; Yongqiang Zhang; Wei Wang. Org. Lett. 2018, 20, 7929–7932. DOI: 10.1021/acs.orglett.8b03503


650. Intermolecular Acetoxyaminoalkylation of α-Diazo Amides with (Diacetoxyiodo)benzene and Amines

Nadine Döben; Hong Yan; Marvin Kischkewitz; Jincheng Mao; Armido Studer. Org. Lett. 2018, 20, 7933–7936. DOI: 10.1021/acs.orglett.8b03504


651. Direct Primary Amination of Alkylmetals with NH-Oxaziridine

Nicole Erin Behnke; Russell Kielawa; Doo-Hyun Kwon; Daniel H. Ess; László Kürti. Org. Lett. 2018, 20, 8064–8068. DOI: 10.1021/acs.orglett.8b03734


652. Catalytic Geminal Difluorination of Styrenes for the Construction of Fluorine-rich Bioisosteres

Felix Scheidt; Jessica Neufeld; Michael Schäfer; Christian Thiehoff; Ryan Gilmour. Org. Lett. 2018, 20, 8073–8076. DOI: 10.1021/acs.orglett.8b03794


Chem. Sci./Chem. Commun.


653. Absolute and relative facial selectivities in organocatalytic asymmetric chlorocyclization reactions

Nastaran Salehi Marzijarani; Roozbeh Yousefi; Arvind Jaganathan; Kumar Dilip Ashtekar; James E. Jackson; Babak Borhan. Chem. Sci. 2018, 9, 2898–2908. DOI: 10.1039/c7sc04430e


654. Unusual mechanisms in Claisen rearrangements: an ionic fragmentation leading to a meta-selective rearrangement

Boris Maryasin; Dainis Kaldre; Renan Galaverna; Immo Klose; Stefan Ruider; Martina Drescher; Hanspeter Kählig; Leticia González; Marcos N. Eberlin; Igor D. Jurberg; Nuno Maulide. Chem. Sci. 2018, 9, 4124–4131. DOI: 10.1039/c7sc04736c


655. Nontrigonal constraint enhances 1,2-addition reactivity of phosphazenes

Yi-Chun Lin; James C. Gilhula; Alexander T. Radosevich. Chem. Sci. 2018, 9, 4338–4347. DOI: 10.1039/c8sc00929e


656. β C–H di-halogenation via iterative hydrogen atom transfer

Ethan A. Wappes; Avassaya Vanitcha; David A. Nagib. Chem. Sci. 2018, 9, 4500–4504. DOI: 10.1039/c8sc01214h


657. A chiral nickel DBFOX complex as a bifunctional catalyst for visible-light-promoted asymmetric photoredox reactions

Xiang Shen; Yanjun Li; Zhaorui Wen; Shi Cao; Xinyi Hou; Lei Gong. Chem. Sci. 2018, 9, 4562–4568. DOI: 10.1039/c8sc01219a


658. Enantioselective synthesis of amines by combining photoredox and enzymatic catalysis in a cyclic reaction network

Xingwei Guo; Yasunori Okamoto; Mirjam R. Schreier; Thomas R. Ward; Oliver S. Wenger. Chem. Sci. 2018, 9, 5052–5056. DOI: 10.1039/c8sc01561a


659. Facile synthesis of α-aminoboronic acids from amines and potassium acyltrifluoroborates (KATs) via trifluoroborate-iminiums (TIMs)

Tomoya Shiro; Anne Schuhmacher; Moritz K. Jackl; Jeffrey W. Bode. Chem. Sci. 2018, 9, 5191–5196. DOI: 10.1039/c8sc01486h


660. Fine-tuned organic photoredox catalysts for fragmentation-alkynylation cascades of cyclic oxime ethers

Franck Le Vaillant; Marion Garreau; Stefano Nicolai; Ganna Gryn'ova; Clemence Corminboeuf; Jerome Waser. Chem. Sci. 2018, 9, 5883–5889. DOI: 10.1039/c8sc01818a


661. Site-selective 18F fluorination of unactivated C–H bonds mediated by a manganese porphyrin

Wei Liu; Xiongyi Huang; Michael S. Placzek; Shane W. Krska; Paul McQuade; Jacob M. Hooker; John T. Groves. Chem. Sci. 2018, 9, 1168–1172. DOI: 10.1039/c7sc04545j


662. Alkylative kinetic resolution of vicinal diols under phase-transfer conditions: a chiral ammonium borinate catalysis

Martin Pawliczek; Takuya Hashimoto; Keiji Maruoka. Chem. Sci. 2018, 9, 1231–1235. DOI: 10.1039/c7sc04854h


663. Synthesis and kinetic resolution of substituted tetrahydroquinolines by lithiation then electrophilic quench

Nicholas Carter; Xiabing Li; Lewis Reavey; Anthony J. H. M. Meijer; Iain Coldham. Chem. Sci. 2018, 9, 1352–1357. DOI: 10.1039/c7sc04435f


664. Stereoselective construction of sterically hindered oxaspirocycles via chiral bidentate directing group-mediated C(sp3)–O bond formation

Yechan Kim; Seoung-Tae Kim; Dahye Kang; Te-ik Sohn; Eunyoung Jang; Mu-Hyun Baik; Sungwoo Hong. Chem. Sci. 2018, 9, 1473–1480. DOI: 10.1039/c7sc04691j


665. Catalytic asymmetric total syntheses of myrtucommuacetalone, myrtucommuacetalone B, and callistrilones A, C, D and E

Min-Jing Cheng; Jia-Qing Cao; Xin-Yi Yang; Li-Ping Zhong; Li-Jun Hu; Xi Lu; Bao-Long Hou; Ya-Jian Hu; Ying Wang; Xue-Fu You; Lei Wang; Wen-Cai Ye; Chuang-Chuang Li. Chem. Sci. 2018, 9, 1488–1495. DOI: 10.1039/c7sc04672c


666. Exploring the mechanism of the Pd-catalyzed spirocyclization reaction: a combined DFT and experimental study

Ivan Franzoni; Hyung Yoon; José-Antonio García-López; Amalia Isabel Poblador-Bahamonde; Mark Lautens. Chem. Sci. 2018, 9, 1496–1509. DOI: 10.1039/c7sc04709f


667. Regioselective Simmons–Smith-type cyclopropanations of polyalkenes enabled by transition metal catalysis

Jacob Werth; Christopher Uyeda. Chem. Sci. 2018, 9, 1604–1609. DOI: 10.1039/c7sc04861k


668. Calcium(II)-catalyzed enantioselective conjugate additions of amines

Brice E. Uno; Rachel D. Dicken; Louis R. Redfern; Charlotte M. Stern; Greg G. Krzywicki; Karl A. Scheidt. Chem. Sci. 2018, 9, 1634–1639. DOI: 10.1039/c7sc05205g


669. Rhodium(I)-catalyzed asymmetric [4 + 2] cycloaddition reactions of 2-alkylenecyclobutanols with cyclic enones through C–C bond cleavage: efficient access to trans-bicyclic compounds

Xinxin Zheng; Rui Guo; Guozhu Zhang; Dayong Zhang. Chem. Sci. 2018, 9, 1873–1877. DOI: 10.1039/c7sc04784c


670. A catalytic highly enantioselective allene approach to oxazolines

Hongwen Luo; Zheng Yang; Weilong Lin; Yangguangyan Zheng; Shengming Ma. Chem. Sci. 2018, 9, 1964–1969. DOI: 10.1039/c7sc04079b


671. Diastereo- and enantioselective additions of α-nitro esters to imines for anti-α,β-diamino acid synthesis with α-alkyl-substitution

Daniel J. Sprague; Anand Singh; Jeffrey N. Johnston. Chem. Sci. 2018, 9, 2336–2339. DOI: 10.1039/c7sc05176j


672. The mechanism of directed Ni(II)-catalyzed C–H iodination with molecular iodine

Brandon E. Haines; Jin-Quan Yu; Djamaladdin G. Musaev. Chem. Sci. 2018, 9, 1144–1154. DOI: 10.1039/c7sc04604a


673. Synthesis and kinetic resolution of substituted tetrahydroquinolines by lithiation then electrophilic quench

Nicholas Carter; Xiabing Li; Lewis Reavey; Anthony J. H. M. Meijer; Iain Coldham. Chem. Sci. 2018, 9, 1352–1357. DOI: 10.1039/c7sc04435f


674. Stereoselective construction of sterically hindered oxaspirocycles via chiral bidentate directing group-mediated C(sp3)–O bond formation

Yechan Kim; Seoung-Tae Kim; Dahye Kang; Te-ik Sohn; Eunyoung Jang; Mu-Hyun Baik; Sungwoo Hong. Chem. Sci. 2018, 9, 1473–1480. DOI: 10.1039/c7sc04691j


675. Oxidative β-C–H sulfonylation of cyclic amines

R. J. Griffiths; W. C. Kong; S. A. Richards; G. A. Burley; M. C. Willis; E. P. A. Talbot. Chem. Sci. 2018, 9, 2295–2300. DOI: 10.1039/c7sc04900e


676. Enantiocontrol by assembled attractive interactions in copper-catalyzed asymmetric direct alkynylation of α-ketoesters with terminal alkynes: OH⋯O/sp3-CH⋯O two-point hydrogen bonding combined with dispersive attractions

Martin C. Schwarzer; Akane Fujioka; Takaoki Ishii; Hirohisa Ohmiya; Seiji Mori; Masaya Sawamura. Chem. Sci. 2018, 9, 3484–3493. DOI: 10.1039/c8sc00527c


677. Using stereoretention for the synthesis of E-macrocycles with ruthenium-based olefin metathesis catalysts

Tonia S. Ahmed; T. Patrick Montgomery; Robert H. Grubbs. Chem. Sci. 2018, 9, 3580–3583. DOI: 10.1039/c8sc00435h


678. A modular approach to prepare enantioenriched cyclobutanes: synthesis of (+)-rumphellaone A

Jordan C. Beck; Caitlin R. Lacker; Lauren M. Chapman; Sarah E. Reisman. Chem. Sci. null, null, null–null. DOI: 10.1039/c8sc05444d


679. Direct catalytic enantioselective amination of ketones for the formation of tri- and tetrasubstituted stereocenters

B. M. Trost; J. S. Tracy; T. Saget. Chem. Sci. 2018, 9, 2975–2980. DOI: 10.1039/c8sc00147b


680. Copper-catalyzed formylation of alkenyl C–H bonds using BrCHCl2 as a stoichiometric formylating reagent

Yan Bao; Gao-Yin Wang; Ya-Xuan Zhang; Kang-Jie Bian; Xi-Sheng Wang. Chem. Sci. 2018, 9, 2986–2990. DOI: 10.1039/c8sc00210j


681. Formation of quaternary centres by copper catalysed asymmetric conjugate addition to β-substituted cyclopentenones with the aid of a quantitative structure–selectivity relationship

Ruchuta Ardkhean; Mike Mortimore; Robert S. Paton; Stephen P. Fletcher. Chem. Sci. 2018, 9, 2628–2632. DOI: 10.1039/c7sc05304e


682. Combining traditional 2D and modern physical organic-derived descriptors to predict enhanced enantioselectivity for the key aza-Michael conjugate addition in the synthesis of Prevymis™ (letermovir)

Toni T. Metsänen; Katrina W. Lexa; Celine B. Santiago; Cheol K. Chung; Yingju Xu; Zhijian Liu; Guy R. Humphrey; Rebecca T. Ruck; Edward C. Sherer; Matthew S. Sigman. Chem. Sci. 2018, 9, 6922–6927. DOI: 10.1039/c8sc02089b


683. Bifunctional iminophosphorane catalysed enantioselective sulfa-Michael addition of alkyl thiols to alkenyl benzimidazoles

Michele Formica; Geoffroy Sorin; Alistair J. M. Farley; Jesús Díaz; Robert S. Paton; Darren J. Dixon. Chem. Sci. 2018, 9, 6969–6974. DOI: 10.1039/c8sc01804a


684. Catalyst-dependent selectivity in sulfonium ylide cycloisomerization reactions

Rik Oost; James D. Neuhaus; Antonio Misale; Ricardo Meyrelles; Luís F. Veiros; Nuno Maulide. Chem. Sci. 2018, 9, 7091–7095. DOI: 10.1039/c8sc02815j


685. A synergistic LUMO lowering strategy using Lewis acid catalysis in water to enable photoredox catalytic, functionalizing C–C cross-coupling of styrenes

Elisabeth Speckmeier; Patrick J. W. Fuchs; Kirsten Zeitler. Chem. Sci. 2018, 9, 7096–7103. DOI: 10.1039/c8sc02106f


686. Metal-free alkene oxy- and amino-perfluoroalkylations via carbocation formation by using perfluoro acid anhydrides: unique reactivity between styrenes and perfluoro diacyl peroxides

Elena Valverde; Shintaro Kawamura; Daisuke Sekine; Mikiko Sodeoka. Chem. Sci. 2018, 9, 7115–7121. DOI: 10.1039/c8sc02547a


687. meta-C–H arylation of fluoroarenes via traceless directing group relay strategy

Marc Font; Andrew R. A. Spencer; Igor Larrosa. Chem. Sci. 2018, 9, 7133–7137. DOI: 10.1039/c8sc02417k


688. Enantioselective fluorination of homoallylic alcohols enabled by the tuning of non-covalent interactions

Jaime A. S. Coelho; Akira Matsumoto; Manuel Orlandi; Margaret J. Hilton; Matthew S. Sigman; F. Dean Toste. Chem. Sci. 2018, 9, 7153–7158. DOI: 10.1039/c8sc02223b


689. Photocatalytic Barbier reaction – visible-light induced allylation and benzylation of aldehydes and ketones

Anna Lucia Berger; Karsten Donabauer; Burkhard König. Chem. Sci. 2018, 9, 7230–7235. DOI: 10.1039/c8sc02038h


690. Diastereoselective C–H carbonylative annulation of aliphatic amines: a rapid route to functionalized γ-lactams

Zhuang Mao Png; Jaime R. Cabrera-Pardo; Jorge Peiró Cadahía; Matthew J. Gaunt. Chem. Sci. 2018, 9, 7628–7633. DOI: 10.1039/c8sc02855a


691. Catalytic enantioselective radical coupling of activated ketones with N-aryl glycines

Yang Liu; Xiangyuan Liu; Jiangtao Li; Xiaowei Zhao; Baokun Qiao; Zhiyong Jiang. Chem. Sci. 2018, 9, 8094–8098. DOI: 10.1039/c8sc02948b


692. A quantitative reactivity scale for electrophilic fluorinating reagents

Neshat Rozatian; Ian W. Ashworth; Graham Sandford; David R. W. Hodgson. Chem. Sci. 2018, 9, 8692–8702. DOI: 10.1039/c8sc03596b


693. Post-transition state bifurcations induce dynamical detours in Pummerer-like reactions

Stephanie R. Hare; Ang Li; Dean J. Tantillo. Chem. Sci. 2018, 9, 8937–8945. DOI: 10.1039/c8sc02653j


694. Ir(III)-catalyzed ortho C–H alkylations of (hetero)aromatic aldehydes using alkyl boron reagents

Xiao-Yang Chen; Erik J. Sorensen. Chem. Sci. 2018, 9, 8951–8956. DOI: 10.1039/c8sc03606c


695. Metal-free, intermolecular carbopyridylation of alkenes via visible-light-induced reductive radical coupling

Dan Chen; Lei Xu; Tianyu Long; Shengqing Zhu; Jun Yang; Lingling Chu. Chem. Sci. 2018, 9, 9012–9017. DOI: 10.1039/c8sc03493a


696. Glass wool: a novel support for heterogeneous catalysis

Ayda Elhage; Bowen Wang; Nancy Marina; M. Luisa Marin; Menandro Cruz; Anabel E. Lanterna; Juan C. Scaiano. Chem. Sci. 2018, 9, 6844–6852. DOI: 10.1039/c8sc02115e


697. Rhodium-catalyzed ortho-heteroarylation of phenols: directing group-enabled switching of the electronic bias for heteroaromatic coupling partner

Yimin Wu; Wei Li; Linfeng Jiang; Luoqiang Zhang; Jingbo Lan; Jingsong You. Chem. Sci. 2018, 9, 6878–6882. DOI: 10.1039/c8sc02529k


698. Machine learning meets volcano plots: computational discovery of cross-coupling catalysts

Benjamin Meyer; Boodsarin Sawatlon; Stefan Heinen; O. Anatole von Lilienfeld; Clémence Corminboeuf. Chem. Sci. 2018, 9, 7069–7077. DOI: 10.1039/c8sc01949e


699. A mild light-induced cleavage of the S–O bond of aryl sulfonate esters enables efficient sulfonylation of vinylarenes

Maxim Ratushnyy; Monika Kamenova; Vladimir Gevorgyan. Chem. Sci. 2018, 9, 7193–7197. DOI: 10.1039/c8sc02769b


700. A β-diketiminate manganese catalyst for alkene hydrosilylation: substrate scope, silicone preparation, and mechanistic insight

Tufan K. Mukhopadhyay; Marco Flores; Thomas L. Groy; Ryan J. Trovitch. Chem. Sci. 2018, 9, 7673–7680. DOI: 10.1039/c8sc02768d


701. Selective C–H halogenation over hydroxylation by non-heme iron(IV)-oxo

Sujoy Rana; Jyoti Prasad Biswas; Asmita Sen; Martin Clémancey; Geneviève Blondin; Jean-Marc Latour; Gopalan Rajaraman; Debabrata Maiti. Chem. Sci. 2018, 9, 7843–7858. DOI: 10.1039/c8sc02053a


702. Multinuclear iron–phenyl species in reactions of simple iron salts with PhMgBr: identification of Fe4(μ-Ph)6(THF)4 as a key reactive species for cross-coupling catalysis

Stephanie H. Carpenter; Tessa M. Baker; Salvador B. Muñoz; William W. Brennessel; Michael L. Neidig. Chem. Sci. 2018, 9, 7931–7939. DOI: 10.1039/c8sc02915f


703. Chemoenzymatic synthesis of glycopeptides bearing rare N-glycan sequences with or without bisecting GlcNAc

Weizhun Yang; Sherif Ramadan; Jared Orwenyo; Tayeb Kakeshpour; Thomas Diaz; Yigitcan Eken; Miloslav Sanda; James E. Jackson; Angela K. Wilson; Xuefei Huang. Chem. Sci. 2018, 9, 8194–8206. DOI: 10.1039/c8sc02457j


704. Mechanistic study of styrene aziridination by iron(IV) nitrides

Douglas W. Crandell; Salvador B. Muñoz; Jeremy M. Smith; Mu-Hyun Baik. Chem. Sci. 2018, 9, 8542–8552. DOI: 10.1039/c8sc03677b


705. Hydrogen evolution from water catalyzed by cobalt-mimochrome VI*a, a synthetic mini-protein

Vincenzo Firpo; Jennifer M. Le; Vincenzo Pavone; Angela Lombardi; Kara L. Bren. Chem. Sci. 2018, 9, 8582–8589. DOI: 10.1039/c8sc01948g


706. Carbene-catalyzed enantioselective oxidative coupling of enals and di(hetero)arylmethanes

Qiao Chen; Tingshun Zhu; Pankaj Kumar Majhi; Chengli Mou; Huifang Chai; Jingjie Zhang; Shitian Zhuo; Yonggui Robin Chi. Chem. Sci. 2018, 9, 8711–8715. DOI: 10.1039/c8sc03480j


707. Two chiral catalysts in action: insights into cooperativity and stereoselectivity in proline and cinchona-thiourea dual organocatalysis

Bangaru Bhaskararao; Raghavan B. Sunoj. Chem. Sci. 2018, 9, 8738–8747. DOI: 10.1039/c8sc03078b


708. Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugation

David Montoir; Mehdi Amoura; Zine El Abidine Ababsa; T. M. Vishwanatha; Expédite Yen-Pon; Vincent Robert; Massimiliano Beltramo; Véronique Piller; Mouad Alami; Vincent Aucagne; Samir Messaoudi. Chem. Sci. 2018, 9, 8753–8759. DOI: 10.1039/c8sc02370k


709. Silver-mediated oxidative functionalization of alkylsilanes

Feng Wang; Peng Xu; Fei Cong; Pingping Tang. Chem. Sci. 2018, 9, 8836–8841. DOI: 10.1039/c8sc03730b


710. Copper-mediated 1,2-bis(trifluoromethylation) of arynes

Xinkan Yang; Gavin Chit Tsui. Chem. Sci. 2018, 9, 8871–8875. DOI: 10.1039/c8sc03754j


Chem. Sci./Chem. Commun.


711. Rhodium-catalyzed asymmetric hydroboration of γ,δ-unsaturated amide derivatives: δ-borylated amides

nullG. L. Hoang; S. Zhang; J. M. Takacs. Chem. Comm. 2018, 54, 4838–4841. DOI: 10.1039/c8cc01563e


712. The synergistic effect of self-assembly and visible-light induced the oxidative C–H acylation of N-heterocyclic aromatic compounds with aldehydes

nullLingling Zhang; Guoting Zhang; Yongli Li; Shengchun Wang; Aiwen Lei. Chem. Comm. 2018, 54, 5744–5747. DOI: 10.1039/c8cc02342e


713. Photoredox-promoted alkyl radical addition/semipinacol rearrangement sequences of alkenylcyclobutanols: rapid access to cyclic ketones

nullSheng Yao; Kai Zhang; Quan-Quan Zhou; Yu Zhao; De-Qing Shi; Wen-Jing Xiao. Chem. Comm. 2018, 54, 8096–8099. DOI: 10.1039/c8cc04503h


714. Electrocatalytic CO2 reduction by a cobalt bis(pyridylmonoimine) complex: effect of acid concentration on catalyst activity and stability

nullWeixuan Nie; Charles C. L. McCrory. Chem. Comm. 2018, 54, 1579–1582. DOI: 10.1039/c7cc08546j


715. Alkene functionalization for the stereospecific synthesis of substituted aziridines by visible-light photoredox catalysis

nullWan-Lei Yu; Jian-Qiang Chen; Yun-Long Wei; Zhu-Yin Wang; Peng-Fei Xu. Chem. Comm. 2018, 54, 1948–1951. DOI: 10.1039/c7cc09151f


716. Synthesis of polyfluoroarene-substituted benzofuran derivatives via cooperative Pd/Cu catalysis

nullYi Shen; Xin-Xing Wu; Si Chen; Yu Xia; Yong-Min Liang. Chem. Comm. 2018, 54, 2256–2259. DOI: 10.1039/c8cc00489g


717. Catalytic, metal-free sulfonylcyanation of alkenes via visible light organophotoredox catalysis

nullJianfeng Sun; Peng Li; Lei Guo; Fang Yu; Yu-Peng He; Lingling Chu. Chem. Comm. 2018, 54, 3162–3165. DOI: 10.1039/c8cc00547h


718. Carbon dioxide-based facile synthesis of cyclic carbamates from amino alcohols

nullTeemu Niemi; Israel Fernández; Bethany Steadman; Jere K. Mannisto; Timo Repo. Chem. Comm. 2018, 54, 3166–3169. DOI: 10.1039/c8cc00636a


719. Palladium-catalyzed site-selective arylation of aliphatic ketones enabled by a transient ligand

nullLei Pan; Ke Yang; Guigen Li; Haibo Ge. Chem. Comm. 2018, 54, 2759–2762. DOI: 10.1039/c8cc00980e


720. Photochemical activation of SF6 by N-heterocyclic carbenes to provide a deoxyfluorinating reagent

nullPooja Tomar; Thomas Braun; Erhard Kemnitz. Chem. Comm. 2018, 54, 9753–9756. DOI: 10.1039/c8cc05494k


721. Enantioselective acyl-transfer catalysis by fluoride ions

nullRyan Craig; Mili Litvajova; Sarah A. Cronin; Stephen J. Connon. Chem. Comm. 2018, 54, 10108–10111. DOI: 10.1039/c8cc05692g


722. Application of coumarin dyes for organic photoredox catalysis

nullAndrea Gualandi; Giacomo Rodeghiero; Emanuele Della Rocca; Francesco Bertoni; Marianna Marchini; Rossana Perciaccante; Thomas Paul Jansen; Paola Ceroni; Pier Giorgio Cozzi. Chem. Comm. 2018, 54, 10044–10047. DOI: 10.1039/c8cc04048f


723. Enantioselectively functionalised phenytoin derivatives by auxiliary-directed N to C aryl migration in lithiated α-amino nitriles

nullJosep Mas-Roselló; Mary Okoh; Jonathan Clayden. Chem. Comm. 2018, 54, 10985–10988. DOI: 10.1039/c8cc06833j


724. Fe-Catalyzed three-component carboazidation of alkenes with alkanes and trimethylsilyl azide

nullWei-Yu Li; Chuan-Shuo Wu; Zhou Wang; Yang Luo. Chem. Comm. 2018, 54, 11013–11016. DOI: 10.1039/c8cc05090b


725. Reinventing the De Mayo reaction: synthesis of 1,5-diketones or 1,5-ketoesters via visible light [2+2] cycloaddition of β-diketones or β-ketoesters with styrenes

nullRebeca Martinez-Haya; Leyre Marzo; Burkhard König. Chem. Comm. 2018, 54, 11602–11605. DOI: 10.1039/c8cc07044j


726. C–H functionalisation of aldehydes using light generated, non-stabilised diazo compounds in flow

nullPaul Dingwall; Andreas Greb; Lorène N. S. Crespin; Ricardo Labes; Biagia Musio; Jian-Siang Poh; Patrick Pasau; David C. Blakemore; Steven V. Ley. Chem. Comm. 2018, 54, 11685–11688. DOI: 10.1039/c8cc06202a


727. Catalytic asymmetric propargyl- and allylboration of hydrazonoesters: a metal-free approach to sterically encumbered chiral α-amino acid derivatives

nullSybrand J. T. Jonker; Colin Diner; Göran Schulz; Hiroaki Iwamoto; Lars Eriksson; Kálmán J. Szabó. Chem. Comm. 2018, 54, 12852–12855. DOI: 10.1039/c8cc07908k


728. An efficient method for retro-Claisen-type C–C bond cleavage of diketones with tropylium catalyst

nullM. A. Hussein; V. T. Huynh; R. Hommelsheim; R. M. Koenigs; T. V. Nguyen. Chem. Comm. 2018, 54, 12970–12973. DOI: 10.1039/c8cc07329e


729. Asymmetric synthesis of Rauhut–Currier-type esters via Mukaiyama–Michael reaction to acylphosphonates under bifunctional catalysis

nullVíctor Laina-Martín; Roberto del Río-Rodríguez; Sergio Díaz-Tendero; Jose A. Fernández-Salas; José Alemán. Chem. Comm. 2018, 54, 13941–13944. DOI: 10.1039/c8cc07561a


Adv. Syn. Cat.


730. Sequential Photoredox Catalysis for Cascade Aerobic Decarboxylative Povarov and Oxidative Dehydrogenation Reactions of N‐Aryl α‐Amino Acids

Tianju Shao; Yanli Yin; Richmond Lee; Xiaowei Zhao; Guobi Chai; Zhiyong Jiang. Adv. Syn. Cat. 2018, 360, 1754–1760. DOI: 10.1002/adsc.201800135


731. Chiral Ion‐Pair Organocatalyst‐Promoted Efficient Enantio‐selective Reduction of α‐Hydroxy Ketones

Yiliang Zhang; Li He; Lei Shi. Adv. Syn. Cat. 2018, 360, 1926–1931. DOI: 10.1002/adsc.201800053


732. Asymmetric Nazarov Cyclizations Catalyzed by Chiral‐at‐Metal Complexes

Thomas Mietke; Thomas Cruchter; Vladimir A. Larionov; Tabea Faber; Klaus Harms; Eric Meggers. Adv. Syn. Cat. 2018, 360, 2093–2100. DOI: 10.1002/adsc.201701546


733. PhIO/Et3N ⋅ 3HF‐Mediated Formation of Fluorinated 2H‐Azirines via Domino Fluorination/Azirination Reaction of Enamines

Yong Zhang; Xiaoyuan Zhao; Chen Zhuang; Senlin Wang; Daisy Zhang‐Negrerie; Yunfei Du. Adv. Syn. Cat. 2018, 360, 2107–2112. DOI: 10.1002/adsc.201800124


734. Chiral N,N′‐Dioxide/ScΙΙΙ Complex‐Catalyzed Asymmetric Ring‐Opening Reaction of Cyclopropyl Ketones with Indoles

Fenzhen Chang; Lili Lin; Yong Xia; Hang Zhang; Shunxi Dong; Xiaohua Liu; Xiaoming Feng. Adv. Syn. Cat. 2018, 360, 2608–2612. DOI: 10.1002/adsc.201800312


735. 2‐Azaallyl Anions as Light‐Tunable Super‐Electron‐Donors: Coupling with Aryl Fluorides, Chlorides, and Bromides

Qianmei Wang; Michal Poznik; Minyan Li; Patrick J. Walsh; Jason J. Chruma. Adv. Syn. Cat. 2018, 360, 2854–2868. DOI: 10.1002/adsc.201800396


736. Palladium‐Catalyzed Ring‐Opening of 2‐Alkylidenecyclobutanols: Stereoselective Synthesis of γ,δ‐Unsaturated Ketones by C−C Bond Cleavage

Ling Chen; Feng‐Na Sun; Yu‐Li Sun; Zheng Xu; Zhan‐Jiang Zheng; Yu‐Ming Cui; Jian Cao; Li‐Wen Xu. Adv. Syn. Cat. 2018, 360, 411–415. DOI: 10.1002/adsc.201701078


737. Iridium‐Catalyzed Dynamic Kinetic Stereoselective Allylic Etherification of Achmatowicz Rearrangement Products

Zhongpeng Zhu; Hao‐Yuan Wang; Christopher Simmons; Po‐Sen Tseng; Xiang Qiu; Yu Zhang; Xiyan Duan; Jing‐Kui Yang; Weiping Tang. Adv. Syn. Cat. 2018, 360, 595–599. DOI: 10.1002/adsc.201700950


738. Merging Brønsted Acid and Hydrogen‐Bonding Catalysis: Metal‐Free Dearomatization of Phenols via ipso‐Friedel‐Crafts Alkylation to Produce Functionalized Spirolactams

Shingo Harada; Irene Mei‐Yi Kwok; Hiroki Nakayama; Ayaka Kanda; Tetsuhiro Nemoto. Adv. Syn. Cat. 2018, 360, 801–807. DOI: 10.1002/adsc.201701287


Proc. Nat. Acad. Sci.


739. Kinetically guided radical-based synthesis of C(sp3)−C(sp3) linkages on DNA

[no graphical abstract]

Jie Wang; Helena Lundberg; Shota Asai; Pedro Martín-Acosta; Jason S. Chen; Stephen Brown; William Farrell; Russell G. Dushin; Christopher J. O’Donnell; Anokha S. Ratnayake; Paul Richardson; Zhiqing Liu; Tian Qin; Donna G. Blackmond; Phil S. Baran. Proc. Nat. Acad. Sci. 2018, 115, 6404–6410. DOI: 10.1073/pnas.1806900115


740. Control of chemoselectivity in asymmetric tandem reactions: Direct synthesis of chiral amines bearing nonadjacent stereocenters

[no graphical abstract]

Zhe Li; Bin Hu; Yongwei Wu; Chao Fei; Li Deng. Proc. Nat. Acad. Sci. 2018, 115, 1730–1735. DOI: 10.1073/pnas.1718474115


741. Ligand “noninnocence” in coordination complexes vs. kinetic, mechanistic, and selectivity issues in electrochemical catalysis

[no graphical abstract]

Cyrille Costentin; Jean-Michel Savéant; Cédric Tard. Proc. Nat. Acad. Sci. 2018, 115, 9104–9109. DOI: 10.1073/pnas.1810255115


742. Critical computational analysis illuminates the reductive-elimination mechanism that activates nitrogenase for N2 reduction

[no graphical abstract]

Simone Raugei; Lance C. Seefeldt; Brian M. Hoffman. Proc. Nat. Acad. Sci. 2018, 115, 10521–10530. DOI: 10.1073/pnas.1810211115


743. Structural analysis of transient reaction intermediate in formic acid dehydrogenation catalysis using two-dimensional IR spectroscopy

[no graphical abstract]

Yufan Zhang; Xin Chen; Bin Zheng; Xunmin Guo; Yupeng Pan; Hailong Chen; Huaifeng Li; Shixiong Min; Chao Guan; Kuo-Wei Huang; Junrong Zheng. Proc. Nat. Acad. Sci. 2018, 115, 12395–12400. DOI: 10.1073/pnas.1809342115


744. Directing the reactivity of metal hydrides for selective CO2 reduction

[no graphical abstract]

Bianca M. Ceballos; Jenny Y. Yang. Proc. Nat. Acad. Sci. 2018, 115, 12686–12691. DOI: 10.1073/pnas.1811396115


ACS Cent. Sci.


745. Catalyst-Controlled Stereodivergent Synthesis of Atropisomeric Multiaxis Systems

Dominik Lotter; Alessandro Castrogiovanni; Markus Neuburger; Christof Sparr. ACS Cent. Sci. 2018, 4, 656–660. DOI: 10.1021/acscentsci.8b00204


746. Delineating Physical Organic Parameters in Site-Selective C–H Functionalization of Indoles

Youyoung Kim; Yoonsu Park; Sukbok Chang. ACS Cent. Sci. 2018, 4, 768–775. DOI: 10.1021/acscentsci.8b00264


747. Rationalization of Asymmetric Amplification via Autocatalysis Triggered by Isotopically Chiral Molecules

Neil A. Hawbaker; Donna G. Blackmond. ACS Cent. Sci. 2018, 4, 776–780. DOI: 10.1021/acscentsci.8b00297


748. Carbonate-Promoted Hydrogenation of Carbon Dioxide to Multicarbon Carboxylates

Aanindeeta Banerjee; Matthew W. Kanan. ACS Cent. Sci. 2018, 4, 606–613. DOI: 10.1021/acscentsci.8b00108


749. Diverse Engineered Heme Proteins Enable Stereodivergent Cyclopropanation of Unactivated Alkenes

Anders M. Knight; S. B. Jennifer Kan; Russell D. Lewis; Oliver F. Brandenberg; Kai Chen; Frances H. Arnold. ACS Cent. Sci. 2018, 4, 372–377. DOI: 10.1021/acscentsci.7b00548


750. Reduction and Condensation of Aldehydes by the Isolated Cofactor of Nitrogenase

Chi Chung Lee; Yilin Hu; Markus W. Ribbe. ACS Cent. Sci. 2018, 4, 1430–1435. DOI: 10.1021/acscentsci.8b00553


751. The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination

Christopher G. Jones; Michael W. Martynowycz; Johan Hattne; Tyler J. Fulton; Brian M. Stoltz; Jose A. Rodriguez; Hosea M. Nelson; Tamir Gonen. ACS Cent. Sci. 2018, 4, 1587–1592. DOI: 10.1021/acscentsci.8b00760


752. Using Machine Learning To Predict Suitable Conditions for Organic Reactions

Hanyu Gao; Thomas J. Struble; Connor W. Coley; Yuran Wang; William H. Green; Klavs F. Jensen. ACS Cent. Sci. 2018, 4, 1465–1476. DOI: 10.1021/acscentsci.8b00357


753. Acyl Glycosides through Stereospecific Glycosyl Cross-Coupling: Rapid Access to C(sp3)-Linked Glycomimetics

Feng Zhu; Jacob Rodriguez; Sloane O’Neill; Maciej A. Walczak. ACS Cent. Sci. 2018, 4, 1652–1662. DOI: 10.1021/acscentsci.8b00628